LAB/IN VITRO RESEARCH e-ISSN 1643-3750 © Med Sci Monit, 2016; 22: 2195-2201 DOI: 10.12659/MSM.899377
Plasma miRNA-506 as a Prognostic Biomarker for Esophageal Squamous Cell Carcinoma
Received: 2016.05.02 Accepted: 2016.06.01 Published: 2016.06.27
Authors’ Contribution: Study Design A Data Collection B Analysis C Statistical Data Interpretation D Manuscript Preparation E Literature Search F Funds Collection G
BCDE 1 BCF 1 ACD 2 AE 2
Corresponding Author: Source of support:
Background:
Material/Methods:
Results:
Conclusions:
MeSH Keywords:
Full-text PDF:
Shu-Ping Li Hong-Xin Su Da Zhao Quan-Lin Guan
1 Department of Radiation Oncology, The First Hospital of Lanzhou University, Lanzhou, Gansu, P.R. China 2 Department of Oncology, The First Hospital of Lanzhou University, Lanzhou, Gansu, P.R. China
Quan-Lin Guan, e-mail: [email protected] Departmental sources
MicroRNAs (miRNAs) are responsible for regulating proliferation, differentiation, apoptosis, invasion, and metastasis in tumor cells. miRNA-506 is abnormally expressed in multiple tumors, indicating that it might be oncogenic or tumor-suppressive. However, little is known about the association between miRNA-506 expression and esophageal squamous cell carcinoma (ESCC). We examined the expression of miRNA-506 in the plasma of ESCC patients using quantitative real-time polymerase chain reaction (qRT-PCR) to determine the association between miRNA-506 expression and clinicopathological features of ESCC. ROC curves were produced for ESCC diagnosis by plasma miRNA-506 and the area under curve was calculated to explore its diagnostic value. Average miRNA-506 expression levels were remarkably higher in the plasma of ESCC patients than in healthy volunteers (P
Plasma miRNA-506 as a Prognostic Biomarker for Esophageal Squamous Cell Carcinoma
Received: 2016.05.02 Accepted: 2016.06.01 Published: 2016.06.27
Authors’ Contribution: Study Design A Data Collection B Analysis C Statistical Data Interpretation D Manuscript Preparation E Literature Search F Funds Collection G
BCDE 1 BCF 1 ACD 2 AE 2
Corresponding Author: Source of support:
Background:
Material/Methods:
Results:
Conclusions:
MeSH Keywords:
Full-text PDF:
Shu-Ping Li Hong-Xin Su Da Zhao Quan-Lin Guan
1 Department of Radiation Oncology, The First Hospital of Lanzhou University, Lanzhou, Gansu, P.R. China 2 Department of Oncology, The First Hospital of Lanzhou University, Lanzhou, Gansu, P.R. China
Quan-Lin Guan, e-mail: [email protected] Departmental sources
MicroRNAs (miRNAs) are responsible for regulating proliferation, differentiation, apoptosis, invasion, and metastasis in tumor cells. miRNA-506 is abnormally expressed in multiple tumors, indicating that it might be oncogenic or tumor-suppressive. However, little is known about the association between miRNA-506 expression and esophageal squamous cell carcinoma (ESCC). We examined the expression of miRNA-506 in the plasma of ESCC patients using quantitative real-time polymerase chain reaction (qRT-PCR) to determine the association between miRNA-506 expression and clinicopathological features of ESCC. ROC curves were produced for ESCC diagnosis by plasma miRNA-506 and the area under curve was calculated to explore its diagnostic value. Average miRNA-506 expression levels were remarkably higher in the plasma of ESCC patients than in healthy volunteers (P
