Plasma Homocysteine and Arterial Stiffness: Risk Factors or Risk Markers for Cardiovascular Diseases? Ferreira, DSc Arthur de Sa s-graduacßa ~o em Cie ^ncias da Reabilitacß a ~o, Centro Universita rio Augusto Motta/UNISUAM, Rio de Janeiro, RJ, Brazil From the Programa de Po
Wang and colleagues1 investigated plasma total homocysteine as a predictor of arterial stiffness in a community-based cohort of 1447 patients with cardiovascular diseases (CVDs) during 4.8 years of follow-up. Carotidfemoral pulse wave velocity (cf-PWV) and carotid-radial pulse wave velocity (cr-PWV) were noninvasively measured for assessment of central and peripheral arterial stiffness, respectively. Their analyses revealed a positive, weak association of baseline homocysteine levels with follow-up cf-PWV (Pearson’s r=0.274, P