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doi: 10.1111/ppe.12184

211

Placental Abruption and Subsequent Risk of Pre-eclampsia: A Population-Based Case–Control Study Samantha E. Parker,a Martha M. Werler,a Mika Gissler,b,d Minna Tikkanen,c Cande V. Ananthe,f a

Department of Epidemiology, Boston University School of Public Health, Boston, MA b

National Institute of Health and Welfare (THL) Helsinki, Finland

c

Department of Obstetrics and Gynecology, Helsinki University Central Hospital, University of Helsinki, Helsinki, Finland d

NHV Nordic School of Public Health, Gothenburg, Sweden

e

Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY f

Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY

Abstract Background: Pre-eclampsia and placental abruption may share a common pathophysiologic mechanism, namely, uteroplacental ischaemia. The aim of this study was to investigate the association between placental abruption and risk of pre-eclampsia in a subsequent pregnancy, and to determine whether the association differs by the gestational age at the time of abruption. Methods: A nested case–control study among multiparous women in the Medical Birth Register of Finland from 1996–2010 was conducted. Cases of pre-eclampsia (n = 6487) and frequency matched controls (n = 25 948) were linked to the Hospital Discharge Registry to ascertain data on prior abruption. Abruption was categorised as preterm (