Clinical Endocrinology (1991) 34, 371-376
Physiological growth hormone secretion in adult growth hormone deficiency: comparison with normal controls Helen M. Whltehead', Brenda Alkent, Stuart LewlsS, Brlan Sherldans and David R. Hadden' 'Sir George E. Clark Metabolic Unit and §Endocrine Laboratory, Royal Victoria Hospital; tEEG Department, Meter lnfirmorum Hospital. and $Department of Mental Health, The Queen's University of Belfast, Northern Ireland. UK (Received 30 August 7990; returned for revision 22 October 7990; finally revised 3 December 7990; accepted 3 January 7997)
Summary A comparison was made between the pulsatlle pattern of growth hormone secretlon In 14 growth hormone deficient adults (serum growth hormone less than 7 mull following insulin-stlmulated hypoglycaemia) and 14 age and sex matched controls. The 24-h secretory proflle was generated by 2-hourly sampling from O800 to 2200 h, and 30-mln sampling from 2200 to 0600 h. Plasma GH In each sample was measured uslng a double antlbody radlolmmunoassay. The proflles were analysed utlng a computer program (Pulsar). Sleep-electroencephalography was recorded In all subjects. The total amount of GH secreted In a 24-h period (area under the curve over basellne) was slgnlflcantly less In the growth hormone deflclent group ( P < 0.002). The pulse frequency, amplitude, height and percentage GH secreted In peaks were also slgnlflcantly less In the growth hormone deficlent group (P
Physiological growth hormone secretion in adult growth hormone deficiency: comparison with normal controls Helen M. Whltehead', Brenda Alkent, Stuart LewlsS, Brlan Sherldans and David R. Hadden' 'Sir George E. Clark Metabolic Unit and §Endocrine Laboratory, Royal Victoria Hospital; tEEG Department, Meter lnfirmorum Hospital. and $Department of Mental Health, The Queen's University of Belfast, Northern Ireland. UK (Received 30 August 7990; returned for revision 22 October 7990; finally revised 3 December 7990; accepted 3 January 7997)
Summary A comparison was made between the pulsatlle pattern of growth hormone secretlon In 14 growth hormone deficient adults (serum growth hormone less than 7 mull following insulin-stlmulated hypoglycaemia) and 14 age and sex matched controls. The 24-h secretory proflle was generated by 2-hourly sampling from O800 to 2200 h, and 30-mln sampling from 2200 to 0600 h. Plasma GH In each sample was measured uslng a double antlbody radlolmmunoassay. The proflles were analysed utlng a computer program (Pulsar). Sleep-electroencephalography was recorded In all subjects. The total amount of GH secreted In a 24-h period (area under the curve over basellne) was slgnlflcantly less In the growth hormone deflclent group ( P < 0.002). The pulse frequency, amplitude, height and percentage GH secreted In peaks were also slgnlflcantly less In the growth hormone deficlent group (P
