Physiologic Underpinnings for C l i n i c a l P ro b l e m s in Mo d e r a t e l y P re t e r m an d L a t e P re t e r m In f a n t s Rakesh Sahni,


Richard A. Polin,


KEYWORDS  Thermoregulation  Respiratory morbidities  Immunologic immaturity  Glucose homeostasis  Gastrointestinal immaturity  Hepatic immaturity  Brain dysmaturity KEY POINTS  Preterm birth, even a few weeks before term, is associated with a high prevalence of clinical problems.  Issues arise from functional immaturities of a wide variety of organ systems, acquired problems, and problems associated with inadequate monitoring and/or follow-up plans.  Different organ systems mature at rates and trajectories that are specific to their functions, whereas maturation rates vary amongst infants. A better understanding of these principles can help guide optimal treatment strategies.


In the United States approximately 1 in 8 infants is born prematurely (

Physiologic underpinnings for clinical problems in moderately preterm and late preterm infants.

This article highlights some of the important developmental characteristics that underpin common problems seen in moderate and late preterm infants. P...
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