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received: 04 September 2015 accepted: 06 November 2015 Published: 08 December 2015

Perinatal Oxidative Stress May Affect Fetal Ghrelin Levels in Humans Zhong-Cheng Luo1,2, Jean-François Bilodeau3, Anne Monique Nuyt4, William D. Fraser8, Pierre Julien6,7, Francois Audibert2, Lin Xiao2, Carole Garofalo5 & Emile Levy5 In vitro cell model studies have shown that oxidative stress may affect beta-cell function. It is unknown whether oxidative stress may affect metabolic health in human fetuses/newborns. In a singleton pregnancy cohort (n = 248), we studied maternal (24–28 weeks gestation) and cord plasma biomarkers of oxidative stress [malondialdehyde (MDA), F2-isoprostanes] in relation to fetal metabolic health biomarkers including cord plasma glucose-to-insulin ratio (an indicator of insulin sensitivity), proinsulinto-insulin ratio (an indicator of beta-cell function), insulin, IGF-I, IGF-II, leptin, adiponectin and ghrelin concentrations. Strong positive correlations were observed between maternal and cord plasma biomarkers of oxidative stress (r = 0.33 for MDA, r = 0.74 for total F2-isoprostanes, all p 

Perinatal Oxidative Stress May Affect Fetal Ghrelin Levels in Humans.

In vitro cell model studies have shown that oxidative stress may affect beta-cell function. It is unknown whether oxidative stress may affect metaboli...
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