RESEARCH ARTICLE
Pentoxifylline for Anemia in Chronic Kidney Disease: A Systematic Review and MetaAnalysis Davide Bolignano1*, Graziella D’Arrigo1, Anna Pisano1, Giuseppe Coppolino2 1 CNR- Institute of Clinical Physiology, Reggio Calabria, Italy, 2 Nephrology and Dialysis Unit, University Hospital, Catanzaro, Italy * [email protected]
Abstract Background Pentoxifylline (PTX) is a promising therapeutic approach for reducing inflammation and improving anemia associated to various systemic disorders. However, whether this agent may be helpful for anemia management also in CKD patients is still object of debate.
Study Design OPEN ACCESS Citation: Bolignano D, D’Arrigo G, Pisano A, Coppolino G (2015) Pentoxifylline for Anemia in Chronic Kidney Disease: A Systematic Review and Meta-Analysis. PLoS ONE 10(8): e0134104. doi:10.1371/journal.pone.0134104 Editor: Emmanuel A Burdmann, University of Sao Paulo Medical School, BRAZIL Received: May 22, 2015 Accepted: July 6, 2015 Published: August 3, 2015 Copyright: © 2015 Bolignano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Systematic review and meta-analysis.
Population Adults with CKD (any KDOQI stage, including ESKD patients on regular dialysis) and anemia (Hb
Pentoxifylline for Anemia in Chronic Kidney Disease: A Systematic Review and MetaAnalysis Davide Bolignano1*, Graziella D’Arrigo1, Anna Pisano1, Giuseppe Coppolino2 1 CNR- Institute of Clinical Physiology, Reggio Calabria, Italy, 2 Nephrology and Dialysis Unit, University Hospital, Catanzaro, Italy * [email protected]
Abstract Background Pentoxifylline (PTX) is a promising therapeutic approach for reducing inflammation and improving anemia associated to various systemic disorders. However, whether this agent may be helpful for anemia management also in CKD patients is still object of debate.
Study Design OPEN ACCESS Citation: Bolignano D, D’Arrigo G, Pisano A, Coppolino G (2015) Pentoxifylline for Anemia in Chronic Kidney Disease: A Systematic Review and Meta-Analysis. PLoS ONE 10(8): e0134104. doi:10.1371/journal.pone.0134104 Editor: Emmanuel A Burdmann, University of Sao Paulo Medical School, BRAZIL Received: May 22, 2015 Accepted: July 6, 2015 Published: August 3, 2015 Copyright: © 2015 Bolignano et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Systematic review and meta-analysis.
Population Adults with CKD (any KDOQI stage, including ESKD patients on regular dialysis) and anemia (Hb
