Circulation Research An Official Journal of the American Heart Asnoeiation Circulation Research provides a medium for bringing together basic research on the cardiovascular system from various disciplines including biology, biochemistry, biophysics, morphology, pathology, physiology, and pharmacology. The Journal also will accept for publication manuscripts on clinical research that contribute to an understanding of fundamental problems. Editor BRIAN F. HOFFMAN

Associate Editor MICHAEL R. ROSEN

Editorial Office: Department of Pharmacology, College of Physicians and Surgeons, 630 West 168th Street, New York, New York 10032

EDITORIAL BOARD

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ANTONIO M. GOTTO, JR. FRANCIS J. HADDY LLOYD L. HEFNER PHILIP D. HENRY MICHAEL HEYMANN PERRY M. HOG AN ROBERT B. JENNINGS ARNOLD M. KATZ PHILIP A. KHAIRALLAH MATTHEW N. LEVY THOMAS C. LLOYD, JR. JEAN M. MARSHALL PAUL MARTIN DEAN T. MASON JOHN C. MCGIFF NEIL C. MORAN EUGENE MORKIN RICHARD A. MURPHY JAMES R. NEELY YALE NEMERSON MARK NOBLE RAY A. OLSSON WILLIAM W. PARMLEY

ROBERT S. ALEXANDER ROGER C. BARR ARTHUR L. BASSETT DEREK BERGEL JOHN A. BEVAN EDWIN L. BIERMAN COLIN M. BLOOR BARRY M. BRENNER MICHAEL J. BRODY F. MERLIN BUMPUS EDWARD CARMELIET ROBERT B. CASE SHU CHIEN WILLIAM E. CONNOR JAMES W. COVELL DAVID E. DONALD AUSTIN E. DOYLE GEORGE I. DRUMMOND BRIAN R. DULING DIRK DURRER ALEXANDRE FABIATO RAY W. FULLER W. RAY GIBBONS

ROBERT

David Blankenhorn Los Angeles, Calif. Neal Bricker Miami, Fla. C. Richard Conti Gainesville, Fla. John Evers Chicago, III.

SOLBERT PERMUTT BERTRAM PITT OSCAR W. PORTMAN EUGENE M. RENKIN HARALD REUTER KIICHI SAGAWA JAMES SCHEUER EVELINE E. SCHNEEBERGER JOHN T. SHEPHERD LEONARD T. SKEGGS BURTON E. SOBEL MADISON S. SPACH S. P. SUTERA HAROLD J. SWAN MERRILL TARR AUBREY E. TAYLOR MARIO VASSALLE JOHN B. WEST RICHARD P. WHITE ERICH E. WINDHAGER SAUL WINEGRAD ANDREW L. WIT

M. BERNE; JULIUS H. COMROE, JR., Consulting Editors SIVIA BRODSKY, Assistant Editor

Publications Committee, American Heart Association Donald Harrison, Chairman Stanford, Calif. Eugene A. Stead, Jr. Joan Fitzmaurice Herbert J. Levine Durham, N.C. West Roxbury, Mass. Boston, Mass. Arthur Waltz Edgar Haber Fletcher McDowell San Francisco, Calif. Boston, Mass. White Plains, N.Y. Paul Yu Milton C. Paige, Jr. Brian F. Hoffman Rochester, N. Y. Boston, Mass. New York, N.Y. Thomas N. James Abraham Rudolph Birmingham, Ala. San Francisco, Calif.

Published monthly at the Publications Office* American Heart Association. 7320 Greenville Avenue, Dallas. Texas 75231. Second class postage paid at Dallas, Texas, and additional mailing offices. Copyright © 1977 by the American Heart Association, Inc.. 7320 Greenville Avenue, Dallas, Texas 75231