Original Article Journal JCBN the 1880-5086 0912-0009 Kyoto, Original 10.3164/jcbn.15-138 jcbn15-138 Society Japan ofArticle Clinical for FreeBiochemistry Radical Research and Nutrition Japan Painreducing anesthesia prevents oxidative stress in human term placenta Yoko Tsuzuki,1,2,3 Yoriko Yamashita,1,3,* Yuka Hattori,1,4 Guang Hua Li,1 Shinya Akatsuka,1 Tomomi Kotani,4 Fumitaka Kikkawa,4 Aya NaikiIto,3 Satoru Takahashi,3 Kimitoshi Nishiwaki2 and Shinya Toyokuni1,* 1

Department of Pathology and Biological Responses, 2Department of Anesthesiology and Resuscitation and 4Department of Obstetrics and Gynecology, Nagoya University Graduate School of Medicine, 65 Tsurumaicho, Showaku, Nagoya 4668550, Japan 3 Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuhocho, Mizuhoku, Nagoya 4678601, Japan

(Received 31 October, 2015; Accepted 12 November, 2015; Published online 17 February, 2016) 3

Anesthesia isopen for the reduction ofthe maternal pain vided Creative stricted Copyright This 2016 the isuse, original an Commons distribution, ©sometimes 2016 work access JCBN Attribution isused article and properly reproduction distributed License, cited. under which in any permits medium, terms of unreprothe in normal human term labor, but whether the drugs affect oxidative stress remains unclear. The placenta serves as an inter face between the maternal and fetal vasculature. In this study, we immunohistochemically analyzed two markers for oxidative stress, namely 8hydroxy2'deoxyguanosine (8OHdG) and 4 hydroxy2nonenal–modified proteins (HNE), using placentas from 21 cases of normal tansvaginal delivery (V group), 20 Caesarean sections (C group), and 17 normal transvaginal deliveries with epidural anesthesia (E group). 8OHdG staining in the nuclei of trophoblasts lining the chorionic villi was significantly stronger in the V group either compared with the C or E group (p

Pain-reducing anesthesia prevents oxidative stress in human term placenta.

Anesthesia is sometimes used for the reduction of maternal pain in normal human term labor, but whether the drugs affect oxidative stress remains uncl...
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