Poster Presentations / Pregnancy Hypertension: An International Journal of Women’s Cardiovascular Health 1 (2011) 273–299
tational week 14.9 was performed. Pulsatility Index (PI) was measured and mean calculated. To correlate for gestational age PI was expressed as multiples of the median (MoM). Results: The levels of HRG did not significantly differ between controls and women developing preeclampsia in total but there was a significant difference between controls and women developing preterm preeclampsia (82.7 lg/mL compared to 45.0 lg/mL, p = 0.001). The median PI MoM differed significantly for all cases compared to controls (1.1 compared to 1.0, p < 0.05) and for preterm preeclampsia compared to controls (1.6 compared to 1.0, p < 0.001). A receiver–operator characteristic curve, regarding a combination of HRG and PI to test arbitrarily chosen cut-off values for prediction of preterm preeclampsia, revealed a sensitivity of 91% and a specificity of 62%. Conclusion: The combination of HRG and uterine artery Doppler might be used as a possible predictor of preterm preeclampsia in early pregnancy. doi:10.1016/j.preghy.2011.08.081
P22. Role of uterine artery doppler in pregnant women with chronic hypertension B. Moita, E. Baptista, C. Marques, T. Bombas, N. Bento, M.S.J. Pais, P. Moura (Obstetrics Department of Coimbra University Hospitals, Portugal) Introduction/objectives: Abnormal placental vascular development is the basis of common obstetric disorders such as preeclampsia (PE). Uterine artery Doppler has been used as a screening test of placental vasculopathy. The objective of this study was to examine the value of uterine artery Doppler investigation in predicting PE and perinatal outcome of patients with chronic hypertension. Materials/methods: A retrospective study from January 2005 to December 2009 was realized. Uterine artery velocimetry was investigated at second trimester gestation in 107 chronic hypertensive pregnant women and the presence of bilateral diastolic notch was recorded. We compared two groups: group I-without bilateral notch; group II-with bilateral notch. Results: Twenty four percent of women had uterine artery Doppler with bilateral notch (group II). Primiparity was found in: I-36%; II-58% (p < 0,05) and overweight or obesity in: I-63% vs II-58% (p = ns). The development of superimposed PE rate was higher in group II (I-11% vs II35%) (p < 0,005), as well as intrauterine growth restriction (I-10% vs II-38%) (p < 0,05) and preterm delivery (I-11% vs II-35%) (p < 0,001). Caesarean section was performed in: I44% vs II-85% (p < 0,001) and the mean gestacional age at delivery time was: I -37 weeks vs II-36 weeks (p = ns). Regarding perinatal outcome, in group II birthweight mean was lower (I-3118gr vs II-2225gr) (p < 0,001) and a higher rate of admission in neonatal care unit was found (I-9.9% vs II-50%)(p < 0.001), although Apgar scores were similar between the groups. Conclusion: Doppler analysis of uterine arteries is able to select chronic hypertensive pregnant women at risk of superimposed preeclampsia and poor perinatal outcome.
283
The presenting investigator is eligible for the young investigator award (
tational week 14.9 was performed. Pulsatility Index (PI) was measured and mean calculated. To correlate for gestational age PI was expressed as multiples of the median (MoM). Results: The levels of HRG did not significantly differ between controls and women developing preeclampsia in total but there was a significant difference between controls and women developing preterm preeclampsia (82.7 lg/mL compared to 45.0 lg/mL, p = 0.001). The median PI MoM differed significantly for all cases compared to controls (1.1 compared to 1.0, p < 0.05) and for preterm preeclampsia compared to controls (1.6 compared to 1.0, p < 0.001). A receiver–operator characteristic curve, regarding a combination of HRG and PI to test arbitrarily chosen cut-off values for prediction of preterm preeclampsia, revealed a sensitivity of 91% and a specificity of 62%. Conclusion: The combination of HRG and uterine artery Doppler might be used as a possible predictor of preterm preeclampsia in early pregnancy. doi:10.1016/j.preghy.2011.08.081
P22. Role of uterine artery doppler in pregnant women with chronic hypertension B. Moita, E. Baptista, C. Marques, T. Bombas, N. Bento, M.S.J. Pais, P. Moura (Obstetrics Department of Coimbra University Hospitals, Portugal) Introduction/objectives: Abnormal placental vascular development is the basis of common obstetric disorders such as preeclampsia (PE). Uterine artery Doppler has been used as a screening test of placental vasculopathy. The objective of this study was to examine the value of uterine artery Doppler investigation in predicting PE and perinatal outcome of patients with chronic hypertension. Materials/methods: A retrospective study from January 2005 to December 2009 was realized. Uterine artery velocimetry was investigated at second trimester gestation in 107 chronic hypertensive pregnant women and the presence of bilateral diastolic notch was recorded. We compared two groups: group I-without bilateral notch; group II-with bilateral notch. Results: Twenty four percent of women had uterine artery Doppler with bilateral notch (group II). Primiparity was found in: I-36%; II-58% (p < 0,05) and overweight or obesity in: I-63% vs II-58% (p = ns). The development of superimposed PE rate was higher in group II (I-11% vs II35%) (p < 0,005), as well as intrauterine growth restriction (I-10% vs II-38%) (p < 0,05) and preterm delivery (I-11% vs II-35%) (p < 0,001). Caesarean section was performed in: I44% vs II-85% (p < 0,001) and the mean gestacional age at delivery time was: I -37 weeks vs II-36 weeks (p = ns). Regarding perinatal outcome, in group II birthweight mean was lower (I-3118gr vs II-2225gr) (p < 0,001) and a higher rate of admission in neonatal care unit was found (I-9.9% vs II-50%)(p < 0.001), although Apgar scores were similar between the groups. Conclusion: Doppler analysis of uterine arteries is able to select chronic hypertensive pregnant women at risk of superimposed preeclampsia and poor perinatal outcome.
283
The presenting investigator is eligible for the young investigator award (
