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Am J Nephrol. Author manuscript; available in PMC 2015 October 15. Published in final edited form as: Am J Nephrol. 2014 ; 40(3): 280–287. doi:10.1159/000366453.
Outcomes of Infected Cardiovascular Implantable Devices in Dialysis Patients Oluwaseun Opelami, MD1, Ankit Sakhuja, MD2, Xiaobo Liu, MS3, W. H. Wilson Tang, MD4,5, Jesse D. Schold, PhD3,5, and Sankar D. Navaneethan, MD, MPH1,5 1Department
of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH
Author Manuscript
2Division
of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI
3Department
of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH
4Department
of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH
5Cleveland
Clinic Lerner College of Medicine of CWRU, Cleveland Clinic, Cleveland, OH
Abstract
Author Manuscript
Background/Aims—Dialysis patients are at higher risk for cardiovascular implantable electronic device (CIED) infection related hospitalizations. We compared the outcomes and cost for dialysis and non-dialysis patients hospitalized with CIED infections. Methods—We conducted a retrospective analysis of the Nationwide Inpatient Sample (NIS) discharge records from 2005 to 2010. Patients with CIED infections were identified using ICD-9 codes for device-related infections or device procedure along with bacteremia, endocarditis or systemic infection. Dialysis patients were identified using ICD-9 codes. Multivariable logistic and linear regressions were performed to examine in-hospital mortality, length of stay and cost. Results—Of the 87,798 estimated hospitalizations with CIED-infections, 6,665 (7.6 %) were dialysis patients. CIED-infection related hospitalization has increased over time among dialysis patients. In-hospital mortality was higher among dialysis patients (13.6% vs. 5.9%, p < 0.001). In the multivariable model, dialysis patients had higher odds of in-hospital mortality (odds ratio 1.98; 95% CI: 1.6, 2.4) compared to the non-dialysis group. Dialysis patients had longer median length of stay (12 days vs. 7 days, p
Am J Nephrol. Author manuscript; available in PMC 2015 October 15. Published in final edited form as: Am J Nephrol. 2014 ; 40(3): 280–287. doi:10.1159/000366453.
Outcomes of Infected Cardiovascular Implantable Devices in Dialysis Patients Oluwaseun Opelami, MD1, Ankit Sakhuja, MD2, Xiaobo Liu, MS3, W. H. Wilson Tang, MD4,5, Jesse D. Schold, PhD3,5, and Sankar D. Navaneethan, MD, MPH1,5 1Department
of Nephrology and Hypertension, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH
Author Manuscript
2Division
of Nephrology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI
3Department
of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH
4Department
of Cardiovascular Medicine, Heart and Vascular Institute, Cleveland Clinic, Cleveland, OH
5Cleveland
Clinic Lerner College of Medicine of CWRU, Cleveland Clinic, Cleveland, OH
Abstract
Author Manuscript
Background/Aims—Dialysis patients are at higher risk for cardiovascular implantable electronic device (CIED) infection related hospitalizations. We compared the outcomes and cost for dialysis and non-dialysis patients hospitalized with CIED infections. Methods—We conducted a retrospective analysis of the Nationwide Inpatient Sample (NIS) discharge records from 2005 to 2010. Patients with CIED infections were identified using ICD-9 codes for device-related infections or device procedure along with bacteremia, endocarditis or systemic infection. Dialysis patients were identified using ICD-9 codes. Multivariable logistic and linear regressions were performed to examine in-hospital mortality, length of stay and cost. Results—Of the 87,798 estimated hospitalizations with CIED-infections, 6,665 (7.6 %) were dialysis patients. CIED-infection related hospitalization has increased over time among dialysis patients. In-hospital mortality was higher among dialysis patients (13.6% vs. 5.9%, p < 0.001). In the multivariable model, dialysis patients had higher odds of in-hospital mortality (odds ratio 1.98; 95% CI: 1.6, 2.4) compared to the non-dialysis group. Dialysis patients had longer median length of stay (12 days vs. 7 days, p
