HHS Public Access Author manuscript Author Manuscript
J Thorac Oncol. Author manuscript; available in PMC 2016 August 01. Published in final edited form as: J Thorac Oncol. 2015 August ; 10(8): 1201–1206. doi:10.1097/JTO.0000000000000600.
Outcomes following Stereotactic Body Radiotherapy vs. Limited Resection in Older Patients with Early Stage Lung Cancer Nicole Ezer1,2, Rajwanth R. Veluswamy2, Grace Mhango2, Kenneth E. Rosenzweig3, Charles A. Powell4, and Juan P. Wisnivesky2,3 1Department
of Medicine, Respiratory Division and Respiratory Epidemiology and Clinical Research Unit, McGill University, Montreal, Canada
Author Manuscript
2Divisions
of General Internal Medicine, Icahn School of Medicine at Mount Sinai
3Department
of Radiation Oncology, Icahn School of Medicine at Mount Sinai
4Pulmonary,
Critical Care, and Sleep Medicine, Icahn School of Medicine at Mount Sinai, New
York, NY
Abstract Background—Limited resection and stereotactic body radiotherapy (SBRT) have emerged as treatment options for older early stage non-small cell lung cancer (NSCLC) patients who are not good candidates for lobectomy.
Author Manuscript
Methods—We used the Surveillance, Epidemiology and End Results-Medicare registry to identify patients >65 years of age with stage I–II NSCLC and negative lymph nodes treated with SBRT vs. limited resection. We fitted a propensity score model predicting use of SBRT and compared adjusted overall survival of patients treated with SBRT vs. limited resection. Secondary analyses stratified the sample by type of limited resection (wedge vs. segmentectomy), age (≤75 vs. >75 years), and tumor size (