beg our frienda to join us in collecting material advantageous crusade may be made against this unrelenting foe. "We would fain amass and shape all the valuable information we possess on the past history of cholera, on its literature, on its causes, predisposing and exciting, on its origin, on the theories regarding the nature of its poison, on the phenomena of its outbreaks, the conditions favouring its invasion, progress, and diffusion, and on its choice of Atmospheric and meteorological condiparticular localities. tions must yet more be studied, as also questions of climate, season, temperature, moisture, direction of winds. Meanwhile Are

wherewith

an

The course of its from house to

visitations, village

from

from port to port, from

country, a

house,

the march

of the disease

to

village, from country to continent to continent, supplies

wide field of research.

greatest intensity, the conditions that tend transmission, the specific characters of so-called "Cholera fields;" their connection with miasm, with sewerage, with soil; the relation of Epidemics to the lines of human communication and to the course of rivers; the duration of its period of dormancy or incubation, all these The

periods

of its

to localize it or to favour its

are

points

on

which it remains for

us

to arrive at definite con-

clusions.

history of different Epidemics, the arguments for and against direct communicability, the characteristics of the disease at different places and at different times, the influence of site, of population, of high and low levels, of neglected sanitation, The

must also be gone into.

"We must consider of

more

deeply

than has yet been done the

prophylaxis hygienic precautions, the exact value Quarantine, of Cordon Kegulations, and of International Sanitary Codes. We need scarcely say that there yet remains much to be determined regarding the exact nature of its pathological lesions, and the characters and objects of the prolific cell-formation, which is the concomitant, if not the cause of Yolumes may yet be one of its most striking symptoms. written with advantage on the morbid appearances discover-

subject

and

of

able in those who have succumbed in different stages of the We would fain know the opinions of the Profession

disease.

OUR KNOWLEDGE OF CHOLERA. However meagre may be our really valuable knowledge of this terrible disease, there can be no doubt that great attention

being paid to the subject both in Europe and in India, It is sincerely to be hoped that the study that is now being bestowed on it may ere long lead to unquestionably important conclusions. The literature of the subject is yet sadly scattered, and in matters of detail, bearing on practice, there are well nigh as many opinions as men. It is full time that the collected observations and evidence on this important matter should be calmly sifted, and that we should be able to know what is accepted and what rejected by all good authorities. As Dr. John Macpherson has truly said, we ought to do this where the pestilence

is

ha3

its

home.

We

would draw

attention to

the Article

(which we publish in another column) on the Treatment and Pathology of this disease, by Dr. John Murray, InspectorGeneral of Hospitals, North-Western Provinces. We would invite eager and conscientious discussion regarding it. Want of time prevents our dwelling upon it at present as we should wish to do. In our next number we shall baye more to say.

regarding the views and theories of Dr. George " right or wrong in supposing that arrest of the to of the true is choleraic blood in the lungs key pathology " collapse ?" and doe3 this afford a complete explanation of all the most striking chemical phenomena of the disease ?" "What is the condition of the heart and lungs in collapse and reaction ? Is the left side empty and contracted?the right side distended with blood ? Is " choleraic collapse a form of asphyxia ?" These are now most interesting and vital questions. Again, what shall we say of treatment ? "What can we lay down authoritatively on the subject ? "What about venesection, evacuants, opium, castor-oil, calomel, saline injections, and the use of the sulphites? Wc beg our friends to take up these considerations in a zealous and philosophical spirit. Wo thank Dr. Murray for his communication, and we trust that in these columns light may yet be thrown on that terrible scourge which only last year amongst the pilgrims at Mecca accounted for a mortality which was variously estimated between 20,000

in

India

Johnson.

Is he

and 100,000.

Our Knowledge of Cholera.

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