JBRA Assisted Reproduction 2017;21(2):137-141 doi: 10.5935/1518-0557.20170030
Oral Presentations
Abstracts of the 13th Red Lara Taller General, Buenos Aires, Argentina, 26-28 April 2017
O-01. Zika Virus Outbreak -
Methods: Patients undergoing controlled ovarian stimulation (COS) for ICSI cycles in a university-affiliated in vitro fertilization center were split into age groups: ≤35 y.o. (n=1523); >35 and ≤38 y.o. (n=652); >38 and ≤40 y.o. (n=332); and >40 y.o. (n=370). The effect of FSH dose on COS, laboratorial and clinical outomes was determined by linear regression models. Results: The FSH dose didn’t affect the ovarian response in terms of total number of follicles, retrieved oocytes and mature oocytes within the age groups, but it was observed that the lower the age, the lower the FSH dose is needed per oocyte retrieved. In the group of patients ≤35 y.o., it was also noted a positive effect of FSH dose on oocyte yield. Despite that, for patients ≤38 y.o. it was verified a negative effect of FSH dose on embryo quality and blastocyst formation rate, and also an increase in cycle’s cancelation rate. In patients ≥ 39 y.o., there were no effects of the FSH doses on the analysed variables. Conclusion: The ovarian stimulation with high doses of FSH is not recommended in younger women (≤38 y.o.), once it was observed a decrease in embryo quality and an increase in cycle´s cancelation rate. Mild ovarian stimulation protocols may be more appropriate; however it may not be applicable for women in advanced age, since its necessary a higher FSH dose for oocyte retrieval in these patients.
Assisted reproduction patients should avoid pregnancy?
E. Borges Jr.1,2, D.P.A.F. Braga1,3, B.F. Zanetti1, A.S. Setti2, R.R. Provenza1, A. Iaconelli Jr.1 Fertility – Medical Group, São Paulo, SP – Brazil Instituto Sapientiae – Centro de Estudos e Pesquisa em Reprodução Humana Assistida, São Paulo, SP - Brazil 3 Disciplina de Urologia, Área de Reprodução Humana, Departamento de Cirurgia, Universidade Federal de São Paulo. - UNIFESP 1
2
Objective: To discuss the requirement of the National Health Surveillance Agency (ANVISA), to assisted reproduction treatment patients undergo laboratory tests for ZIKV detection, and also if it’s prudent the public health authorities and government leaders recommendation to women simply avoid pregnancy. Methods: This study was performed in a universityaffiliated In vitro fertilization center in Brazil. A critical discussion on the risk of microcephaly due to ZIKV infection and prevalence of others harmful pathogens to vulnerable pregnant women and infants was conducted. Moreover, 954 patients undergoing intracytoplasmic sperm injection cycles (ICSI), between April and November of 2016, were evaluated concerning the results of ZIKV test, according to the region of Brazil. Results: Patients undergoing ICSI cycles were split into groups according with region origin: 28 (3.0%) were from the North, 27 (2.8%) were from the Northeast, 40 (4.2%) were from the Central West, 830 (87.2%) were from Southeast, and 29 (3.0%) were from the South. Concerning the diagnosis, 112 samples had a positive or inconclusive result for ZIKV by chromatography immunoassay. These samples were re-analyzed by ELISA and none result was positive. All positive results were from the Southeast region and none from the Northeast or Central West regions, which are considered endemic regions. Conclusion: ZIKV test before the beginning of assisted reproduction treatments does not exclude the risk of the infection during pregnancy. In addition, although ZIKV infection risk is extremely high, the microcephaly risk due to ZIKV is not higher than the risk of miscarriage and birth defects due to other recognized pathogens.
O-03. The adverse effect of
overweight in Assisted Reproduction Outcomes
A.V. Sampo1, C. Palena1, L. Ganzer1, V. Maccari1, G. Estofán1, M. Hernández1 1 CIGOR – Centro Integral de Ginecología, Obstetricia y Reproducción. Córdoba, Argentina
Objective: To assess the effect of Body Mass Index (BMI) on the results obtained in ICSI cycles. Methods: We studied 266 ICSI cycles realized between January 2014 and December 2016. Patients were grouped according to their BMI in: Normal (18.5-24.9), Overweight (25.0- 29.9) and Obese (>30). We compared between the groups: antral follicles number, ovarian stimulation lenght, gonadotropin dose used, maximum oestradiol value, follicles developed /antral follicles, retrieved oocytes/developed follicles and mature/retrieved oocytes, normal fertilization rate, embryo achieved/ normal fertilized oocytes, clinical pregnancy and implantation rate. Kruskal-Wallis and Chi square test were used. P
Oral Presentations
Abstracts of the 13th Red Lara Taller General, Buenos Aires, Argentina, 26-28 April 2017
O-01. Zika Virus Outbreak -
Methods: Patients undergoing controlled ovarian stimulation (COS) for ICSI cycles in a university-affiliated in vitro fertilization center were split into age groups: ≤35 y.o. (n=1523); >35 and ≤38 y.o. (n=652); >38 and ≤40 y.o. (n=332); and >40 y.o. (n=370). The effect of FSH dose on COS, laboratorial and clinical outomes was determined by linear regression models. Results: The FSH dose didn’t affect the ovarian response in terms of total number of follicles, retrieved oocytes and mature oocytes within the age groups, but it was observed that the lower the age, the lower the FSH dose is needed per oocyte retrieved. In the group of patients ≤35 y.o., it was also noted a positive effect of FSH dose on oocyte yield. Despite that, for patients ≤38 y.o. it was verified a negative effect of FSH dose on embryo quality and blastocyst formation rate, and also an increase in cycle’s cancelation rate. In patients ≥ 39 y.o., there were no effects of the FSH doses on the analysed variables. Conclusion: The ovarian stimulation with high doses of FSH is not recommended in younger women (≤38 y.o.), once it was observed a decrease in embryo quality and an increase in cycle´s cancelation rate. Mild ovarian stimulation protocols may be more appropriate; however it may not be applicable for women in advanced age, since its necessary a higher FSH dose for oocyte retrieval in these patients.
Assisted reproduction patients should avoid pregnancy?
E. Borges Jr.1,2, D.P.A.F. Braga1,3, B.F. Zanetti1, A.S. Setti2, R.R. Provenza1, A. Iaconelli Jr.1 Fertility – Medical Group, São Paulo, SP – Brazil Instituto Sapientiae – Centro de Estudos e Pesquisa em Reprodução Humana Assistida, São Paulo, SP - Brazil 3 Disciplina de Urologia, Área de Reprodução Humana, Departamento de Cirurgia, Universidade Federal de São Paulo. - UNIFESP 1
2
Objective: To discuss the requirement of the National Health Surveillance Agency (ANVISA), to assisted reproduction treatment patients undergo laboratory tests for ZIKV detection, and also if it’s prudent the public health authorities and government leaders recommendation to women simply avoid pregnancy. Methods: This study was performed in a universityaffiliated In vitro fertilization center in Brazil. A critical discussion on the risk of microcephaly due to ZIKV infection and prevalence of others harmful pathogens to vulnerable pregnant women and infants was conducted. Moreover, 954 patients undergoing intracytoplasmic sperm injection cycles (ICSI), between April and November of 2016, were evaluated concerning the results of ZIKV test, according to the region of Brazil. Results: Patients undergoing ICSI cycles were split into groups according with region origin: 28 (3.0%) were from the North, 27 (2.8%) were from the Northeast, 40 (4.2%) were from the Central West, 830 (87.2%) were from Southeast, and 29 (3.0%) were from the South. Concerning the diagnosis, 112 samples had a positive or inconclusive result for ZIKV by chromatography immunoassay. These samples were re-analyzed by ELISA and none result was positive. All positive results were from the Southeast region and none from the Northeast or Central West regions, which are considered endemic regions. Conclusion: ZIKV test before the beginning of assisted reproduction treatments does not exclude the risk of the infection during pregnancy. In addition, although ZIKV infection risk is extremely high, the microcephaly risk due to ZIKV is not higher than the risk of miscarriage and birth defects due to other recognized pathogens.
O-03. The adverse effect of
overweight in Assisted Reproduction Outcomes
A.V. Sampo1, C. Palena1, L. Ganzer1, V. Maccari1, G. Estofán1, M. Hernández1 1 CIGOR – Centro Integral de Ginecología, Obstetricia y Reproducción. Córdoba, Argentina
Objective: To assess the effect of Body Mass Index (BMI) on the results obtained in ICSI cycles. Methods: We studied 266 ICSI cycles realized between January 2014 and December 2016. Patients were grouped according to their BMI in: Normal (18.5-24.9), Overweight (25.0- 29.9) and Obese (>30). We compared between the groups: antral follicles number, ovarian stimulation lenght, gonadotropin dose used, maximum oestradiol value, follicles developed /antral follicles, retrieved oocytes/developed follicles and mature/retrieved oocytes, normal fertilization rate, embryo achieved/ normal fertilized oocytes, clinical pregnancy and implantation rate. Kruskal-Wallis and Chi square test were used. P
