Vaccine 32 (2014) 478–482

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Vaccine journal homepage: www.elsevier.com/locate/vaccine

Oral polio vaccine response in breast fed infants with malnutrition and diarrhea Rashidul Haque a , Cynthia Snider b , Yue Liu b , Jennie Z. Ma b , Lei Liu c , Uma Nayak b , Josyf C. Mychaleckyj b , Poonum Korpe b , Dinesh Mondal a , Mamun Kabir a , Masud Alam a , Mark Pallansch d , M. Steven Oberste d , William Weldon d , Beth D. Kirkpatrick e , William A. Petri Jr. b,∗ a

International Centre for Diarrhoeal Disease Research, Dhaka, Bangladesh University of Virginia, Charlottesville, Virginia, USA c Northwestern University, Chicago, IL, USA d Centers for Disease Control and Prevention, Atlanta, Georgia, USA e University of Vermont College of Medicine, Burlington, Vermont, USA b

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Article history: Received 25 July 2013 Received in revised form 10 November 2013 Accepted 15 November 2013 Available online 2 December 2013

a b s t r a c t Oral vaccines for polio (OPV) and rotavirus are less effective in children in the developing world. The reasons for this are not well understood. We tested for risk factors for poor response to OPV in infants from an urban slum of Dhaka, Bangladesh. Diminished serum neutralizing response to OPV, but not failure of intramuscularly administered vaccines, was associated with malnutrition, diarrhea, and shorter breastfeeding duration. Children with malnutrition (WAZ

Oral polio vaccine response in breast fed infants with malnutrition and diarrhea.

Oral vaccines for polio (OPV) and rotavirus are less effective in children in the developing world. The reasons for this are not well understood. We t...
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