trririsn Journal of Obstetrics and Gynaecology March 1992, Vol. 99, pp. 239-246
FERTILITY C O N T R O L
Oral contraceptive use and breast cancer risk: a metaanalysis of variations with age at diagnosis, parity and total duration of oral contraceptive use LESLEY RUSHTON Research Fellow DAVID R . J O N E S Reader iiz Epidemiology Department of Public Health Sciences St George’s Hospital Medical School London SW 17 ORE, UK
ABSTRACT Objective To review published reports of risk of breast cancer with oral contraceptive use. Design Meta-analysis of study results, using regression techniques to explore the inter-studY heterogeneity. Setting Twenty-seven epidemiological studies of breast cancer risk and oral contraceptive use published 1980-1989. Main outcome measures Relative risk of breast cancer with oral contraceptive use; variations by age at diagnosis, parity, and total duration of use, and with study design characteristics. Results The overall relative risk estimate was 1.16 (95% CI 1.07-1.25) for the
FERTILITY C O N T R O L
Oral contraceptive use and breast cancer risk: a metaanalysis of variations with age at diagnosis, parity and total duration of oral contraceptive use LESLEY RUSHTON Research Fellow DAVID R . J O N E S Reader iiz Epidemiology Department of Public Health Sciences St George’s Hospital Medical School London SW 17 ORE, UK
ABSTRACT Objective To review published reports of risk of breast cancer with oral contraceptive use. Design Meta-analysis of study results, using regression techniques to explore the inter-studY heterogeneity. Setting Twenty-seven epidemiological studies of breast cancer risk and oral contraceptive use published 1980-1989. Main outcome measures Relative risk of breast cancer with oral contraceptive use; variations by age at diagnosis, parity, and total duration of use, and with study design characteristics. Results The overall relative risk estimate was 1.16 (95% CI 1.07-1.25) for the
