VIDEOGIE Todd H. Baron, MD, G. S. Raju, MD, Editors for VideoGIE
Optical frequency domain imaging in patients with Barrett’s neoplasia: an ex vivo case study with correlated endoscopic and histology views
Figure 1. Optical frequency domain interferometry image of Barrett’s esophagus.
This video (Video 1, available online at www.giejournal. org) describes the optical frequency domain interferometry (OFDI) imaging technique, which is a U.S. Food and Drug Administration–approved and commercially available second-generation of optical coherence tomography, and its close correlation with endoscopic views and histopathology results in patients with Barrett’s esophagus. OFDI uses frequency-based measurements between the emission and reception of near-infrared light to acquire 3-dimensional volumetric microscopic images of the distal 6 cm of the esophagus up to a resolution of 10 mm in 2 minutes. We used OFDI to detect ex vivo dysplastic Barrett’s esophagus of an endoscopically resected mucosal specimen from an 80-year-old woman. Initial EGD showed a 1-cm segment of Barrett’s esophagus with dysplastic glandular and vascular changes. EUS showed no abnormality. Histopathology results from this resected specimen found Barrett’s esophagus with high-grade dysplasia. The full length of this specimen was then scanned by use of OFDI, which showed loss of layering and abnormal surface
www.giejournal.org
maturation near the surface (this appeared darker than the deeper layers) and abnormal glandular distribution in the mucosal layer. This is characteristic of neoplastic Barrett’s esophagus. We concluded that OFDI may provide a means to evaluate pathologic states of the esophageal mucosa in real time. DISCLOSURE H. Wolfsen and M. Wallace received financial support from Nine Points Medical. No other financial relationships relevant to this publication were disclosed. Waseem J. David, MD, Herbert C. Wolfsen, MD, Murli Krishna, MD, Michael B. Wallace, MD, MPH, Division of Gastroenterology and Hepatology, Mayo Clinic Florida, Jacksonville, Florida, USA
http://dx.doi.org/10.1016/j.gie.2014.02.1023
Volume
-,
No.
-
: 2014 GASTROINTESTINAL ENDOSCOPY 1
Optical frequency domain imaging in patients with Barrett’s neoplasia: an ex vivo case study with correlated endoscopic and histology views
Figure 1. Optical frequency domain interferometry image of Barrett’s esophagus.
This video (Video 1, available online at www.giejournal. org) describes the optical frequency domain interferometry (OFDI) imaging technique, which is a U.S. Food and Drug Administration–approved and commercially available second-generation of optical coherence tomography, and its close correlation with endoscopic views and histopathology results in patients with Barrett’s esophagus. OFDI uses frequency-based measurements between the emission and reception of near-infrared light to acquire 3-dimensional volumetric microscopic images of the distal 6 cm of the esophagus up to a resolution of 10 mm in 2 minutes. We used OFDI to detect ex vivo dysplastic Barrett’s esophagus of an endoscopically resected mucosal specimen from an 80-year-old woman. Initial EGD showed a 1-cm segment of Barrett’s esophagus with dysplastic glandular and vascular changes. EUS showed no abnormality. Histopathology results from this resected specimen found Barrett’s esophagus with high-grade dysplasia. The full length of this specimen was then scanned by use of OFDI, which showed loss of layering and abnormal surface
www.giejournal.org
maturation near the surface (this appeared darker than the deeper layers) and abnormal glandular distribution in the mucosal layer. This is characteristic of neoplastic Barrett’s esophagus. We concluded that OFDI may provide a means to evaluate pathologic states of the esophageal mucosa in real time. DISCLOSURE H. Wolfsen and M. Wallace received financial support from Nine Points Medical. No other financial relationships relevant to this publication were disclosed. Waseem J. David, MD, Herbert C. Wolfsen, MD, Murli Krishna, MD, Michael B. Wallace, MD, MPH, Division of Gastroenterology and Hepatology, Mayo Clinic Florida, Jacksonville, Florida, USA
http://dx.doi.org/10.1016/j.gie.2014.02.1023
Volume
-,
No.
-
: 2014 GASTROINTESTINAL ENDOSCOPY 1
