LETTERS TO THE EDITOR CONGENITAL URINARY AND MYELODYSPLASIA
ANOMALIES
To the Editor: We read with interest the report by Kreder et al.’ on anomalies associated with myelodysplasia. We recently reported our experience with congenital urinary abnormalities associated with neural tube defects2 We found significant urinary abnormalities in 11 of 178 children (6%) with a neural tube defect. The pattern of renal malformations observed by Kreder et al.’ conforms to that observed by us and other authors.2-4 The most common renal abnormalities observed are those of fusion and migration (horseshoe kidney, pelvic kidney, crossed ectopia) followed by abnormalities of formation (atresia, dysplasia). We also observed congenital lower urinary tract abnormalities including cloacal anomaly and urethral atresia. 2 We recommend that all children with a neural tube defect have an ultrasound of the urinary tract performed to look for associated congenital urinary abnormalities. Wm. LaneM. Robson, M.D., ER.C.F!(C), F.R.S.H. Alexander K. C. Leung, M.B.B.S., ER.C.P (Edin) Ollie J. Sinclair, R.N. Departments of Pediatrics and Nursing University of Calgary Alberta Children’s Hospital Calgary, Alberta, Canada T2W 3M6
1. Kreder KJ, et ol: Anomalies associated with Urology 39: 24% (1992). 2. Rohson WLM. Leune AKC. and Sinclair urinary abnormal&s and~neurai tube defects, Urol 11: 84 (1991). 3. Hulton SA, et al: The pattern of congenital associated with neural tube defects, Pediatr (1990).
292
4. Hunt CM, and Whitaker RH: The pattern of congenital renal anomalies associated with neural tube defects, Dev Med Child Neurol 29: 91 (1987).
OPHTHALMOLOGIC GU DISEASE
renal anomalies Nephrol 4: 491
OF
To the Editor: I read the article by S. Rowe, S. Siegel, and W. Benedict on Ophthalmologic Manifestations of Genitourinary Diseases, published in the June issue (vol. 39, pages 523-525, 1992) of UROLOGY.
I would like to add that one must also look for ophthalmopathy of Graves disease, since testis cancers are known to cause hyperthyroidism.1,2 Steigbigel et al.’ reported in 1964 on a male patient with hyperthyroidism associated with embryonal cell cancer of the testis and a high serum level of human chorionic gonadotropin (hCG) . Dorr2 reported on a case of hyperthyroidism in a patient with embryonal cell carcinoma who had elevated BhCG, which had thyrotropic activity sufficient to cause hyperthyroidism because BhCG is functionally similar to thyrotropin. M. R. Shetty, M.D. Northwest Community Hospital 800 West Central Road Arlington Heights, IL 60005-2392 References
myelodysplasia, ._ 01: Congenital Child Niphrol
MANIFESTATIONS
1. Steigbigel NH, Oppenheim JJ, Fishman LM, and Carbone PP: MetastaGc embryonal carcinoma of the testis associated with elevated dasma TSH-like activitv and hvnerthvroidism. N Enel T ’ - Med 271: 345349 (1964). ’ ’’ 2. Dorr MM: Hyperthyroidism associated with testicular embryonal carcinoma and elevated serum human chorionic gonadotropin, Northwest Community Hosp Bull 18: 88-95 (1991).
UROLOGY
I
SEPTEMBER
1992
I
VOLUME
40, NUMBER
3
ANOMALIES
To the Editor: We read with interest the report by Kreder et al.’ on anomalies associated with myelodysplasia. We recently reported our experience with congenital urinary abnormalities associated with neural tube defects2 We found significant urinary abnormalities in 11 of 178 children (6%) with a neural tube defect. The pattern of renal malformations observed by Kreder et al.’ conforms to that observed by us and other authors.2-4 The most common renal abnormalities observed are those of fusion and migration (horseshoe kidney, pelvic kidney, crossed ectopia) followed by abnormalities of formation (atresia, dysplasia). We also observed congenital lower urinary tract abnormalities including cloacal anomaly and urethral atresia. 2 We recommend that all children with a neural tube defect have an ultrasound of the urinary tract performed to look for associated congenital urinary abnormalities. Wm. LaneM. Robson, M.D., ER.C.F!(C), F.R.S.H. Alexander K. C. Leung, M.B.B.S., ER.C.P (Edin) Ollie J. Sinclair, R.N. Departments of Pediatrics and Nursing University of Calgary Alberta Children’s Hospital Calgary, Alberta, Canada T2W 3M6
1. Kreder KJ, et ol: Anomalies associated with Urology 39: 24% (1992). 2. Rohson WLM. Leune AKC. and Sinclair urinary abnormal&s and~neurai tube defects, Urol 11: 84 (1991). 3. Hulton SA, et al: The pattern of congenital associated with neural tube defects, Pediatr (1990).
292
4. Hunt CM, and Whitaker RH: The pattern of congenital renal anomalies associated with neural tube defects, Dev Med Child Neurol 29: 91 (1987).
OPHTHALMOLOGIC GU DISEASE
renal anomalies Nephrol 4: 491
OF
To the Editor: I read the article by S. Rowe, S. Siegel, and W. Benedict on Ophthalmologic Manifestations of Genitourinary Diseases, published in the June issue (vol. 39, pages 523-525, 1992) of UROLOGY.
I would like to add that one must also look for ophthalmopathy of Graves disease, since testis cancers are known to cause hyperthyroidism.1,2 Steigbigel et al.’ reported in 1964 on a male patient with hyperthyroidism associated with embryonal cell cancer of the testis and a high serum level of human chorionic gonadotropin (hCG) . Dorr2 reported on a case of hyperthyroidism in a patient with embryonal cell carcinoma who had elevated BhCG, which had thyrotropic activity sufficient to cause hyperthyroidism because BhCG is functionally similar to thyrotropin. M. R. Shetty, M.D. Northwest Community Hospital 800 West Central Road Arlington Heights, IL 60005-2392 References
myelodysplasia, ._ 01: Congenital Child Niphrol
MANIFESTATIONS
1. Steigbigel NH, Oppenheim JJ, Fishman LM, and Carbone PP: MetastaGc embryonal carcinoma of the testis associated with elevated dasma TSH-like activitv and hvnerthvroidism. N Enel T ’ - Med 271: 345349 (1964). ’ ’’ 2. Dorr MM: Hyperthyroidism associated with testicular embryonal carcinoma and elevated serum human chorionic gonadotropin, Northwest Community Hosp Bull 18: 88-95 (1991).
UROLOGY
I
SEPTEMBER
1992
I
VOLUME
40, NUMBER
3
