Endocrine Care 473
Authors
F. D. Desgorces1, 2, 3, C. Le Page1, 3, 4, C. Police1, 3, N. Neveux1, 5, 6, C. H. Cottart1, 5, 7, M. C. Blanc1, 5, 6, J. Raison8, J. F. Toussaint1, 2, 9, P. Noirez1, 2, 3, 5
Affiliations
Affiliation addresses are listed at the end of the article
Key words ▶ body weight ● ▶ leptin ● ▶ insulin resistance ● ▶ exercise ● ▶ nutrition ●
Abstract
received 17.03.2014 accepted 21.07.2014 Bibliography DOI http://dx.doi.org/ 10.1055/s-0034-1387704 Published online: August 25, 2014 Horm Metab Res 2015; 47: 473–478 © Georg Thieme Verlag KG Stuttgart · New York ISSN 0018-5043 Correspondence F. D. Desgorces IRMES, INSEP 11 avenue du Tremblay 75012 Paris France Tel.: + 33/1/5656 1278 Fax: + 33/1/5656 1200 francois.desgorces@ parisdescartes.fr
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Perturbations of energy balance induce compensatory processes that may alter expected weight loss. In obese patients, our aim was to investigate the relationships that occurred between fasting plasma concentrations of anorexigenic peptides and metabolic parameters, appetite, physical capacity, and weight loss in the 5 first days of a program associating exercise and caloric reduction. Thirteen obese women were monitored from day 1 to day 5 with 2 exercise sessions in day 2 and day 4. We measured, in a fasted state, changes in body weight, hunger ratings, and plasma concentrations of fatty acids, triglycerides, leptin, insulin, amylin, peptide YY, and insulin-resistance index. Physical performance was assessed by a 6-min walking test. The program resulted in significantly reduced body weight (0.75 ± 0.4 kg; p = 0.001), of plasma concentrations of triglycerides, insulin, amylin, peptide YY,
Introduction
▼
Dietary restriction combined with physical exercise represents an effective strategy to lose weight and reduce fat mass in obese patients [1]. Exercise plus dietary restriction prevents a decrease in fat-free mass, increases relative visceral fat-mass loss, and maintains weight loss improving appetite control and behavioral practices [2, 3]. However, weight-loss programs that lead to energy deficits of 500–1 000 kcal/day or more may induce the regulatory system to defend against energy deprivation [3, 4]. These compensatory responses to a negative energy balance appear to be highly effective in some individuals and can render them resistant to weight loss. Therefore, although exercise and diet interventions are good strategies to reduce obesity, some individuals lose weight whereas others do not.
and the insulin-resistance index, and also increased fatty acids (p
Authors
F. D. Desgorces1, 2, 3, C. Le Page1, 3, 4, C. Police1, 3, N. Neveux1, 5, 6, C. H. Cottart1, 5, 7, M. C. Blanc1, 5, 6, J. Raison8, J. F. Toussaint1, 2, 9, P. Noirez1, 2, 3, 5
Affiliations
Affiliation addresses are listed at the end of the article
Key words ▶ body weight ● ▶ leptin ● ▶ insulin resistance ● ▶ exercise ● ▶ nutrition ●
Abstract
received 17.03.2014 accepted 21.07.2014 Bibliography DOI http://dx.doi.org/ 10.1055/s-0034-1387704 Published online: August 25, 2014 Horm Metab Res 2015; 47: 473–478 © Georg Thieme Verlag KG Stuttgart · New York ISSN 0018-5043 Correspondence F. D. Desgorces IRMES, INSEP 11 avenue du Tremblay 75012 Paris France Tel.: + 33/1/5656 1278 Fax: + 33/1/5656 1200 francois.desgorces@ parisdescartes.fr
▼
Perturbations of energy balance induce compensatory processes that may alter expected weight loss. In obese patients, our aim was to investigate the relationships that occurred between fasting plasma concentrations of anorexigenic peptides and metabolic parameters, appetite, physical capacity, and weight loss in the 5 first days of a program associating exercise and caloric reduction. Thirteen obese women were monitored from day 1 to day 5 with 2 exercise sessions in day 2 and day 4. We measured, in a fasted state, changes in body weight, hunger ratings, and plasma concentrations of fatty acids, triglycerides, leptin, insulin, amylin, peptide YY, and insulin-resistance index. Physical performance was assessed by a 6-min walking test. The program resulted in significantly reduced body weight (0.75 ± 0.4 kg; p = 0.001), of plasma concentrations of triglycerides, insulin, amylin, peptide YY,
Introduction
▼
Dietary restriction combined with physical exercise represents an effective strategy to lose weight and reduce fat mass in obese patients [1]. Exercise plus dietary restriction prevents a decrease in fat-free mass, increases relative visceral fat-mass loss, and maintains weight loss improving appetite control and behavioral practices [2, 3]. However, weight-loss programs that lead to energy deficits of 500–1 000 kcal/day or more may induce the regulatory system to defend against energy deprivation [3, 4]. These compensatory responses to a negative energy balance appear to be highly effective in some individuals and can render them resistant to weight loss. Therefore, although exercise and diet interventions are good strategies to reduce obesity, some individuals lose weight whereas others do not.
and the insulin-resistance index, and also increased fatty acids (p
