Molecular BioSystems View Article Online
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Cite this: Mol. BioSyst., 2014, 10, 1226
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One medicine – one health – one biology and many proteins: proteomics on the verge of the One Health approach
Published on 29 April 2014. Downloaded on 28/10/2014 12:22:24.
Paola Roncada,a Alessandra Modesti,b Anna Maria Timperio,c Luca Bini,d Massimo Castagnola,ef Mauro Fasanog and Andrea Urbani*hi Starting from Hippocrates, at the Age of Pericles, the One Health initiative takes inspiration from the Greek father of medicine and is based on his approach which recognizes that human health, animal health and environmental health are part of a whole body. Chiron, the wisest of all centaurs, is the classical mythological representation of an integrated view between man and the environment. Thus, he is the tangible example of the Hippocratic dyad where healthcare is achieved by the integration of man DOI: 10.1039/c4mb90011a
with nature. As a mythological Chiron in modern systems medicine, the integrated body of evidence in proteomics investigations is providing key molecular and analytical knowledge to achieve an evidence
www.rsc.org/molecularbiosystems
based approach. Hereafter we introduce some examples published in this themed proteomics issue.
The legacy of Chiron in modern systems medicine may well be represented as the molecular and analytical knowledge provided by proteomics investigations in healthcare. Chiron, the wisest of all centaurs, is the classical mythological representation of an integrated view between man and the environment. He is the tangible example of the Hippocratic dyad where healthcare is achieved by the integration of man with the environment. a
Section of Proteomics, Istituto Sperimentale Italiano L. Spallanzani, University of Milano, Milan, Italy b Department of Biochemical Sciences, University of Florence, Italy c Dipartimento di Scienze Ambientali, ` della Tuscia, Viterbo, Italy Universita d Department of Biotechnologies, University of Siena, Italy e Istituto di Biochimica e di Biochimica Clinica, ` Cattolica, Rome, Italy Universita f Istituto di Chimica del Riconoscimento Molecolare, CNR, Rome, Italy g Department of Theoretical and Applied Sciences, and Center of Neuroscience, University of Insubria, Busto Arsizio, Italy h Department of Experimental Medicine and Surgery, University of Rome ‘‘Tor Vergata’’, Via Montpellier 1, 00133 Rome, Italy. E-mail: [email protected]; Fax: +39-06-501703332 i IRCCS-Fondazione S. Lucia, Rome, Italy
1226 | Mol. BioSyst., 2014, 10, 1226--1227
The One Health initiative takes inspiration from the Greek father of medicine and is based on his approach which recognizes that human health, animal health and environmental health are parts of a whole body. Thus, the health and well-being of all species are inextricably linked and the development of cooperative research efforts between physicians, veterinarians, and other scientific health and environmental professionals are necessary to set this vision into practice. The development of an evidence-based approach in this field and the analytical description of the molecular mechanisms underlining this vision are fundamental in order to achieve a scientific initiative. In this light, proteomics investigations are providing an initial insight into the molecular definition of such a large complexity. In this themed issue dedicated to proteomics, we have a clear example of such an integrative network of relationships. Following the Chiron, the well renowned corporate enterprise that was sequencing and patenting the first HCV viral genome in 1987, has arrived at the definition of the intrinsic disorder status of HCV proteome in 2014. The paper by
Xiao Fan et al. (DOI: 10.1039/ C4MB00027G) in fact provides an interesting theoretical analysis on the predicted intrinsic disorder status of different proteins encoded in the RNA+ genome of HCV, which may represent the biological medium saxum for the subtle escaping mechanisms of this virus. Within the host–commensal interaction mechanisms, the paradigm introduced by E. Mangiapane et al. (DOI: 10.1039/C3MB70557A) in the description of the proteome arrangement enabling the transport of organic selenium forms in human body, represents an interesting perspective in the nutraceutical field. The effects of selenium on probiotic cells is investigated, in order to elucidate the mechanisms involved in Se metabolism and to exclude possible harmful effects. Furthermore, in the global view of the One Health approach, the animal production connected to sustainability and improved methods of selection are focused on in the paper by De Canio et al. (DOI: 10.1039/C3MB70306A). Natural extracted components have a long history of applications in medicinal chemistry; more recently, the many functional targets of their actions have been examined. Such
This journal is © The Royal Society of Chemistry 2014
View Article Online
Editorial
activation of multiple receptors is not always available. The paper from D’Alessandro et al. (DOI: 10.1039/C3MB70362B) provides an interesting metabolic overview in this respect. The close interlinkage between metabolism and neuroscience is further explored in the papers dedicated to the Mitochondrial Human Proteome Project (Mt-HPP) initiative promoted by the Italian Proteomics Association (ItPA). The impact of dopamine administration on neuronal-like cell models evaluated by T. Alberio et al. (DOI: 10.1039/C3MB70611G) and the work by C. Musicco et al.
(DOI: 10.1039/C3MB70542K) on cybrid cellular models of complex I disorders represent the first products of this action. Moreover, following the first Mt-HPP workshop during the Padova Annual ItPA Congress in June 2013, a new impetus in the scientific community has brought about new investigations on this prime example of symbiotic integration. In this light, the manuscript from L. Giusti et al. (DOI: 10.1039/C4MB00068D) suggests the possible involvement of mitochondrial functions in the lymphocytes of patients with acute psychotic bipolar disorder.
Published on 29 April 2014. Downloaded on 28/10/2014 12:22:24.
an effort is also pursued in two papers in this collection which aim to redefine the possible molecular mechanisms of both the cancer chemopreventive and chemotherapeutic effects of curcumin (DOI: 10.1039/ C3MB70553F) and strawberry extracts (DOI: 10.1039/C3MB70316A). The large plethora of therapeutic potentials of natural substances reside in the multiplicity of their receptors and of the transduction pathways they activate. Neuropeptides display high specificity for their receptors and have minimal cross-reactivity. Nevertheless, their synergic and combined impact on the
Molecular BioSystems
This journal is © The Royal Society of Chemistry 2014
Mol. BioSyst., 2014, 10, 1226--1227 | 1227
EDITORIAL
Cite this: Mol. BioSyst., 2014, 10, 1226
View Journal | View Issue
One medicine – one health – one biology and many proteins: proteomics on the verge of the One Health approach
Published on 29 April 2014. Downloaded on 28/10/2014 12:22:24.
Paola Roncada,a Alessandra Modesti,b Anna Maria Timperio,c Luca Bini,d Massimo Castagnola,ef Mauro Fasanog and Andrea Urbani*hi Starting from Hippocrates, at the Age of Pericles, the One Health initiative takes inspiration from the Greek father of medicine and is based on his approach which recognizes that human health, animal health and environmental health are part of a whole body. Chiron, the wisest of all centaurs, is the classical mythological representation of an integrated view between man and the environment. Thus, he is the tangible example of the Hippocratic dyad where healthcare is achieved by the integration of man DOI: 10.1039/c4mb90011a
with nature. As a mythological Chiron in modern systems medicine, the integrated body of evidence in proteomics investigations is providing key molecular and analytical knowledge to achieve an evidence
www.rsc.org/molecularbiosystems
based approach. Hereafter we introduce some examples published in this themed proteomics issue.
The legacy of Chiron in modern systems medicine may well be represented as the molecular and analytical knowledge provided by proteomics investigations in healthcare. Chiron, the wisest of all centaurs, is the classical mythological representation of an integrated view between man and the environment. He is the tangible example of the Hippocratic dyad where healthcare is achieved by the integration of man with the environment. a
Section of Proteomics, Istituto Sperimentale Italiano L. Spallanzani, University of Milano, Milan, Italy b Department of Biochemical Sciences, University of Florence, Italy c Dipartimento di Scienze Ambientali, ` della Tuscia, Viterbo, Italy Universita d Department of Biotechnologies, University of Siena, Italy e Istituto di Biochimica e di Biochimica Clinica, ` Cattolica, Rome, Italy Universita f Istituto di Chimica del Riconoscimento Molecolare, CNR, Rome, Italy g Department of Theoretical and Applied Sciences, and Center of Neuroscience, University of Insubria, Busto Arsizio, Italy h Department of Experimental Medicine and Surgery, University of Rome ‘‘Tor Vergata’’, Via Montpellier 1, 00133 Rome, Italy. E-mail: [email protected]; Fax: +39-06-501703332 i IRCCS-Fondazione S. Lucia, Rome, Italy
1226 | Mol. BioSyst., 2014, 10, 1226--1227
The One Health initiative takes inspiration from the Greek father of medicine and is based on his approach which recognizes that human health, animal health and environmental health are parts of a whole body. Thus, the health and well-being of all species are inextricably linked and the development of cooperative research efforts between physicians, veterinarians, and other scientific health and environmental professionals are necessary to set this vision into practice. The development of an evidence-based approach in this field and the analytical description of the molecular mechanisms underlining this vision are fundamental in order to achieve a scientific initiative. In this light, proteomics investigations are providing an initial insight into the molecular definition of such a large complexity. In this themed issue dedicated to proteomics, we have a clear example of such an integrative network of relationships. Following the Chiron, the well renowned corporate enterprise that was sequencing and patenting the first HCV viral genome in 1987, has arrived at the definition of the intrinsic disorder status of HCV proteome in 2014. The paper by
Xiao Fan et al. (DOI: 10.1039/ C4MB00027G) in fact provides an interesting theoretical analysis on the predicted intrinsic disorder status of different proteins encoded in the RNA+ genome of HCV, which may represent the biological medium saxum for the subtle escaping mechanisms of this virus. Within the host–commensal interaction mechanisms, the paradigm introduced by E. Mangiapane et al. (DOI: 10.1039/C3MB70557A) in the description of the proteome arrangement enabling the transport of organic selenium forms in human body, represents an interesting perspective in the nutraceutical field. The effects of selenium on probiotic cells is investigated, in order to elucidate the mechanisms involved in Se metabolism and to exclude possible harmful effects. Furthermore, in the global view of the One Health approach, the animal production connected to sustainability and improved methods of selection are focused on in the paper by De Canio et al. (DOI: 10.1039/C3MB70306A). Natural extracted components have a long history of applications in medicinal chemistry; more recently, the many functional targets of their actions have been examined. Such
This journal is © The Royal Society of Chemistry 2014
View Article Online
Editorial
activation of multiple receptors is not always available. The paper from D’Alessandro et al. (DOI: 10.1039/C3MB70362B) provides an interesting metabolic overview in this respect. The close interlinkage between metabolism and neuroscience is further explored in the papers dedicated to the Mitochondrial Human Proteome Project (Mt-HPP) initiative promoted by the Italian Proteomics Association (ItPA). The impact of dopamine administration on neuronal-like cell models evaluated by T. Alberio et al. (DOI: 10.1039/C3MB70611G) and the work by C. Musicco et al.
(DOI: 10.1039/C3MB70542K) on cybrid cellular models of complex I disorders represent the first products of this action. Moreover, following the first Mt-HPP workshop during the Padova Annual ItPA Congress in June 2013, a new impetus in the scientific community has brought about new investigations on this prime example of symbiotic integration. In this light, the manuscript from L. Giusti et al. (DOI: 10.1039/C4MB00068D) suggests the possible involvement of mitochondrial functions in the lymphocytes of patients with acute psychotic bipolar disorder.
Published on 29 April 2014. Downloaded on 28/10/2014 12:22:24.
an effort is also pursued in two papers in this collection which aim to redefine the possible molecular mechanisms of both the cancer chemopreventive and chemotherapeutic effects of curcumin (DOI: 10.1039/ C3MB70553F) and strawberry extracts (DOI: 10.1039/C3MB70316A). The large plethora of therapeutic potentials of natural substances reside in the multiplicity of their receptors and of the transduction pathways they activate. Neuropeptides display high specificity for their receptors and have minimal cross-reactivity. Nevertheless, their synergic and combined impact on the
Molecular BioSystems
This journal is © The Royal Society of Chemistry 2014
Mol. BioSyst., 2014, 10, 1226--1227 | 1227
