Accepted Manuscript Obstructing Ventral Hernias Are Not Independently Associated with Surgical Site Infections Megan Sippey, MD, Anthony B. Mozer, MD, Marysia Grzybowski, PhD, MPH, BSN, Mark L. Manwaring, MD, Kevin R. Kasten, MD, Gina L. Adrales, MD, MPH, Konstantinos Spaniolas, MD PII:

S0022-4804(15)00508-9

DOI:

10.1016/j.jss.2015.04.079

Reference:

YJSRE 13341

To appear in:

Journal of Surgical Research

Received Date: 6 January 2015 Revised Date:

20 March 2015

Accepted Date: 21 April 2015

Please cite this article as: Sippey M, Mozer AB, Grzybowski M, Manwaring ML, Kasten KR, Adrales GL, Spaniolas K, Obstructing Ventral Hernias Are Not Independently Associated with Surgical Site Infections, Journal of Surgical Research (2015), doi: 10.1016/j.jss.2015.04.079. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

ACCEPTED MANUSCRIPT 1 Revised 3/20/15 Title: Obstructing Ventral Hernias Are Not Independently Associated with Surgical Site Infections Authors: 1

Megan Sippey, MD

Marysia Grzybowski, PhD, MPH, BSN

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1 1

1

Mark L. Manwaring, MD 1

Kevin R. Kasten, MD

Gina L. Adrales, MD, MPH2 1

Konstantinos Spaniolas, MD 1

Brody School of Medicine at East Carolina University

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Department of Surgery

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Anthony B. Mozer, MD

600 Moye Boulevard Greenville, NC 27834 United States of America

[email protected], [email protected], [email protected], [email protected], [email protected], [email protected] 2

Department of Surgery 1 Medical Center Drive Lebanon, NH 03756

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United States of America

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Dartmouth-Hitchcock Medical Center

[email protected]

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Corresponding author contact information: Konstantinos Spaniolas

Brody School of Medicine at East Carolina University Department of Surgery 600 Moye Boulevard

Greenville, NC 27834 United States of America Phone (252) 744-0292 Fax (252) 744-5775 [email protected]

ACCEPTED MANUSCRIPT 2 Author Contributions: Drs. Adrales and Spaniolas were responsible for the conception and design of this work. Drs. Adrales, Spaniolas, Sippey, Mozer, Grzybowski, Manwaring, and Kasten contributed to the acquisition, analysis and interpretation of the work. Dr. Sippey was responsible for drafting the

revising it critically for important intellectual content.

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Author disclosure statement:

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work and Drs. Adrales, Spaniolas, Mozer, Grzybowski, Manwaring, and Kasten contributed to

Authors of this study have no conflicts of interest to report. The authors report no proprietary or

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received no external funding.

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commercial interest in any product mentioned or concept discussed in this article. This study

ACCEPTED MANUSCRIPT 3 Obstructing Ventral Hernias Are Not Independently Associated with Surgical Site Infections

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Megan Sippey, Anthony Mozer, Marysia Grzybowski, Mark Manwaring, Kevin Kasten, Gina Adrales, Konstantinos Spaniolas

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Abstract

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Background: Delayed operative intervention in the setting of adhesive bowel obstruction has been recently shown to increase the rate of surgical site infection (SSI), raising the concern for bacterial translocation. The effect of obstruction on SSI rate in patients with ventral hernia is unknown. The aim of this study was to assess the association between bowel obstruction and SSI in patients undergoing ventral hernia repair (VHR).

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Materials and Methods: This study is a retrospective database review. Patients undergoing isolated VHR from 2005 to 2011 were identified from the ACS-NSQIP database. Demographics, co-morbidities, and 30-day outcomes were analyzed. Multivariate logistic regression was used for

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variables with p-value