"
that the second one would also have died but The dose of poison having for the antidote. "consequently been proved sufficient to be "
"
certainly deadly."
Aron administered the
venom by hypodermic injection : bleaching powder in aqueous solution being used as the antidote in a similar The following experiments are demanner.
scribed
by
Aron.
Experiment NOTES ON CHLORINE AS AN ANTIDOTE FOR COBRA VENOM. By
the
late Vincent Richards,
f.r.c.s.e., Warden, f.r.c.s.e.
~v
and
C. J. H.
38.
One gramme of old chloride of lime
sus-
c.c.
The animal' used for
injection
of the
by Warden. weighed 680 grams. Shortly before leaving Berlin in 1885, A. Professor Dr. Robert Koch gave me a paper by 1-5 p.m.?Subcutaneously injected Tlieodor Aron,* on certain with Introductory
was
of water, and the mixture pended filtered through glass-wool. The solution contained about 1 per cent, of available chlorine. in 20
Note
poison
with f005 venom : and at the same time, close to gram, snake venom, and the site of the venom injection, with 1 c.c. of repeat those in which chlorine had been used the bleaching powder solution. as an antidote. On my return to Calcutta I 1-50 p.m.?No change. accidentally made Vincent Richard's acquaintance at a theatre : our conversation soon drifted 1-55 P.M.?Jumps about. to the 2 to 6 p.m.?No change. subject nearest Richards' heart?snakes. Arrangements were made for instituting a The control test animal weighed 700 grams. series of experiments on the action of various B. reagents on cobra venom, and a few experiments were performed which are detailed in Injected with *005 gram, venom. this note. Our investigations were, then interThe eye-lids semi-open. LameAffected. rupted, and before they could be resumed ness; drags itself with difficulty; at intervals Richards died. spasmodic convulsion?, which very soon become Before detailing our experiments a brief frequenter and.stronger. resume of the results arrived at by Aron, with 2-5 pm.?Tries to breathe under violent conchlorine as an antidote, will be necessary. vulsions. Aron, in the paper already quoted, refers to 2-8 p.m.?Dies. the employment as antidotes, of alcohol, atropine, caffeine, ozone, potassium permanganate and chlorine. In connection with the use of chloIn the next experiment rabbits of the same rine Aron remarks "By the exceedingly satis- litter were used. " factory results arrived at by Lenz from the " Experiment 39. use of chlorine as an antidote against the bite " of the common adder, I was encouraged to A. " utilize chlorine as an antidote against the 680 grams. Weight, " poison of the spectacle snake? Brillen 4-40 P.M.?Injected with *005 gram, venom in " schlange. Experiments which I made in this a I per cent, solution ; and immediately afterTo wards with 1 c.c. of the same "direction have confirmed my opinion. bleaching powder " the that animal the objection solution used in the first experiment, the injecguard against " experimented upon might perhaps have lived tion being made in the immediate neighbourhood " also without the administration of an antidote, of the venom injection. " 1 used two animals for each experiment, 5-40 to 6-40 p.m.?Unaffected. "generally of the same litter, and similar in " B. colour, reserving the heavier and stronger as " the poison test, and which only received the Weight, 780 grams. " venom, while the lighter and weaker one Injected with '005 gram, venom. "received both the poison and antidote. If 5-30 p.m. Stretched out; head drooping. " the first one died, it might safely be assumed
experiments suggested that I should
?
* *
Experimentille studien
Pharmakologischen
iiber
Institub
Theodor Aron, Cand. Med.
Schlangengift. (Aus
der
universitat
Bonn)
dem von
not
In this
experiment the nature of the animal used is mentioned; it is simply mentioned a3 the " Versuchs-
tier."
200
INDIAN MEDICAL GAZETTE.
5-50 p.m.
Can be turned
resistance; convulsive
its side withou
breathing.
5-55 P.M.?Violent side. 5-57 p.m.?Dies.
convulsions;
falls
on
its
1-20 p.m.?No change apparent. 1-30 P.M.?Normal. 1-33 p.m.?No symptoms.
litter.
same
1-35
A?
1-50
830 grams.
Weight, 12-5 p.m.?Injected
*005 gram, of with venom in a 1 per cent, solution and then with 1 c.c. of the bleaching powder solution, close to the site of the first injection. 12-25 P.M.?Normal condition. 12-35 p.m.?Normal condition. and un12-42 p.m.?Appears quite lively affected. 1-10 p.m.? Able to move about, but the head is drooping ; ears drawn ; sitting longwise, and when turned on its side does not rise of its own accord. 1-20 P.M.?Breathing slow and difficult. 1-25
convulsions. 2-5 p.m.?Breathing very slow and violent con vulsious soon follow. 2-10 p.m.?Dies.
Weight, 910 grams. Injected with ?005 gram,
venom
in
cent, solution.
a
1 per
Stretched out; ears hanging down; eye-lids only partly open; head sinks: when placed on its side, remains in that position. Lameness nearly complete; respiratory movements extremely feeble. with violent
convul-
sions, and dies.
Commenting on the results of this experiment Aron remarks : " In this instance the chlorine " was not able to save the animal's life ; never" theless its application had a visible effect " inasmuch as A died nearly an hour after B, " although the latter was the stronger and et I was unable to find out heavier animal.
that the second one would also have died but The dose of poison having for the antidote. "consequently been proved sufficient to be "
"
certainly deadly."
Aron administered the
venom by hypodermic injection : bleaching powder in aqueous solution being used as the antidote in a similar The following experiments are demanner.
scribed
by
Aron.
Experiment NOTES ON CHLORINE AS AN ANTIDOTE FOR COBRA VENOM. By
the
late Vincent Richards,
f.r.c.s.e., Warden, f.r.c.s.e.
~v
and
C. J. H.
38.
One gramme of old chloride of lime
sus-
c.c.
The animal' used for
injection
of the
by Warden. weighed 680 grams. Shortly before leaving Berlin in 1885, A. Professor Dr. Robert Koch gave me a paper by 1-5 p.m.?Subcutaneously injected Tlieodor Aron,* on certain with Introductory
was
of water, and the mixture pended filtered through glass-wool. The solution contained about 1 per cent, of available chlorine. in 20
Note
poison
with f005 venom : and at the same time, close to gram, snake venom, and the site of the venom injection, with 1 c.c. of repeat those in which chlorine had been used the bleaching powder solution. as an antidote. On my return to Calcutta I 1-50 p.m.?No change. accidentally made Vincent Richard's acquaintance at a theatre : our conversation soon drifted 1-55 P.M.?Jumps about. to the 2 to 6 p.m.?No change. subject nearest Richards' heart?snakes. Arrangements were made for instituting a The control test animal weighed 700 grams. series of experiments on the action of various B. reagents on cobra venom, and a few experiments were performed which are detailed in Injected with *005 gram, venom. this note. Our investigations were, then interThe eye-lids semi-open. LameAffected. rupted, and before they could be resumed ness; drags itself with difficulty; at intervals Richards died. spasmodic convulsion?, which very soon become Before detailing our experiments a brief frequenter and.stronger. resume of the results arrived at by Aron, with 2-5 pm.?Tries to breathe under violent conchlorine as an antidote, will be necessary. vulsions. Aron, in the paper already quoted, refers to 2-8 p.m.?Dies. the employment as antidotes, of alcohol, atropine, caffeine, ozone, potassium permanganate and chlorine. In connection with the use of chloIn the next experiment rabbits of the same rine Aron remarks "By the exceedingly satis- litter were used. " factory results arrived at by Lenz from the " Experiment 39. use of chlorine as an antidote against the bite " of the common adder, I was encouraged to A. " utilize chlorine as an antidote against the 680 grams. Weight, " poison of the spectacle snake? Brillen 4-40 P.M.?Injected with *005 gram, venom in " schlange. Experiments which I made in this a I per cent, solution ; and immediately afterTo wards with 1 c.c. of the same "direction have confirmed my opinion. bleaching powder " the that animal the objection solution used in the first experiment, the injecguard against " experimented upon might perhaps have lived tion being made in the immediate neighbourhood " also without the administration of an antidote, of the venom injection. " 1 used two animals for each experiment, 5-40 to 6-40 p.m.?Unaffected. "generally of the same litter, and similar in " B. colour, reserving the heavier and stronger as " the poison test, and which only received the Weight, 780 grams. " venom, while the lighter and weaker one Injected with '005 gram, venom. "received both the poison and antidote. If 5-30 p.m. Stretched out; head drooping. " the first one died, it might safely be assumed
experiments suggested that I should
?
* *
Experimentille studien
Pharmakologischen
iiber
Institub
Theodor Aron, Cand. Med.
Schlangengift. (Aus
der
universitat
Bonn)
dem von
not
In this
experiment the nature of the animal used is mentioned; it is simply mentioned a3 the " Versuchs-
tier."
200
INDIAN MEDICAL GAZETTE.
5-50 p.m.
Can be turned
resistance; convulsive
its side withou
breathing.
5-55 P.M.?Violent side. 5-57 p.m.?Dies.
convulsions;
falls
on
its
1-20 p.m.?No change apparent. 1-30 P.M.?Normal. 1-33 p.m.?No symptoms.
litter.
same
1-35
A?
1-50
830 grams.
Weight, 12-5 p.m.?Injected
*005 gram, of with venom in a 1 per cent, solution and then with 1 c.c. of the bleaching powder solution, close to the site of the first injection. 12-25 P.M.?Normal condition. 12-35 p.m.?Normal condition. and un12-42 p.m.?Appears quite lively affected. 1-10 p.m.? Able to move about, but the head is drooping ; ears drawn ; sitting longwise, and when turned on its side does not rise of its own accord. 1-20 P.M.?Breathing slow and difficult. 1-25
convulsions. 2-5 p.m.?Breathing very slow and violent con vulsious soon follow. 2-10 p.m.?Dies.
Weight, 910 grams. Injected with ?005 gram,
venom
in
cent, solution.
a
1 per
Stretched out; ears hanging down; eye-lids only partly open; head sinks: when placed on its side, remains in that position. Lameness nearly complete; respiratory movements extremely feeble. with violent
convul-
sions, and dies.
Commenting on the results of this experiment Aron remarks : " In this instance the chlorine " was not able to save the animal's life ; never" theless its application had a visible effect " inasmuch as A died nearly an hour after B, " although the latter was the stronger and et I was unable to find out heavier animal.
