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Stroke. Author manuscript; available in PMC 2017 October 01. Published in final edited form as: Stroke. 2016 October ; 47(10): 2511–2516. doi:10.1161/STROKEAHA.116.014425.

Non-contrast CT hypodensities Predict Poor Outcome in Intracerebral Hemorrhage Patients

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Gregoire Boulouis, MD, MSc1, Andrea Morotti, MD1, H. Bart Brouwers, MD, PhD1,2, Andreas Charidimou, MD, PhD1, Michael J. Jessel, BS1, Eitan Auriel, MD, PhD1, Octavio PontesNeto, MD, PhD1,3, Alison Ayres, BA1, Anastasia Vashkevich, BA1, Kristin M. Schwab, BA1, Jonathan Rosand, MD, MSc1,4, Anand Viswanathan, MD-PhD1, Mahmut E. Gurol, MD-MSc1, Steven M. Greenberg, MD, PhD1, and Joshua N. Goldstein, MD, PhD1,4,5 1Hemorrhagic

Stroke Research Program, Department of Neurology, Massachusetts General Hospital Stroke Research Center, Harvard Medical School, Boston, MA, USA 2Department of Neurosurgery, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands 3Stroke Service, Department of Neuroscience and Behavioral Sciences, Ribeirao Preto School of Medicine, University of Sao Paulo. 4Division of Neurocritical Care and Emergency Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. 5Department of Emergency Medicine, Massachusetts General Hospital, Boston, MA, USA.

Abstract Author Manuscript

Background and Purpose—Noncontrast CT hypodensities have been shown to be associated with hematoma expansion in intracerebral hemorrhage (ICH), but their impact on functional outcome is yet to be determined. We evaluated whether baseline noncontrast CT hypodensities are associated with poor clinical outcome. Methods—We performed a retrospective review of a prospectively collected cohort of consecutive patients with primary ICH presenting to a single academic medical center

Corresponding Author: Gregoire Boulouis, Stroke Research Center, 175 Cambridge Street, suite 300, Boston MA 02114, Phone +1 617 991 0816 - Fax +1 617 643 3939, [email protected]. Potential conflict of interest Dr. Goldstein has received consulting and research from CSL Behring, and Boehringer Ingelheim.

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Financial disclosures G. Boulouis: None A. Morotti: None H. Bart Brouwers: None A. Charidimou: None Michael J. Jessel: None E. Auriel: None Octavio Pontes-Neto: None A. Ayres: None A. Vashkevich: None K. M. Schwab: None J. Rosand: None Anand Viswanathan: None M. E. Gurol: None S. M. Greenberg: None J.N. Goldstein: None

Boulouis et al.

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between1994 and 2016. The presence of CT hypodensities was assessed by two independent raters on the baseline CT. Unfavorable outcome was defined as a modified Rankin score >3 at 90 days. The associations between CT hypodensities and unfavorable outcome were investigated using uniand multivariable logistic regression models. Results—During the study period 1342 patients presented with ICH, and 800 met restrictive inclusion criteria (baseline CT available for review, and 90 day outcome available). 304 (38%) showed hypodensities on CT, and 520 (65%) experienced unfavorable outcome. In univariate analysis, patients with unfavorable outcome were more likely to demonstrate hypodensities (48% vs 20%, p

Noncontrast Computed Tomography Hypodensities Predict Poor Outcome in Intracerebral Hemorrhage Patients.

Noncontrast computed tomographic (CT) hypodensities have been shown to be associated with hematoma expansion in intracerebral hemorrhage (ICH), but th...
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