Tissue Antigens ISSN 0001-2815
NOMENCLATURE UPDATE
Nomenclature for factors of the HLA system, update February 2015
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System. Correspondence Professor Steven G. E. Marsh, Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, London NW3 2QG, United Kingdom. Tel: +44 20 7284–8321; Fax: +44 20 7284–8331; email: [email protected]; URLs: hla.alleles.org; www.anthonynolan.org/hig; www.ebi.ac.uk/ipd/imgt/hla doi: 10.1111/tan.12577
The following sequences have been submitted to the Nomenclature Committee since the January 2015 nomenclature update and, following agreed policy, have been assigned official allele designations (1). Full details of all sequences will be published in a forthcoming report. Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such
a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. The sequence A*26:03:02 was shown to have been named in error and has been renamed as A*26:111. The name A*26:03:02 has been abandoned. All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the World Wide Web at: www.ebi.ac.uk/ipd/imgt/hla
Table 1 New Sequences HLA Allele
Cell identification
Accession number
Submitting author
A*01:176 A*01:177 A*02:01:116 A*02:01:117 A*02:01:118 A*02:02:03 A*02:06:19 A*02:07:08 A*02:560 A*02:561 A*02:562 A*02:563 A*02:564 A*02:565 A*02:566 A*02:567 A*02:568 A*02:569 A*02:570 A*02:571 A*02:572 A*02:573 A*03:219 A*03:220
shanxi031 shanxi054 HG00009553 HG00009554 HG00009559 HG00009563 shanxi044 T102 HG00009552 HG00009555 HG00009556 HG00009557 HG00009558 HG00009560 HG00009561 HG00009562 HG00009564 HG00009565 368104 shanxi061 5030215 M-360736 HG00009540 shanxi024
KP693406 KP716815 KP279709 KM987149 KP163932 KP192426 KP716805 KP404443 KP192424 KP192428 KM670530 KM987191 KM987145 KP163933 KM987190 KM987192 KP163930 KP192429 LN795904 KP716822 KP774530 KP768458 KM987184 KP693399
Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Demei Zhang, Taiyuan, China Wei Tian, Changsha, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Edward KL Yang, Hualien, Taiwan Demei Zhang, Taiyuan, China Antonio Balas, Madrid, Spain Kristin Kipper, Martinsried, Germany Histogenetics, Ossining, USA Demei Zhang, Taiyuan, China
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd ⋅ Tissue Antigens, 2015, 86, 43–47 The World Health Organization retains copyright and all other rights in the manuscript of this article as submitted for publication.
43
S. G. E. Marsh
Nomenclature for factors of the HLA system, update February 2015
Table 1 Continued HLA Allele
Cell identification
Accession number
Submitting author
A*03:221 A*11:01:67 A*24:02:93 A*24:02:94 A*24:172:02 A*24:304 A*25:01:09 A*26:111 A*26:112 A*30:95 A*31:95 A*32:72 A*33:97 A*68:119:02 B*07:248 B*07:249 B*07:250 B*07:251N B*13:01:11 B*15:11:07 B*15:348 B*15:349 B*15:350 B*15:351 B*15:352 B*15:353 B*27:04:05 B*27:05:31 B*35:283 B*35:284 B*39:103 B*40:01:42 B*40:300 B*40:301 B*40:302 B*41:01:04 B*52:01:25 B*52:01:26 B*52:01:27 B*52:45 B*52:46 B*55:72 B*58:70 B*58:71 C*01:108 C*02:96 C*02:97 C*02:98 C*02:99 C*02:100 C*03:279 C*03:280 C*03:281 C*05:115 C*05:116 C*06:70:02 C*07:417 C*07:418 C*07:419 C*08:01:19 C*08:117
M-379127 shanxi047 shanxi043 shanxi055 shanxi046 shanxi053 HG00000090 JMDP01K090 shanxi037 shanxi018 shanxi028 M-352644 ZJCB20140914006 shanxi040 shanxi22, shanxi068 333765 shanxi052 M-184744 shanxi030 shanxi057 shanxi019 shanxi041 shanxi049 shanxi050 shanxi066 M-145230 shanxi051 RMC27381 shanxi023 shanxi026 shanxi029 shanxi048 shanxi014 SMC201410 BWU01 shanxi071 shanxi033 shanxi039 5801300025 JRC-D01-170 shanxi058 shanxi025 shanxi056 shanxi059 shanxi032 HG00009662 HG00009663 HG00009664 HG00009665 HG00009666 EVANIG SMC201406 shanxi065 HG00009646 HG00009651 shanxi069 HG00009641 HG00009642 MAWI795220 HG00009650 HG00009649
KP768447 KP716808 KP716804 KP716816 KP716807 KP716814 HQ226103 AB540607 KP693412 KP693392 KP693403 KP768448 KP728939 KP716801 KP693397, KP716830 LN795906 KP716813 KP294307 KP693405 KP716818 KP693393 KP716803 KP716810 KP716811 KP716828 KP768449 KP716812 LN810554 KP693398 KP693401 KP693404 KP716809 KP693389 KP705145 KP723551 KP716829 KP693408 KP716800 KP728940 AB971355 KP716819 KP693400 KP716817 KP716820 KP693407 KP057110 KP192451 KP310886 KP310883 KP192446 LN794633 KP705144 KP716826 KM987202 KP256326 KP716827 KP057114 KP131488 LN795900 KP192449 KP057109
Kristin Kipper, Martinsried, Germany Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Kenji Tadokoro, Tokyo, Japan Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Kristin Kipper, Martinsried, Germany Faming Zhu, Hangzhou, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Edward KL Yang, Hualien, Taiwan Demei Zhang, Taiyuan, China Kristin Kipper, Martinsried, Germany Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Kristin Kipper, Martinsried, Germany Demei Zhang, Taiyuan, China Maria Loginova, Kirov, Russia Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Oh-Joong Kwon, Seoul, South Korea Oh-Joong Kwon, Seoul, South Korea Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Faming Zhu, Hangzhou, China Kenji Tadokoro, Tokyo, Japan Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Paul Dunn, Leicester, United Kingdom Oh-Joong Kwon, Seoul, South Korea Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Steven GE Marsh, London, United Kingdom Histogenetics, Ossining, USA Histogenetics, Ossining, USA
44
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd ⋅ Tissue Antigens, 2015, 86, 43–47 The World Health Organization retains copyright and all other rights in the manuscript of this article as submitted for publication.
S. G. E. Marsh
Nomenclature for factors of the HLA system, update February 2015
Table 1 Continued HLA Allele
Cell identification
Accession number
Submitting author
C*08:118 C*12:03:35 C*12:150 C*12:151 C*12:152 C*14:70 C*15:04:02 C*15:107 C*15:108 C*15:109 C*16:81 C*16:82 C*16:83 C*17:29 DRB1*03:119 DRB1*04:06:06 DRB1*04:11:04 DRB1*04:131:02 DRB1*04:187 DRB1*04:188 DRB1*07:01:09 DRB1*07:01:10 DRB1*07:01:11 DRB1*07:01:12 DRB1*07:01:13 DRB1*07:01:14 DRB1*07:01:15 DRB1*07:01:16 DRB1*07:36 DRB1*07:37 DRB1*07:38 DRB1*07:39
shanxi035 HG00009653, HG00009654 HG00009658 HG00009659 HG00009660 shanxi064 HG00009668, HG00009669 HG00009645 HG00009667 HG00009670 HG00009655 HG00009656 HG00009657 HG00009661 shanxi020 shanxi063 HG00009755 HG00009756 HG00009754 HG00009757 HG00009382 HG00009392 HG00009394 HG00009395 HG00009397 HG00009401 HG00009415 HG00009748 HG00009379 HG00009380 HG00009381 HG00009383, HG00009384,HG00009385, HG00009386 HG00009393 HG00009396 HG00009403, HG00009404 HN-60278-8 HG00009405, HG00009406, HG00009407, HG00009408 HG00009409 HG00009422, HG00009423 HG00009424 HG00009425, HG00009426, HG00009427 HG00009428 HG00009429 HG00009430, HG00009431, HG00009432 HG00009433 HG00009742 HG00009743 HG00009744 HG00009745 HG00009746 HG00009747 CTM 0025844 376806 HG00009749 shanxi027 shanxi045, shanxi062
KP693410 KP163950, KP131494 KP310893 KM987206 KP192445 KP716825 KP163952, KP163951 KP256327 KP227738 KM604673 KP131498 KP310889 KP279715 KP310888 KP693395 KP716824 KP192461 KM987221 KM987219 KM987218 KM455037 KM586215 KM455009 KM455038 KM455008 KM455033 KM455017 KP163964 KM455004 KM455041 KM455010 KM455028, KM455029, KM455039, KM586207
Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA
KM455011 KM455006 KM455022, KM455023 KM586195 KM455024, KM455012, KM455013, KM455026 KM455036 KM586211, KM455043 KM455046 KM455047, KM455018, KM455035
Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA
KM586202 KM455007 KM455048, KM455045, KM586209
Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA
KM455014 KM604682 KM604691 KM604683 KP256334 KM670552 KM604680 KP693696 LN795907 KM604686 KP693402 KP716806, KP716823
Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Antonio Balas, Madrid, Spain Edward KL Yang, Hualien, Taiwan Histogenetics, Ossining, USA Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China
DRB1*07:40 DRB1*07:41 DRB1*07:42 DRB1*07:43 DRB1*07:44 DRB1*07:45 DRB1*07:46 DRB1*07:47 DRB1*07:48 DRB1*07:49 DRB1*07:50 DRB1*07:51 DRB1*07:52 DRB1*07:53 DRB1*07:54 DRB1*07:55 DRB1*07:56 DRB1*07:57 DRB1*07:58N DRB1*08:70 DRB1*08:71 DRB1*09:01:11 DRB1*09:25 DRB1*11:29:02
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd ⋅ Tissue Antigens, 2015, 86, 43–47 The World Health Organization retains copyright and all other rights in the manuscript of this article as submitted for publication.
45
S. G. E. Marsh
Nomenclature for factors of the HLA system, update February 2015
Table 1 Continued HLA Allele
Cell identification
Accession number
Submitting author
DRB1*11:177 DRB1*13:199 DRB1*13:200N DRB1*14:161 DRB1*15:118 DRB1*15:119 DRB1*15:120 DRB1*15:121 DRB1*16:01:07 DRB1*16:01:08 DRB1*16:30 DRB1*16:31 DRB1*16:32 DRB1*16:33 DRB1*16:34 DRB3*01:16 DQB1*02:01:20 DQB1*02:01:21 DQB1*02:01:22 DQB1*02:01:23 DQB1*02:54
shanxi038 HG00009753 HG00007919 shanxi060 HG00009732, HG00009733 HG00009739 HG00009740 shanxi015 HG00009735, HG00009736 HG00009737 HG00009731 HG00009734 HG00009738 HG00009741 M-543109 IME 2230–14, IME 2231-14 HG00009697 HG00009701 HG00009703 HG00009719 HG00009698, HG00009699, HG00009700 HG00009702 HG00009704 HCV151 140917029 HG00009695 HG00009716 HG00009718 HG00009691 HG00009692 HG00009693 HG00009694 HG00009696 HG00009712 HG00009713 HG00009714, HG00009715 HG00009717 M-427700 HG00009726 HG00009724 HG00009725 HG00009720 HG00009723 shanxi034 HG00009721 HG00009722 HG00009727 HG00009708 HG00009690 HG00009705 HG00009706, HG00009707 HG00009709, HG00009710 HG00009711 HG00009729 HG00009730 M-505196 1Rom
KP693413 KP163967 KF925413 KP716821 KP057133, KP192466 KP163962 KP057129 KP693394 KM987165, KM987166 KP227744 KM987168 KM987167 KP057132 KP057131 KP768452 KP784418 KM604679 KP310901 KP279725 KP057128 KP057123, KP227742, KP279724 KP057122 KP192460 KP743137 LN810062 KM987163 KM604676 KP131460 KP227740 KP131462 KM987161 KP057126 KP310902 KM987215 KP192457 KM987217, KM987164 KP279726 KP768453 KP192456 KP192458 KP310900 KP279721 KP131459 KP693409 KP057121 KP310896 KM987159 KM987212 KP256330 KP256331 KM987160, KP163956 KP279723, KP279722 KP279720 KP310898 KP057119 KP768455 KP262025
Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Kristin Kipper, Martinsried, Germany Manuela Testi, Rome, Italy Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA
DQB1*02:55 DQB1*02:56 DQB1*02:57 DQB1*02:58N DQB1*03:01:29 DQB1*03:02:18 DQB1*03:02:19 DQB1*03:170 DQB1*03:171 DQB1*03:172 DQB1*03:173 DQB1*03:174 DQB1*03:175 DQB1*03:176 DQB1*03:177 DQB1*03:178 DQB1*03:179 DQB1*04:02:09 DQB1*04:28 DQB1*04:29 DQB1*05:01:20 DQB1*05:02:13 DQB1*05:03:17 DQB1*05:91 DQB1*05:92 DQB1*06:02:24 DQB1*06:03:19 DQB1*06:168 DQB1*06:169 DQB1*06:170 DQB1*06:171 DQB1*06:172 DQB1*06:173 DQB1*06:174 DQB1*06:175 MICA*085
46
Histogenetics, Ossining, USA Histogenetics, Ossining, USA Faming Zhu, Hangzhou, China Vicky Van Sandt, Mechelen, Belgium Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Kristin Kipper, Martinsried, Germany Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Kristin Kipper, Martinsried, Germany Daniel Fuerst, Ulm, Germany
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd ⋅ Tissue Antigens, 2015, 86, 43–47 The World Health Organization retains copyright and all other rights in the manuscript of this article as submitted for publication.
S. G. E. Marsh
Nomenclature for factors of the HLA system, update February 2015
Table 2 Confirmatory Sequences HLA Allele
Cell identification
Accession number
Submitting author
A*02:01:102 A*02:436 A*11:183 A*24:02:61 A*24:225:01 A*24:287 A*26:74 A*66:22 B*15:347 B*40:249 B*58:59 C*02:06 C*07:374 C*08:95 DRB1*07:01:08
HG00009566 6311100459 HN-013007 6311100156 5351100055 386135 HN-75759-0 MG98070813 shanxi021, shanxi067 shanxi016 shanxi017 10201, 50452 shanxi036 HG00009652 HG00009410, HG00009411, HG00009412, HG00009413, HG00009414 HG00009416, HG00009417, HG00009418, HG00009419, HG00009420, HG00009421 HG00009387, HG00009388, HG00009389, HG00009390, HG00009391 HG00009398, HG00009399, HG00009400 HG00009750, HG00009751, HG00009752
KP310875 1727830 HQ226081 1726223 1726168 LN795905 HQ226095 KP262055 KP693396, KP716829 KP693390 KP693391 KP765600 KP693411 KM987205 KM455030, KM455027, KM455015, KM455016, KM455025 KM455032, KM455019, KM455020, KM455021, KM586201, KM586198
Histogenetics, Ossining, USA Zhanhui Du, Qingdao, China Histogenetics, Ossining, USA Zhanhui Du, Qingdao, China Zhi-Hui Feng, Qingdao, China Edward KL Yang, Hualien, Taiwan Histogenetics, Ossining, USA Susana G Marino, Chicago, USA Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Runying Tian, Durham, USA Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA
KM455044, KM586208, KM586205, KM455040, KM455042 KM455031, KM455034, KM586203 KM604685, KM604684, KM604687
Histogenetics, Ossining, USA
DRB1*07:29
DRB1*07:30 DRB1*07:32 DRB1*09:23
Table 3 Recently Published Sequences HLA Allele A*01:123N A*23:19N B*27:105 B*35:231 B*41:21 B*53:31 C*07:294 DRB1*12:51 DQA1*01:12 DQB1*02:10 DQB1*03:03:02:04 DPB1*363:01
References (3) (4) (5) (3) (3) (3) (3) (6) (3) (3) (7) (8)
Conflict of interest
The author declares no conflict of interest. References: 1. Marsh SGE, Albert ED, Bodmer WF et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens 2010: 75: 291–455.
Histogenetics, Ossining, USA
Histogenetics, Ossining, USA Histogenetics, Ossining, USA
2. Robinson J, Halliwell JA, McWilliam H, Lopez R, Parham P, Marsh SGE. The IMGT/HLA database. Nucleic Acids Res 2013: 41: D1222–7. 3. Adamek M, Klages C, Bauer M et al. Seven novel HLA alleles reflect different mechanisms involved in the evolution of HLA diversity: description of the new alleles and review of the literature. Hum Immunol 2015: 76: 30–5. 4. Gerritsen KE, Voorter CE, Joannes MO et al. RNA and protein expression of HLA-A( *)23:19Q. Hum Immunol 2015: 76: 286–91. 5. He J, He YM, Zhang W, Wang W, Zhu FM, Lv HJ. Identification a novel HLA-B*27:105 allele in a Chinese bone marrow donor by polymerase chain reaction sequence-based typing. Tissue Antigens 2015: 85: 212–3. 6. Li Y, Tang XW, Wu JY, Huang YN, Liao C. Identification of a novel HLA-DRB1 allele, HLA-DRB1*12:51, in a Chinese Cord Blood Donor. Tissue Antigens 2015: 85: 216–7. 7. Cervera I, Herraiz MA, Vidart J, Ortega S, Martinez-Laso J. Identification of the novel HLA-DQB1*03:03:02:04 allele in a Spanish individual. Tissue Antigens 2015: 85: 215–6. 8. Wang C, Wang J, Ou G, Ji X, Liu Z, Chen Q. The new allele HLA-DPB1*363:01 identified by sequence-based typing in a donor from the Chinese Marrow Donor Program. Tissue Antigens 2015: 85: 213–5.
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd ⋅ Tissue Antigens, 2015, 86, 43–47 The World Health Organization retains copyright and all other rights in the manuscript of this article as submitted for publication.
47
NOMENCLATURE UPDATE
Nomenclature for factors of the HLA system, update February 2015
Compiled by Steven G. E. Marsh for the WHO Nomenclature Committee for Factors of the HLA System. Correspondence Professor Steven G. E. Marsh, Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, London NW3 2QG, United Kingdom. Tel: +44 20 7284–8321; Fax: +44 20 7284–8331; email: [email protected]; URLs: hla.alleles.org; www.anthonynolan.org/hig; www.ebi.ac.uk/ipd/imgt/hla doi: 10.1111/tan.12577
The following sequences have been submitted to the Nomenclature Committee since the January 2015 nomenclature update and, following agreed policy, have been assigned official allele designations (1). Full details of all sequences will be published in a forthcoming report. Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such
a case you will have to contact the submitting author directly. Additional information pertaining to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. The sequence A*26:03:02 was shown to have been named in error and has been renamed as A*26:111. The name A*26:03:02 has been abandoned. All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided (2). The IMGT/HLA Database may be accessed via the World Wide Web at: www.ebi.ac.uk/ipd/imgt/hla
Table 1 New Sequences HLA Allele
Cell identification
Accession number
Submitting author
A*01:176 A*01:177 A*02:01:116 A*02:01:117 A*02:01:118 A*02:02:03 A*02:06:19 A*02:07:08 A*02:560 A*02:561 A*02:562 A*02:563 A*02:564 A*02:565 A*02:566 A*02:567 A*02:568 A*02:569 A*02:570 A*02:571 A*02:572 A*02:573 A*03:219 A*03:220
shanxi031 shanxi054 HG00009553 HG00009554 HG00009559 HG00009563 shanxi044 T102 HG00009552 HG00009555 HG00009556 HG00009557 HG00009558 HG00009560 HG00009561 HG00009562 HG00009564 HG00009565 368104 shanxi061 5030215 M-360736 HG00009540 shanxi024
KP693406 KP716815 KP279709 KM987149 KP163932 KP192426 KP716805 KP404443 KP192424 KP192428 KM670530 KM987191 KM987145 KP163933 KM987190 KM987192 KP163930 KP192429 LN795904 KP716822 KP774530 KP768458 KM987184 KP693399
Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Demei Zhang, Taiyuan, China Wei Tian, Changsha, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Edward KL Yang, Hualien, Taiwan Demei Zhang, Taiyuan, China Antonio Balas, Madrid, Spain Kristin Kipper, Martinsried, Germany Histogenetics, Ossining, USA Demei Zhang, Taiyuan, China
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd ⋅ Tissue Antigens, 2015, 86, 43–47 The World Health Organization retains copyright and all other rights in the manuscript of this article as submitted for publication.
43
S. G. E. Marsh
Nomenclature for factors of the HLA system, update February 2015
Table 1 Continued HLA Allele
Cell identification
Accession number
Submitting author
A*03:221 A*11:01:67 A*24:02:93 A*24:02:94 A*24:172:02 A*24:304 A*25:01:09 A*26:111 A*26:112 A*30:95 A*31:95 A*32:72 A*33:97 A*68:119:02 B*07:248 B*07:249 B*07:250 B*07:251N B*13:01:11 B*15:11:07 B*15:348 B*15:349 B*15:350 B*15:351 B*15:352 B*15:353 B*27:04:05 B*27:05:31 B*35:283 B*35:284 B*39:103 B*40:01:42 B*40:300 B*40:301 B*40:302 B*41:01:04 B*52:01:25 B*52:01:26 B*52:01:27 B*52:45 B*52:46 B*55:72 B*58:70 B*58:71 C*01:108 C*02:96 C*02:97 C*02:98 C*02:99 C*02:100 C*03:279 C*03:280 C*03:281 C*05:115 C*05:116 C*06:70:02 C*07:417 C*07:418 C*07:419 C*08:01:19 C*08:117
M-379127 shanxi047 shanxi043 shanxi055 shanxi046 shanxi053 HG00000090 JMDP01K090 shanxi037 shanxi018 shanxi028 M-352644 ZJCB20140914006 shanxi040 shanxi22, shanxi068 333765 shanxi052 M-184744 shanxi030 shanxi057 shanxi019 shanxi041 shanxi049 shanxi050 shanxi066 M-145230 shanxi051 RMC27381 shanxi023 shanxi026 shanxi029 shanxi048 shanxi014 SMC201410 BWU01 shanxi071 shanxi033 shanxi039 5801300025 JRC-D01-170 shanxi058 shanxi025 shanxi056 shanxi059 shanxi032 HG00009662 HG00009663 HG00009664 HG00009665 HG00009666 EVANIG SMC201406 shanxi065 HG00009646 HG00009651 shanxi069 HG00009641 HG00009642 MAWI795220 HG00009650 HG00009649
KP768447 KP716808 KP716804 KP716816 KP716807 KP716814 HQ226103 AB540607 KP693412 KP693392 KP693403 KP768448 KP728939 KP716801 KP693397, KP716830 LN795906 KP716813 KP294307 KP693405 KP716818 KP693393 KP716803 KP716810 KP716811 KP716828 KP768449 KP716812 LN810554 KP693398 KP693401 KP693404 KP716809 KP693389 KP705145 KP723551 KP716829 KP693408 KP716800 KP728940 AB971355 KP716819 KP693400 KP716817 KP716820 KP693407 KP057110 KP192451 KP310886 KP310883 KP192446 LN794633 KP705144 KP716826 KM987202 KP256326 KP716827 KP057114 KP131488 LN795900 KP192449 KP057109
Kristin Kipper, Martinsried, Germany Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Kenji Tadokoro, Tokyo, Japan Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Kristin Kipper, Martinsried, Germany Faming Zhu, Hangzhou, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Edward KL Yang, Hualien, Taiwan Demei Zhang, Taiyuan, China Kristin Kipper, Martinsried, Germany Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Kristin Kipper, Martinsried, Germany Demei Zhang, Taiyuan, China Maria Loginova, Kirov, Russia Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Oh-Joong Kwon, Seoul, South Korea Oh-Joong Kwon, Seoul, South Korea Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Faming Zhu, Hangzhou, China Kenji Tadokoro, Tokyo, Japan Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Paul Dunn, Leicester, United Kingdom Oh-Joong Kwon, Seoul, South Korea Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Steven GE Marsh, London, United Kingdom Histogenetics, Ossining, USA Histogenetics, Ossining, USA
44
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd ⋅ Tissue Antigens, 2015, 86, 43–47 The World Health Organization retains copyright and all other rights in the manuscript of this article as submitted for publication.
S. G. E. Marsh
Nomenclature for factors of the HLA system, update February 2015
Table 1 Continued HLA Allele
Cell identification
Accession number
Submitting author
C*08:118 C*12:03:35 C*12:150 C*12:151 C*12:152 C*14:70 C*15:04:02 C*15:107 C*15:108 C*15:109 C*16:81 C*16:82 C*16:83 C*17:29 DRB1*03:119 DRB1*04:06:06 DRB1*04:11:04 DRB1*04:131:02 DRB1*04:187 DRB1*04:188 DRB1*07:01:09 DRB1*07:01:10 DRB1*07:01:11 DRB1*07:01:12 DRB1*07:01:13 DRB1*07:01:14 DRB1*07:01:15 DRB1*07:01:16 DRB1*07:36 DRB1*07:37 DRB1*07:38 DRB1*07:39
shanxi035 HG00009653, HG00009654 HG00009658 HG00009659 HG00009660 shanxi064 HG00009668, HG00009669 HG00009645 HG00009667 HG00009670 HG00009655 HG00009656 HG00009657 HG00009661 shanxi020 shanxi063 HG00009755 HG00009756 HG00009754 HG00009757 HG00009382 HG00009392 HG00009394 HG00009395 HG00009397 HG00009401 HG00009415 HG00009748 HG00009379 HG00009380 HG00009381 HG00009383, HG00009384,HG00009385, HG00009386 HG00009393 HG00009396 HG00009403, HG00009404 HN-60278-8 HG00009405, HG00009406, HG00009407, HG00009408 HG00009409 HG00009422, HG00009423 HG00009424 HG00009425, HG00009426, HG00009427 HG00009428 HG00009429 HG00009430, HG00009431, HG00009432 HG00009433 HG00009742 HG00009743 HG00009744 HG00009745 HG00009746 HG00009747 CTM 0025844 376806 HG00009749 shanxi027 shanxi045, shanxi062
KP693410 KP163950, KP131494 KP310893 KM987206 KP192445 KP716825 KP163952, KP163951 KP256327 KP227738 KM604673 KP131498 KP310889 KP279715 KP310888 KP693395 KP716824 KP192461 KM987221 KM987219 KM987218 KM455037 KM586215 KM455009 KM455038 KM455008 KM455033 KM455017 KP163964 KM455004 KM455041 KM455010 KM455028, KM455029, KM455039, KM586207
Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA
KM455011 KM455006 KM455022, KM455023 KM586195 KM455024, KM455012, KM455013, KM455026 KM455036 KM586211, KM455043 KM455046 KM455047, KM455018, KM455035
Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA
KM586202 KM455007 KM455048, KM455045, KM586209
Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA
KM455014 KM604682 KM604691 KM604683 KP256334 KM670552 KM604680 KP693696 LN795907 KM604686 KP693402 KP716806, KP716823
Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Antonio Balas, Madrid, Spain Edward KL Yang, Hualien, Taiwan Histogenetics, Ossining, USA Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China
DRB1*07:40 DRB1*07:41 DRB1*07:42 DRB1*07:43 DRB1*07:44 DRB1*07:45 DRB1*07:46 DRB1*07:47 DRB1*07:48 DRB1*07:49 DRB1*07:50 DRB1*07:51 DRB1*07:52 DRB1*07:53 DRB1*07:54 DRB1*07:55 DRB1*07:56 DRB1*07:57 DRB1*07:58N DRB1*08:70 DRB1*08:71 DRB1*09:01:11 DRB1*09:25 DRB1*11:29:02
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd ⋅ Tissue Antigens, 2015, 86, 43–47 The World Health Organization retains copyright and all other rights in the manuscript of this article as submitted for publication.
45
S. G. E. Marsh
Nomenclature for factors of the HLA system, update February 2015
Table 1 Continued HLA Allele
Cell identification
Accession number
Submitting author
DRB1*11:177 DRB1*13:199 DRB1*13:200N DRB1*14:161 DRB1*15:118 DRB1*15:119 DRB1*15:120 DRB1*15:121 DRB1*16:01:07 DRB1*16:01:08 DRB1*16:30 DRB1*16:31 DRB1*16:32 DRB1*16:33 DRB1*16:34 DRB3*01:16 DQB1*02:01:20 DQB1*02:01:21 DQB1*02:01:22 DQB1*02:01:23 DQB1*02:54
shanxi038 HG00009753 HG00007919 shanxi060 HG00009732, HG00009733 HG00009739 HG00009740 shanxi015 HG00009735, HG00009736 HG00009737 HG00009731 HG00009734 HG00009738 HG00009741 M-543109 IME 2230–14, IME 2231-14 HG00009697 HG00009701 HG00009703 HG00009719 HG00009698, HG00009699, HG00009700 HG00009702 HG00009704 HCV151 140917029 HG00009695 HG00009716 HG00009718 HG00009691 HG00009692 HG00009693 HG00009694 HG00009696 HG00009712 HG00009713 HG00009714, HG00009715 HG00009717 M-427700 HG00009726 HG00009724 HG00009725 HG00009720 HG00009723 shanxi034 HG00009721 HG00009722 HG00009727 HG00009708 HG00009690 HG00009705 HG00009706, HG00009707 HG00009709, HG00009710 HG00009711 HG00009729 HG00009730 M-505196 1Rom
KP693413 KP163967 KF925413 KP716821 KP057133, KP192466 KP163962 KP057129 KP693394 KM987165, KM987166 KP227744 KM987168 KM987167 KP057132 KP057131 KP768452 KP784418 KM604679 KP310901 KP279725 KP057128 KP057123, KP227742, KP279724 KP057122 KP192460 KP743137 LN810062 KM987163 KM604676 KP131460 KP227740 KP131462 KM987161 KP057126 KP310902 KM987215 KP192457 KM987217, KM987164 KP279726 KP768453 KP192456 KP192458 KP310900 KP279721 KP131459 KP693409 KP057121 KP310896 KM987159 KM987212 KP256330 KP256331 KM987160, KP163956 KP279723, KP279722 KP279720 KP310898 KP057119 KP768455 KP262025
Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Kristin Kipper, Martinsried, Germany Manuela Testi, Rome, Italy Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA
DQB1*02:55 DQB1*02:56 DQB1*02:57 DQB1*02:58N DQB1*03:01:29 DQB1*03:02:18 DQB1*03:02:19 DQB1*03:170 DQB1*03:171 DQB1*03:172 DQB1*03:173 DQB1*03:174 DQB1*03:175 DQB1*03:176 DQB1*03:177 DQB1*03:178 DQB1*03:179 DQB1*04:02:09 DQB1*04:28 DQB1*04:29 DQB1*05:01:20 DQB1*05:02:13 DQB1*05:03:17 DQB1*05:91 DQB1*05:92 DQB1*06:02:24 DQB1*06:03:19 DQB1*06:168 DQB1*06:169 DQB1*06:170 DQB1*06:171 DQB1*06:172 DQB1*06:173 DQB1*06:174 DQB1*06:175 MICA*085
46
Histogenetics, Ossining, USA Histogenetics, Ossining, USA Faming Zhu, Hangzhou, China Vicky Van Sandt, Mechelen, Belgium Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Kristin Kipper, Martinsried, Germany Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Kristin Kipper, Martinsried, Germany Daniel Fuerst, Ulm, Germany
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd ⋅ Tissue Antigens, 2015, 86, 43–47 The World Health Organization retains copyright and all other rights in the manuscript of this article as submitted for publication.
S. G. E. Marsh
Nomenclature for factors of the HLA system, update February 2015
Table 2 Confirmatory Sequences HLA Allele
Cell identification
Accession number
Submitting author
A*02:01:102 A*02:436 A*11:183 A*24:02:61 A*24:225:01 A*24:287 A*26:74 A*66:22 B*15:347 B*40:249 B*58:59 C*02:06 C*07:374 C*08:95 DRB1*07:01:08
HG00009566 6311100459 HN-013007 6311100156 5351100055 386135 HN-75759-0 MG98070813 shanxi021, shanxi067 shanxi016 shanxi017 10201, 50452 shanxi036 HG00009652 HG00009410, HG00009411, HG00009412, HG00009413, HG00009414 HG00009416, HG00009417, HG00009418, HG00009419, HG00009420, HG00009421 HG00009387, HG00009388, HG00009389, HG00009390, HG00009391 HG00009398, HG00009399, HG00009400 HG00009750, HG00009751, HG00009752
KP310875 1727830 HQ226081 1726223 1726168 LN795905 HQ226095 KP262055 KP693396, KP716829 KP693390 KP693391 KP765600 KP693411 KM987205 KM455030, KM455027, KM455015, KM455016, KM455025 KM455032, KM455019, KM455020, KM455021, KM586201, KM586198
Histogenetics, Ossining, USA Zhanhui Du, Qingdao, China Histogenetics, Ossining, USA Zhanhui Du, Qingdao, China Zhi-Hui Feng, Qingdao, China Edward KL Yang, Hualien, Taiwan Histogenetics, Ossining, USA Susana G Marino, Chicago, USA Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Demei Zhang, Taiyuan, China Runying Tian, Durham, USA Demei Zhang, Taiyuan, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA
KM455044, KM586208, KM586205, KM455040, KM455042 KM455031, KM455034, KM586203 KM604685, KM604684, KM604687
Histogenetics, Ossining, USA
DRB1*07:29
DRB1*07:30 DRB1*07:32 DRB1*09:23
Table 3 Recently Published Sequences HLA Allele A*01:123N A*23:19N B*27:105 B*35:231 B*41:21 B*53:31 C*07:294 DRB1*12:51 DQA1*01:12 DQB1*02:10 DQB1*03:03:02:04 DPB1*363:01
References (3) (4) (5) (3) (3) (3) (3) (6) (3) (3) (7) (8)
Conflict of interest
The author declares no conflict of interest. References: 1. Marsh SGE, Albert ED, Bodmer WF et al. Nomenclature for factors of the HLA system, 2010. Tissue Antigens 2010: 75: 291–455.
Histogenetics, Ossining, USA
Histogenetics, Ossining, USA Histogenetics, Ossining, USA
2. Robinson J, Halliwell JA, McWilliam H, Lopez R, Parham P, Marsh SGE. The IMGT/HLA database. Nucleic Acids Res 2013: 41: D1222–7. 3. Adamek M, Klages C, Bauer M et al. Seven novel HLA alleles reflect different mechanisms involved in the evolution of HLA diversity: description of the new alleles and review of the literature. Hum Immunol 2015: 76: 30–5. 4. Gerritsen KE, Voorter CE, Joannes MO et al. RNA and protein expression of HLA-A( *)23:19Q. Hum Immunol 2015: 76: 286–91. 5. He J, He YM, Zhang W, Wang W, Zhu FM, Lv HJ. Identification a novel HLA-B*27:105 allele in a Chinese bone marrow donor by polymerase chain reaction sequence-based typing. Tissue Antigens 2015: 85: 212–3. 6. Li Y, Tang XW, Wu JY, Huang YN, Liao C. Identification of a novel HLA-DRB1 allele, HLA-DRB1*12:51, in a Chinese Cord Blood Donor. Tissue Antigens 2015: 85: 216–7. 7. Cervera I, Herraiz MA, Vidart J, Ortega S, Martinez-Laso J. Identification of the novel HLA-DQB1*03:03:02:04 allele in a Spanish individual. Tissue Antigens 2015: 85: 215–6. 8. Wang C, Wang J, Ou G, Ji X, Liu Z, Chen Q. The new allele HLA-DPB1*363:01 identified by sequence-based typing in a donor from the Chinese Marrow Donor Program. Tissue Antigens 2015: 85: 213–5.
© 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd ⋅ Tissue Antigens, 2015, 86, 43–47 The World Health Organization retains copyright and all other rights in the manuscript of this article as submitted for publication.
47
