Human Immunology xxx (2016) xxx–xxx
Contents lists available at ScienceDirect
www.ashi-hla.org
journal homepage: www.elsevier.com/locate/humimm
Nomenclature for factors of the HLA system, update December 2015 Compiled by Steven G.E. Marsh, for the WHO Nomenclature Committee for Factors of the HLA System
The following sequences have been submitted to the Nomenclature Committee since the November 2015 nomenclature update and, following agreed policy, have been assigned official allele designations [1]. Full details of all sequences will be published in a forthcoming report. Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining
to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. An additional 549 alleles were recently published but have not been included in Table 3 due to space considerations [2]. The alleles F⁄01:01:03:01, F⁄01:01:03:02, F⁄01:01:03:03 and F⁄01:01:03:04 have been renamed ⁄ ⁄ F 01:01:01:09, F 01:01:01:10, F⁄01:01:01:11 and F⁄01:01:01:12, respectively and their original designations have been deleted. All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided [3]. The IMGT/HLA Database may be accessed via the World Wide Web at: www.ebi.ac.uk/ ipd/imgt/hla
Table 1 New sequences. HLA allele
Cell identification
Accession number
Submitting author
A⁄01:199 A⁄01:200 A⁄02:157:02 A⁄02:604 A⁄02:605Q A⁄02:606 A⁄02:607 A⁄02:608N A⁄02:609 A⁄02:610 A⁄03:237 A⁄03:238 A⁄03:239 A⁄03:240 A⁄03:241 A⁄03:242 A⁄11:235Q A⁄24:327 A⁄24:328 A⁄24:329 A⁄24:330 A⁄24:331 A⁄24:332 A⁄24:333
81138557 5082501 HG00011047 HG00011045 HG00011046 HG00011048 30364 28669 96085146 378063 HG00011033 HG00011034 HG00011036 HG00011037 HG00011038 29257 388595 Xian61860 HG00011027 HG00011028 HG00011029 HG00011030 HG00011031 D324276
KU199768 LN997652 KT968838 KT895305 KT803910 KT968839 LN908989 LN908987 KU199769 LN995838 KT844477 KT968837 KT968840 KT968834 KT968836 LN908988 LN995840 KR604698 KT803906 KT943423 KU095786 KT844476 KT984958 LN909515
Daniel Fuerst, Ulm, Germany Renata Zunec, Zagreb, Croatia Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Maria Loginova, Kirov, Russia Maria Loginova, Kirov, Russia Daniel Fuerst, Ulm, Germany Edward KL Yang, Hualien, Taiwan Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Maria Loginova, Kirov, Russia Edward KL Yang, Hualien, Taiwan Jun Qi, Xian, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Edward KL Yang, Hualien, Taiwan
Refs.
(continued on next page)
⇑ Addrress for correspondence: Professor Steven G.E. Marsh, Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, London NW3 2QG, United Kingdom E-mail address: [email protected]. URLs: http://hla.alleles.org, http://www.anthonynolan.org/hig, http://www.ebi.ac.uk/ipd/imgt/hla. http://dx.doi.org/10.1016/j.humimm.2016.01.023 0198-8859/Ó 2016 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
Please cite this article in press as: S.G.E. Marsh, Nomenclature for factors of the HLA system, update December 2015, Hum. Immunol. (2016), http://dx.doi. org/10.1016/j.humimm.2016.01.023
2
S.G.E. Marsh / Human Immunology xxx (2016) xxx–xxx
Table 1 (continued) HLA allele
Cell identification
Accession number
Submitting author
A⁄24:334 A⁄32:81 A⁄32:82 A⁄32:83 A⁄32:84 A⁄68:142N B⁄07:264 B⁄07:265 B⁄14:53 B⁄18:120 B⁄39:114 B⁄40:326 B⁄40:327 B⁄44:237N B⁄44:238 B⁄46:01:21 B⁄46:65 B⁄58:02:02 C⁄01:118 C⁄01:119 C⁄02:110 C⁄02:111 C⁄02:112 C⁄03:308 C⁄03:309 C⁄03:310 C⁄03:311 C⁄03:312 C⁄03:313 C⁄04:227 C⁄04:228 C⁄04:229 C⁄04:230 C⁄05:127 C⁄06:171N C⁄06:172 C⁄06:173 C⁄06:42:02 C⁄07:26:02 C⁄07:479 C⁄07:480 C⁄07:481 C⁄07:482 C⁄07:483N C⁄07:484N C⁄07:485 C⁄07:486 C⁄07:487 C⁄12:172 C⁄15:121 C⁄16:90 C⁄16:91 C⁄16:92 C⁄17:31 DRB1⁄04:203 DRB1⁄04:204 DRB1⁄04:205 DRB1⁄04:206 DRB1⁄04:207 DRB1⁄08:03:06 DRB1⁄08:79 DRB1⁄10:01:09 DRB1⁄11:101:02 DRB1⁄11:197 DRB1⁄12:59 DRB1⁄13:213 DRB1⁄15:130 DRB1⁄15:131 DRB1⁄15:15:02 DRB1⁄16:01:11 DRB1⁄16:02:06 DRB3⁄01:01:06 DRB3⁄02:33 DRB3⁄03:04 DRB5⁄01:01:03
395968 HG00011039 HG00011040 HG00011041 HG00011042 M-494468 NT01283 M-574144 73297 M-357208 32810 399502 356043 0270904217 31214 0271508832 337638 NT01282 HG00011079 HG00011080 HG00011105 HG00011106 HG00011109 HG00011108 HG00011111 HG00011112 93013850 1434-3 TS1 HG00011113 HG00011114 HG00011115 HG00011116 HG00011103 HG00011083 HG00011085 HG00011093 HG00011084 HG00011104 HG00011078 HG00011082 HG00011087 HG00011088 HG00011089 HG00011090 HG00011091 D208295 15224828 29759 HG00011110 OC0075 HG00011094 M-568097 HG00011102 HG00011142 HG00011143 HG00011144 HG00011145 364139 HG00011148 HG00011147 BY01283 HG00011151 HG00011152 HG00011146 HG00011149 HG00011137 HG00011141 HG00011140 HG00011138 HG00011139 HG00011153 HG00011157 HG00011158 HG00011160
LN909519 KT895303 KT803904 KT895301 KT943424 LN912993 KT893448 LN912995 LN995841 LN912994 LN908990 LN909516 LN995836 KU057090 LN908991 KU243150 LN995835 KT893449 KT984964 KT984968 KT895313 KT968855 KT984966 KT943440 KT895315 KT943435 KU199770 PRJEB12062 LC105699 KU095792 KU095791 KT895318 KT803917 KT943436 KT803914 KT943434 KT895314 KT895320 KT968853 KT968856 KT968851 KT984965 KT895319 KU095790 KT803915 KT968848 LN909517 KU199764 LN908992 KT803916 SRR2182095 KU095795 LN912996 KT943437 KT895335 KT895333 KT895334 KT803922 LN995837 KT984972 KT943442 KU159285 KT844491 KU095797 KT943441 KT968862 KT895329 KT895330 KT844489 KT844490 KT895331 KU095801 KU095798 KU095803 KU095805
Edward KL Yang, Hualien, Taiwan Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Kristin Kipper, Martinsried, Germany Carolyn K Hurley, Washington DC, USA Kristin Kipper, Martinsried, Germany Jane Rowlands, Pontyclun, United Kingdom Kristin Kipper, Martinsried, Germany Maria Loginova, Kirov, Russia Edward KL Yang, Hualien, Taiwan Edward KL Yang, Hualien, Taiwan Wen Qiang, Wuhan, China Maria Loginova, Kirov, Russia Wangxia Li, Wuhan, China Edward KL Yang, Hualien, Taiwan Carolyn K Hurley, Washington DC, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Daniel Fuerst, Ulm, Germany Viktoria Zakharova, Moscow, Russia Takashi Shiina, Isehara, Japan Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Edward KL Yang, Hualien, Taiwan Daniel Fuerst, Ulm, Germany Maria Loginova, Kirov, Russia Histogenetics, Ossining, USA Bowen Liu, Shandong, China Histogenetics, Ossining, USA Kristin Kipper, Martinsried, Germany Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Edward KL Yang, Hualien, Taiwan Histogenetics, Ossining, USA Histogenetics, Ossining, USA Carolyn K Hurley, Washington DC, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA
Refs.
Please cite this article in press as: S.G.E. Marsh, Nomenclature for factors of the HLA system, update December 2015, Hum. Immunol. (2016), http://dx.doi. org/10.1016/j.humimm.2016.01.023
3
S.G.E. Marsh / Human Immunology xxx (2016) xxx–xxx Table 1 (continued) HLA allele
Cell identification
Accession number
Submitting author
DRB5⁄01:17 DQB1⁄03:219 DQB1⁄03:220 DQB1⁄03:221 DQB1⁄05:112 DQB1⁄05:113 DQB1⁄05:114 DQB1⁄05:115 DQB1⁄05:116 DQB1⁄05:117 DQB1⁄05:118 DQB1⁄05:119 DQB1⁄06:03:22 DQB1⁄06:199 DQB1⁄06:200 DPB1⁄02:01:18 DPB1⁄20:01:03 DPB1⁄520:01 DPB1⁄521:01 DPB1⁄522:01 DPB1⁄523:01 DPB1⁄524:01 DPB1⁄525:01 DPB1⁄526:01 DPB1⁄527:01 DPB1⁄528:01 DPB1⁄529:01 DPB1⁄530:01 DPB1⁄531:01 DPB1⁄532:01 DPB1⁄533:01 DPB1⁄534:01 DPB1⁄534:01 DPB1⁄535:01 DPB1⁄536:01 E⁄01:01:01:04 E⁄01:01:01:05 E⁄01:10 F⁄01:01:01:09 F⁄01:01:01:09 F⁄01:01:01:09 F⁄01:01:01:09 F⁄01:01:01:10 F⁄01:01:01:11 F⁄01:01:01:12 MICA⁄012:05 MICA⁄087
HG00011159 HG00011119 HG00011122 HG00011123 HG00011117 HG00011125 HG00011126 HG00011127 HG00011128 HG00011131 HG00011132 HG00011136 BY01294 HG00011121 BY01297 HG00011167 HG00011179 HG00011161 HG00011162 HG00011163 HG00011164 HG00011165 HG00011166 HG00011169, HG00011170 HG00011172 HG00011173 HG00011174 HG00011175, HG00011176 HG00011178 HG00011180 BY01292 BY01291 BY01291 BY01289 BY01293 30401 40423 13713 LKT3 LBF, STEINLIN, BM15 COX RPCI5 IHW01143, IHW01152 MT14B 435, 1350, 1199 SINC14, SINC15 5404S
KU095804 KT844488 KT984971 KT968860 KT803918 KU095796 KT895325 KT803920 KT968858 KT803919 KT895322 KT895324 KU204384 KT984969 KU214213 KT895338 KT803933 KT803925 KT844493 KT895337 KT968865 KT803930 KT984975 KT803926, KT803928 KT844494 KT984973 KT803932 KT844495, KT984974 KU095806 KU095808 KU173870 KU173871 KU204381 KU173873 KU204383 LN846935 LN846936 LN846934 AB088082 AF523285, AF523286, AF523289 AL669813 AB023058 AY645752 AF523290 AF523293, AF523296, AF523297 KU213643 KU199765
Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Carolyn K Hurley, Washington DC, USA Histogenetics, Ossining, USA Carolyn K Hurley, Washington DC, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Carolyn K Hurley, Washington DC, USA Carolyn K Hurley, Washington DC, USA Carolyn K Hurley, Washington DC, USA Carolyn K Hurley, Washington DC, USA Carolyn K Hurley, Washington DC, USA Marcel GJ Tilanus, Maastricht, The Netherlands Marcel GJ Tilanus, Maastricht, The Netherlands Marcel GJ Tilanus, Maastricht, The Netherlands Hidetoshi Inoko, Isehara, Kanagawa, Japan Daniel E Geraghty, Seattle, USA Stephan Beck, London, United Kingdom Hidetoshi Inoko, Isehara, Kanagawa, Japan Daniel E Geraghty, Seattle, USA Daniel E Geraghty, Seattle, USA Daniel E Geraghty, Seattle, USA Wei Tian, Changsha, China Daniel Fuerst, Ulm, Germany
Refs.
[4] [5] [6] [4] [5] [5] [5]
Table 2 Confirmatory sequences. HLA allele
Cell identification
Accession number
Submitting author
A⁄26:04 A⁄69:01 DRB3⁄02:02:06 DQB1⁄06:77N DQB1⁄06:78 DPB1⁄225:01 DPB1⁄350:01
280599 IDF HG00011154 BY01298 BY01296 BY01290 BY01295
KU233191 KU233190 KU095802 KU201527 KU204386 KU173872 KU204385
Konstantinos Barsakis, Palo Alto, USA Konstantinos Barsakis, Palo Alto, USA Histogenetics, Ossining, USA Carolyn K Hurley, Washington DC, USA Carolyn K Hurley, Washington DC, USA Carolyn K Hurley, Washington DC, USA Carolyn K Hurley, Washington DC, USA
Please cite this article in press as: S.G.E. Marsh, Nomenclature for factors of the HLA system, update December 2015, Hum. Immunol. (2016), http://dx.doi. org/10.1016/j.humimm.2016.01.023
4
S.G.E. Marsh / Human Immunology xxx (2016) xxx–xxx
Table 3 Recently published sequences. [6] HLA allele
Refs.
A⁄02:06:21 A⁄02:432 A⁄02:572 A⁄02:586 A⁄03:225 A⁄11:152 A⁄23:01:01 A⁄23:68 A⁄24:02:01:01 A⁄24:03:01 A⁄24:07:01 A⁄24:321 B⁄35:168 B⁄40:306 B⁄58:72N C⁄08:121N DRB1⁄03:112 DRB1⁄14:166N DRB1⁄15:66:02 DQB1⁄03:02:16 DQB1⁄03:139 DQB1⁄04:01:01 DQB1⁄06:126
[7] [8] [9] [10] [9] [11] [12] [13] [12] [14] [14] [15] [16] [17] [18] [19] [20] [21] [22] [20] [20] [23] [24]
[7]
[8] [9] [10]
[11]
[12]
[13] [14]
[15]
References
[16] [17]
[1] S.G.E. Marsh, E.D. Albert, W.F. Bodmer, R.E. Bontrop, B. Dupont, H.A. Erlich, M. Fernandez-Vina, D.E. Geraghty, R. Holdsworth, C.K. Hurley, M. Lau, K.W. Lee, B. Mach, M. Maiers, W.R. Mayr, C.R. Muller, P. Parham, E.W. Petersdorf, T. Sasazuki, J.L. Strominger, A. Svejgaard, P.I. Terasaki, J.M. Tiercy, J. Trowsdale, Nomenclature for factors of the HLA system, 2010, Tissue Antigens 75 (4) (2010) 291–455. [2] C.J. Hernández-Frederick, N. Cereb, A.S. Giani, J. Ruppel, A. Maraszek, J. Pingel, J. Sauter, A.H. Schmidt, S.Y. Yang, Detection of 549 new HLA alleles in potential stem cell donors from the United States, Poland and Germany, HLA 87 (1) (2016) 31–35. [3] J. Robinson, J.A. Halliwell, J.D. Hayhurst, P. Flicek, P. Parham, S.G.E. Marsh, The IPD and IMGT/HLA database: allele variant databases, Nucleic Acids Res. 43 (Database issue) (2015) D423–D431. [4] T. Shiina, G. Tamiya, A. Oka, N. Takishima, T. Yamagata, E. Kikkawa, K. Iwata, M. Tomizawa, N. Okuaki, Y. Kuwano, K. Watanabe, Y. Fukuzumi, S. Itakura, C. Sugawara, A. Ono, M. Yamazaki, H. Tashiro, A. Ando, T. Ikemura, E. Soeda, M. Kimura, S. Bahram, H. Inoko, Molecular dynamics of MHC genesis unraveled by sequence analysis of the 1,796,938-bp HLA class I region, Proc. Natl. Acad. Sci. U.S.A. 96 (23) (1999) 13282–13287. [5] C.W. Pyo, L.M. Williams, Y. Moore, H. Hyodo, S.S. Li, L.P. Zhao, N. Sageshima, A. Ishitani, D.E. Geraghty, HLA-E, HLA-F, and HLA-G polymorphism: genomic
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sequence defines haplotype structure and variation spanning the nonclassical class I genes, Immunogenetics 58 (4) (2006) 241–251. C.A. Stewart, R. Horton, R.J. Allcock, J.L. Ashurst, A.M. Atrazhev, P. Coggill, I. Dunham, S. Forbes, K. Halls, J.M. Howson, S.J. Humphray, S. Hunt, A.J. Mungall, K. Osoegawa, S. Palmer, A.N. Roberts, J. Rogers, S. Sims, Y. Wang, L.G. Wilming, J.F. Elliott, P.J. de Jong, S. Sawcer, J.A. Todd, J. Trowsdale, S. Beck, Complete MHC haplotype sequencing for common disease gene mapping, Genome Res. 14 (6) (2004) 1176–1187. K.L. Yang, J. Ng, A. Lazaro, J.H. Hung, P.Y. Lin, HLA-A⁄02:06:21, a novel variant of HLA-A⁄02:06, discovered in a Taiwanese bone marrow hematopoietic stem cell donor, HLA 87 (1) (2016) 36–37. S.Z. Jin, Z. Li, H.Y. Zou, Identification of a novel HLA-A⁄02 allele, HLA-A⁄02:432, in a Chinese individual, HLA 87 (1) (2016) 37–38. A. Balas, F. Garcia-Sanchez, J.L. Vicario, Description of two new HLA-A alleles, HLA-A⁄02:572 and HLA-A⁄03:225, HLA 87 (1) (2016) 39–40. K.L. Yang, J. Ng, A. Lazaro, J.H. Hung, P.Y. Lin, Identification of a novel HLA-A⁄02 variant, HLA-A⁄02:586, in a Taiwanese bone marrow hematopoietic stem cell donor, HLA 87 (1) (2016) 40–41. G. Shen, W. Qiang, Y.Y. Zhu, J. Zou, G.J. Liu, L. Yao, J.P. Yin, A novel allele HLAA⁄11:152 was identified by sequence-based typing in a Chinese individual, HLA 87 (1) (2016) 41–42. S.X. Wang, Y.P. Xu, H. Zhang, Genomic full-length sequence of two HLA-A alleles, A⁄23:01:01 and A⁄24:02:01:01, identified by cloning and sequencing, HLA 87 (1) (2016) 43–45. J. Street, A.J. Lemin, C. Darke, A further HLA-A⁄23 family allele – HLA-A⁄23:68, HLA 87 (1) (2016) 49–50. Y.P. Xu, S.X. Wang, Genomic full-length sequence of two HLA-A alleles, A⁄24:03:01 and A⁄24:07:01, identified by cloning and sequencing, HLA 87 (1) (2016) 46–48. M. Azkarate, S. Santos, C. Eguizabal, A. Balas, J.L. Vicario, The new HLAA⁄24:321 shows one conservative amino acid replacement compared with HLA-A⁄24:02:01, HLA 87 (1) (2016) 50–51. X.F. Li, G.J. Li, X. Zhang, J.P. Li, HLA-B⁄35:168, a novel HLA allele identified in a Chinese platelet donor, HLA 87 (1) (2016) 51–52. K.L. Yang, J.H. Hung, P.Y. Lin, HLA-B⁄40:306, a novel variant of HLA-B⁄40, discovered in a Taiwanese bone marrow hematopoietic stem cell donor, HLA 87 (1) (2016) 53–54. K.L. Yang, J.H. Hung, P.Y. Lin, A single nucleotide insertion in Exon 3 produces a novel HLA-B⁄58 null allele, HLA-B⁄58:72N, HLA 87 (1) (2016) 54–55. X. Zhang, E.F. Reed, A novel HLA-C null allele, HLA-C⁄08:121N, HLA 87 (1) (2016) 55–56. J. Street, J. Johnson, A.J. Lemin, C. Harvey, C. Darke, Immunogenetics of three novel HLA-Class II alleles: DRB1⁄03:112, DQB1⁄03:02:16 and DQB1⁄03:139, Int. J. Immunogenet. (2015). M. Testi, M. Troiano, E. Paladini, A. Di Luzio, M. Andreani, A nucleotide insertion in Exon 2 is responsible for a new HLA-DRB1 null allele, HLADRB1⁄14:166N, HLA 87 (1) (2016) 60. X.M. Nie, Y. Zhang, W.B. Qiao, C.F. Zhu, Y.R. Zhao, A novel HLA-DRB1 allele, DRB1⁄15:66:02 was identified in a Chinese potential donor by sequence-based typing, HLA 87 (1) (2016) 61–63. Y. Okudaira, K. Hosomichi, Y. Ozaki, T. Shiina, S. Mitsunaga, Correction of the HLA-DQB1⁄04:01:01 sequence at position 79 in exon 1, HLA 87 (1) (2016) 57– 58. H.A. Fakhoury, M. Alzahrani, A.S. Alaskar, A.H. Hajeer, Description of a novel HLA-DQB1 allele, HLA-DQB1⁄06:126, in the Saudi stem cell donor registry, HLA 87 (1) (2016) 58–59.
Please cite this article in press as: S.G.E. Marsh, Nomenclature for factors of the HLA system, update December 2015, Hum. Immunol. (2016), http://dx.doi. org/10.1016/j.humimm.2016.01.023
Contents lists available at ScienceDirect
www.ashi-hla.org
journal homepage: www.elsevier.com/locate/humimm
Nomenclature for factors of the HLA system, update December 2015 Compiled by Steven G.E. Marsh, for the WHO Nomenclature Committee for Factors of the HLA System
The following sequences have been submitted to the Nomenclature Committee since the November 2015 nomenclature update and, following agreed policy, have been assigned official allele designations [1]. Full details of all sequences will be published in a forthcoming report. Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from the EMBL, GenBank or DDBJ data libraries. Although accession numbers have been assigned by the data-libraries and most sequences are already available, there is still the possibility that an author may not yet have allowed the sequence to be released; in such a case you will have to contact the submitting author directly. Additional information pertaining
to new sequences is often included in the publications describing these alleles; a listing of recent publications that describe new HLA sequences is given in Table 3. An additional 549 alleles were recently published but have not been included in Table 3 due to space considerations [2]. The alleles F⁄01:01:03:01, F⁄01:01:03:02, F⁄01:01:03:03 and F⁄01:01:03:04 have been renamed ⁄ ⁄ F 01:01:01:09, F 01:01:01:10, F⁄01:01:01:11 and F⁄01:01:01:12, respectively and their original designations have been deleted. All new and confirmatory sequences should now be submitted directly to the WHO Nomenclature Committee for Factors of the HLA System via the IMGT/HLA Database using the sequence submission tool provided [3]. The IMGT/HLA Database may be accessed via the World Wide Web at: www.ebi.ac.uk/ ipd/imgt/hla
Table 1 New sequences. HLA allele
Cell identification
Accession number
Submitting author
A⁄01:199 A⁄01:200 A⁄02:157:02 A⁄02:604 A⁄02:605Q A⁄02:606 A⁄02:607 A⁄02:608N A⁄02:609 A⁄02:610 A⁄03:237 A⁄03:238 A⁄03:239 A⁄03:240 A⁄03:241 A⁄03:242 A⁄11:235Q A⁄24:327 A⁄24:328 A⁄24:329 A⁄24:330 A⁄24:331 A⁄24:332 A⁄24:333
81138557 5082501 HG00011047 HG00011045 HG00011046 HG00011048 30364 28669 96085146 378063 HG00011033 HG00011034 HG00011036 HG00011037 HG00011038 29257 388595 Xian61860 HG00011027 HG00011028 HG00011029 HG00011030 HG00011031 D324276
KU199768 LN997652 KT968838 KT895305 KT803910 KT968839 LN908989 LN908987 KU199769 LN995838 KT844477 KT968837 KT968840 KT968834 KT968836 LN908988 LN995840 KR604698 KT803906 KT943423 KU095786 KT844476 KT984958 LN909515
Daniel Fuerst, Ulm, Germany Renata Zunec, Zagreb, Croatia Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Maria Loginova, Kirov, Russia Maria Loginova, Kirov, Russia Daniel Fuerst, Ulm, Germany Edward KL Yang, Hualien, Taiwan Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Maria Loginova, Kirov, Russia Edward KL Yang, Hualien, Taiwan Jun Qi, Xian, China Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Edward KL Yang, Hualien, Taiwan
Refs.
(continued on next page)
⇑ Addrress for correspondence: Professor Steven G.E. Marsh, Anthony Nolan Research Institute, Royal Free Hospital, Pond Street, London NW3 2QG, United Kingdom E-mail address: [email protected]. URLs: http://hla.alleles.org, http://www.anthonynolan.org/hig, http://www.ebi.ac.uk/ipd/imgt/hla. http://dx.doi.org/10.1016/j.humimm.2016.01.023 0198-8859/Ó 2016 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.
Please cite this article in press as: S.G.E. Marsh, Nomenclature for factors of the HLA system, update December 2015, Hum. Immunol. (2016), http://dx.doi. org/10.1016/j.humimm.2016.01.023
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S.G.E. Marsh / Human Immunology xxx (2016) xxx–xxx
Table 1 (continued) HLA allele
Cell identification
Accession number
Submitting author
A⁄24:334 A⁄32:81 A⁄32:82 A⁄32:83 A⁄32:84 A⁄68:142N B⁄07:264 B⁄07:265 B⁄14:53 B⁄18:120 B⁄39:114 B⁄40:326 B⁄40:327 B⁄44:237N B⁄44:238 B⁄46:01:21 B⁄46:65 B⁄58:02:02 C⁄01:118 C⁄01:119 C⁄02:110 C⁄02:111 C⁄02:112 C⁄03:308 C⁄03:309 C⁄03:310 C⁄03:311 C⁄03:312 C⁄03:313 C⁄04:227 C⁄04:228 C⁄04:229 C⁄04:230 C⁄05:127 C⁄06:171N C⁄06:172 C⁄06:173 C⁄06:42:02 C⁄07:26:02 C⁄07:479 C⁄07:480 C⁄07:481 C⁄07:482 C⁄07:483N C⁄07:484N C⁄07:485 C⁄07:486 C⁄07:487 C⁄12:172 C⁄15:121 C⁄16:90 C⁄16:91 C⁄16:92 C⁄17:31 DRB1⁄04:203 DRB1⁄04:204 DRB1⁄04:205 DRB1⁄04:206 DRB1⁄04:207 DRB1⁄08:03:06 DRB1⁄08:79 DRB1⁄10:01:09 DRB1⁄11:101:02 DRB1⁄11:197 DRB1⁄12:59 DRB1⁄13:213 DRB1⁄15:130 DRB1⁄15:131 DRB1⁄15:15:02 DRB1⁄16:01:11 DRB1⁄16:02:06 DRB3⁄01:01:06 DRB3⁄02:33 DRB3⁄03:04 DRB5⁄01:01:03
395968 HG00011039 HG00011040 HG00011041 HG00011042 M-494468 NT01283 M-574144 73297 M-357208 32810 399502 356043 0270904217 31214 0271508832 337638 NT01282 HG00011079 HG00011080 HG00011105 HG00011106 HG00011109 HG00011108 HG00011111 HG00011112 93013850 1434-3 TS1 HG00011113 HG00011114 HG00011115 HG00011116 HG00011103 HG00011083 HG00011085 HG00011093 HG00011084 HG00011104 HG00011078 HG00011082 HG00011087 HG00011088 HG00011089 HG00011090 HG00011091 D208295 15224828 29759 HG00011110 OC0075 HG00011094 M-568097 HG00011102 HG00011142 HG00011143 HG00011144 HG00011145 364139 HG00011148 HG00011147 BY01283 HG00011151 HG00011152 HG00011146 HG00011149 HG00011137 HG00011141 HG00011140 HG00011138 HG00011139 HG00011153 HG00011157 HG00011158 HG00011160
LN909519 KT895303 KT803904 KT895301 KT943424 LN912993 KT893448 LN912995 LN995841 LN912994 LN908990 LN909516 LN995836 KU057090 LN908991 KU243150 LN995835 KT893449 KT984964 KT984968 KT895313 KT968855 KT984966 KT943440 KT895315 KT943435 KU199770 PRJEB12062 LC105699 KU095792 KU095791 KT895318 KT803917 KT943436 KT803914 KT943434 KT895314 KT895320 KT968853 KT968856 KT968851 KT984965 KT895319 KU095790 KT803915 KT968848 LN909517 KU199764 LN908992 KT803916 SRR2182095 KU095795 LN912996 KT943437 KT895335 KT895333 KT895334 KT803922 LN995837 KT984972 KT943442 KU159285 KT844491 KU095797 KT943441 KT968862 KT895329 KT895330 KT844489 KT844490 KT895331 KU095801 KU095798 KU095803 KU095805
Edward KL Yang, Hualien, Taiwan Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Kristin Kipper, Martinsried, Germany Carolyn K Hurley, Washington DC, USA Kristin Kipper, Martinsried, Germany Jane Rowlands, Pontyclun, United Kingdom Kristin Kipper, Martinsried, Germany Maria Loginova, Kirov, Russia Edward KL Yang, Hualien, Taiwan Edward KL Yang, Hualien, Taiwan Wen Qiang, Wuhan, China Maria Loginova, Kirov, Russia Wangxia Li, Wuhan, China Edward KL Yang, Hualien, Taiwan Carolyn K Hurley, Washington DC, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Daniel Fuerst, Ulm, Germany Viktoria Zakharova, Moscow, Russia Takashi Shiina, Isehara, Japan Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Edward KL Yang, Hualien, Taiwan Daniel Fuerst, Ulm, Germany Maria Loginova, Kirov, Russia Histogenetics, Ossining, USA Bowen Liu, Shandong, China Histogenetics, Ossining, USA Kristin Kipper, Martinsried, Germany Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Edward KL Yang, Hualien, Taiwan Histogenetics, Ossining, USA Histogenetics, Ossining, USA Carolyn K Hurley, Washington DC, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA
Refs.
Please cite this article in press as: S.G.E. Marsh, Nomenclature for factors of the HLA system, update December 2015, Hum. Immunol. (2016), http://dx.doi. org/10.1016/j.humimm.2016.01.023
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S.G.E. Marsh / Human Immunology xxx (2016) xxx–xxx Table 1 (continued) HLA allele
Cell identification
Accession number
Submitting author
DRB5⁄01:17 DQB1⁄03:219 DQB1⁄03:220 DQB1⁄03:221 DQB1⁄05:112 DQB1⁄05:113 DQB1⁄05:114 DQB1⁄05:115 DQB1⁄05:116 DQB1⁄05:117 DQB1⁄05:118 DQB1⁄05:119 DQB1⁄06:03:22 DQB1⁄06:199 DQB1⁄06:200 DPB1⁄02:01:18 DPB1⁄20:01:03 DPB1⁄520:01 DPB1⁄521:01 DPB1⁄522:01 DPB1⁄523:01 DPB1⁄524:01 DPB1⁄525:01 DPB1⁄526:01 DPB1⁄527:01 DPB1⁄528:01 DPB1⁄529:01 DPB1⁄530:01 DPB1⁄531:01 DPB1⁄532:01 DPB1⁄533:01 DPB1⁄534:01 DPB1⁄534:01 DPB1⁄535:01 DPB1⁄536:01 E⁄01:01:01:04 E⁄01:01:01:05 E⁄01:10 F⁄01:01:01:09 F⁄01:01:01:09 F⁄01:01:01:09 F⁄01:01:01:09 F⁄01:01:01:10 F⁄01:01:01:11 F⁄01:01:01:12 MICA⁄012:05 MICA⁄087
HG00011159 HG00011119 HG00011122 HG00011123 HG00011117 HG00011125 HG00011126 HG00011127 HG00011128 HG00011131 HG00011132 HG00011136 BY01294 HG00011121 BY01297 HG00011167 HG00011179 HG00011161 HG00011162 HG00011163 HG00011164 HG00011165 HG00011166 HG00011169, HG00011170 HG00011172 HG00011173 HG00011174 HG00011175, HG00011176 HG00011178 HG00011180 BY01292 BY01291 BY01291 BY01289 BY01293 30401 40423 13713 LKT3 LBF, STEINLIN, BM15 COX RPCI5 IHW01143, IHW01152 MT14B 435, 1350, 1199 SINC14, SINC15 5404S
KU095804 KT844488 KT984971 KT968860 KT803918 KU095796 KT895325 KT803920 KT968858 KT803919 KT895322 KT895324 KU204384 KT984969 KU214213 KT895338 KT803933 KT803925 KT844493 KT895337 KT968865 KT803930 KT984975 KT803926, KT803928 KT844494 KT984973 KT803932 KT844495, KT984974 KU095806 KU095808 KU173870 KU173871 KU204381 KU173873 KU204383 LN846935 LN846936 LN846934 AB088082 AF523285, AF523286, AF523289 AL669813 AB023058 AY645752 AF523290 AF523293, AF523296, AF523297 KU213643 KU199765
Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Carolyn K Hurley, Washington DC, USA Histogenetics, Ossining, USA Carolyn K Hurley, Washington DC, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Histogenetics, Ossining, USA Carolyn K Hurley, Washington DC, USA Carolyn K Hurley, Washington DC, USA Carolyn K Hurley, Washington DC, USA Carolyn K Hurley, Washington DC, USA Carolyn K Hurley, Washington DC, USA Marcel GJ Tilanus, Maastricht, The Netherlands Marcel GJ Tilanus, Maastricht, The Netherlands Marcel GJ Tilanus, Maastricht, The Netherlands Hidetoshi Inoko, Isehara, Kanagawa, Japan Daniel E Geraghty, Seattle, USA Stephan Beck, London, United Kingdom Hidetoshi Inoko, Isehara, Kanagawa, Japan Daniel E Geraghty, Seattle, USA Daniel E Geraghty, Seattle, USA Daniel E Geraghty, Seattle, USA Wei Tian, Changsha, China Daniel Fuerst, Ulm, Germany
Refs.
[4] [5] [6] [4] [5] [5] [5]
Table 2 Confirmatory sequences. HLA allele
Cell identification
Accession number
Submitting author
A⁄26:04 A⁄69:01 DRB3⁄02:02:06 DQB1⁄06:77N DQB1⁄06:78 DPB1⁄225:01 DPB1⁄350:01
280599 IDF HG00011154 BY01298 BY01296 BY01290 BY01295
KU233191 KU233190 KU095802 KU201527 KU204386 KU173872 KU204385
Konstantinos Barsakis, Palo Alto, USA Konstantinos Barsakis, Palo Alto, USA Histogenetics, Ossining, USA Carolyn K Hurley, Washington DC, USA Carolyn K Hurley, Washington DC, USA Carolyn K Hurley, Washington DC, USA Carolyn K Hurley, Washington DC, USA
Please cite this article in press as: S.G.E. Marsh, Nomenclature for factors of the HLA system, update December 2015, Hum. Immunol. (2016), http://dx.doi. org/10.1016/j.humimm.2016.01.023
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S.G.E. Marsh / Human Immunology xxx (2016) xxx–xxx
Table 3 Recently published sequences. [6] HLA allele
Refs.
A⁄02:06:21 A⁄02:432 A⁄02:572 A⁄02:586 A⁄03:225 A⁄11:152 A⁄23:01:01 A⁄23:68 A⁄24:02:01:01 A⁄24:03:01 A⁄24:07:01 A⁄24:321 B⁄35:168 B⁄40:306 B⁄58:72N C⁄08:121N DRB1⁄03:112 DRB1⁄14:166N DRB1⁄15:66:02 DQB1⁄03:02:16 DQB1⁄03:139 DQB1⁄04:01:01 DQB1⁄06:126
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