Nodular regenerative hyperplasia of the liver: an important portal hypertension in non-cirrhotic patients
In our lxnpital
over the last 10 years a diagnosis of nodular regenerative hyperplasia was made ior II pa!ients.
pcrccnt of thcsc patients had portal hypertension,
was the second most frequent
‘lomake the dingnoria.
21% of all our patients with portal hypertension
between malignant disease (multiple
ease). the use of cytotoxic or immunosuppressive nodular regenerstwe
cause of portal hypertension
a surgica! biopsy is most helpful.
tic derangement of the liver architecture on histoloeg may still be overlooked.
,991: 12 94-w Elrevier
Sixty-nine and a nooin patiet +?
In this study a suggestive relation waskond
myelogenous leukaemta. Leydig cell turnour
dn.ga and nodular regenerative hyperplasia.
hyperplasia was observed in patients following
and HcNdgkin’s dis-
a high tote of
ahnormzdnies developed in these patients after a period ranging from 8 month? to 3 years of immunosuppressiveoiothempj.
devrlop in thw
hvcr function abnot’malittes were, howevr,
the treatment ofchotce, for the prevention
of rh.: mtrohcpmlc vasculature due to cirrho-
si\ ii the mart common c~ubcof portal hypertension rope and the IJ.S.A.
evidence of extensive
oerc ?hagenl vances and ascites may also develop in patient, with B non-cirrhotic
clinical evidence of portal hypertension
wth this disorder
Methods The files of all patients with clinical manifestations portal
seen in the University
patients with liver biopsies and/or autopsy materiai cating nodular regenerative hyperplasia.
1.1 this paper we rrport
tients with nodular regenerative hyperplasia
on nine patients with nodular re-
byperplana as the cause of portal hypertension
in patwntr wnh a non-cxrhotic
liver. In addition. four pa-
Nijmegcn during the last IO years were studied to identify
usually haw normal or nearly normal livct function tests. ;encratwc
and the development of regenerative rme
tients without presented.
which indicate paren-
of recurrent variceal haemorrhage.
collagen depositloll )wdulo.
certiun biochemxal chymal liver
usually mild. Since hepatic encephalopathy is not likely to
patients with nodular regenerative hyperplasia a decompressive shunt operation is a good alternative
tions of portal
fied from the files of all patients who had undergone liver
In these eawr, &me stained with hematoxylin-
emin and reticulir
had to be available.
All slides were re-
viewed and a diagnasis was assigned on the baris of gnerally
Diffuse or zonal micronodularny
dence of cirrhosis.
hepatocytes in concentric of the nodules.
on the peripher)
and five fsnalos.
I and 2. 13 patients (eight male