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DOI: 10.1159/000511849 Received: 6/8/2020 Accepted: 9/24/2020 Published(online): 9/30/2020 --------------Unifocal versus multiple ileal neuroendocrine tumors location: an embryological origin Kalifi M. Walter T. Milot L. Hervieu V. Millot I. Gibert B. Roche C. Forestier J. LombardBohas C. Pasquer A. Poncet G. --------------ISSN: 0028-3835 (Print), eISSN: 1423-0194 (Online) https://www.karger.com/NEN Neuroendocrinology ---------------
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Disclaimer: Accepted, unedited article not yet assigned to an issue. The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publisher and the editor(s). The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content.
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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. © 2020 S. Karger AG, Basel ---------------
Unifocal versus multiple ileal neuroendocrine tumors location: an embryological origin
Maroin Kalifi (MK)a, Thomas Walter (TW), MD, PhDb,c,d, Laurent Milot (LM), MD, PhDc,d,e Valérie Hervieu (VH), MD, PhDc,d,f, Ingrid Millot (IM), MDg, Benjamin Gibert (BG), PhDc,h, Colette Roche (CR), PhDc, Julien Forestier (JF), MDb, Catherine Lombard-Bohas (CLB), MDb, Arnaud Pasquer (AP), MDa,, Gilles Poncet (GP), MD, PhDa,c,d
Hospices Civils de Lyon, Hôpital Edouard Herriot, Chirurgie digestive, 69437 Lyon cedex
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Hospices Civils de Lyon, Hôpital Edouard Herriot, Service de Gastroentérologie et
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03, France
INSERM, UMR 1052- UMR5286, UMR 1032 Lyon Cancer Research Center, Faculté
Laennec, 69372 Lyon cedex 08, France
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d’Oncologie Digestive, 69437 Lyon cedex 03, France
Université de Lyon, Université Claude Bernard Lyon 1, 69622 Villeurbanne cedex, France
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Hospices Civils de Lyon, Hôpital Edouard Herriot, Radiologie, 69437 Lyon cedex 03,
Hospices Civils de Lyon, Hôpital Edouard Herriot, Service Central d’Anatomie et Cytologie
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France
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Pathologiques, 69437 Lyon cedex 03, France g
Hospices Civils de Lyon, Hôpital Édouard Herriot, Service d’anesthésie-réanimation, 69437
Lyon cedex 03, France h
CNRS Rhône Auvergne, BP 61335, 69609 Villeurbanne cedex, France
Corresponding author: Thomas Walter Gastroenterology and Medical Oncology Hôpital Edouard Herriot, University Hospital of Lyon 1
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Running title: Small-intestinal neuroendocrine tumors location
5 place d’Arsonval, Lyon Cedex 03, 69437, France Phone number: +33 (0)4 72 11 73 98 Fax number: +33 (0)4 72 11 96 91 Email address:
[email protected] Keywords: Small intestine; surgery; neuroendocrine tumors; multifocal, location.
Synopsis: Location of unifocal and multiple small-intestinal neuroendocrine tumors according to the superior mesenteric artery axis.
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Category: Original study
Text word count: 2764
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Abstract word count: 241
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Conflicts of interest: None Funding source: None
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Tables: 1, Figures: 2
Abstract Introduction: Small-intestinal neuroendocrine tumors (SI-NET) are situated preferentially within the ileum. The aim was to describe a potential difference in location between unifocal and multiple ileal-NET. Patients and Methods: Between December 2010 and December 2019, all consecutive patients who underwent resection in our European Neuroendocrine Tumor Society Center of Excellence, of at least one non-duodenal SI-NET, were retrospectively included. The main
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objective was to prove that multiple ileal-NET were mostly located on the left-side of the
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superior mesenteric artery (SMA) axis (defined as 40cm from the ileocecal valve), and
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unifocal ones on the right-side.
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Results: Ninety-four patients were included, six with unifocal jejunal-NET located 35cm
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(range, 10-60) from the duodenojejunal angle (DJA), 44 (47%) with unifocal ileal-NET, and 44 (47%) with multiple ileal-NET. The median number of tumors in multiple ileal-NET was 7
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(range, 2-95), within a median small bowel segment of 105cm (10-240). The median length
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between the proximal tumor and the DJA was 428cm (300-635) and 540cm (350-725) for the
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distal one; 40 (91%) of them were located on the left side of the SMA axis. In contrast,
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unifocal ileal-NET were located at a median distance of 577cm (305-820) from the DJA (p