ORIGINAL ARTICLE LUNG FUNCTION
Blood eosinophil level and lung function trajectories: cross-sectional and longitudinal studies in European cohorts Ida Mogensen1,2, Judith M. Vonk 3,4, Sara R.A. Wijnant H. Marike Boezen3,4, Guy Brusselle 5,6,8, Lies Lahousse and Andrei Malinovschi 1
5,6,7
, Xingwu Zhou1,2, , Christer Janson 2
6,7
Affiliations: 1Dept of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden. 2Dept of Medical Sciences, Lung-, Allergy- and Sleep Research, Uppsala University, Uppsala, Sweden. 3Dept of Epidemiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands. 4 Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands. 5Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium. 6Dept of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands. 7Dept of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium. 8Dept of Respiratory Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands. Correspondence: Ida Mogensen, Akademiska sjukhuset, 751 85 Uppsala, Sweden. E-mail: [email protected]
ABSTRACT Background: Elevated blood eosinophils have been associated with lower lung function and are believed to be associated with accelerated lung function decline. Method: Blood eosinophils were measured in four cohorts:
Blood eosinophil level and lung function trajectories: cross-sectional and longitudinal studies in European cohorts Ida Mogensen1,2, Judith M. Vonk 3,4, Sara R.A. Wijnant H. Marike Boezen3,4, Guy Brusselle 5,6,8, Lies Lahousse and Andrei Malinovschi 1
5,6,7
, Xingwu Zhou1,2, , Christer Janson 2
6,7
Affiliations: 1Dept of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden. 2Dept of Medical Sciences, Lung-, Allergy- and Sleep Research, Uppsala University, Uppsala, Sweden. 3Dept of Epidemiology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands. 4 Groningen Research Institute for Asthma and COPD (GRIAC), University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands. 5Dept of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium. 6Dept of Epidemiology, Erasmus Medical Centre, Rotterdam, The Netherlands. 7Dept of Bioanalysis, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium. 8Dept of Respiratory Medicine, Erasmus Medical Centre, Rotterdam, The Netherlands. Correspondence: Ida Mogensen, Akademiska sjukhuset, 751 85 Uppsala, Sweden. E-mail: [email protected]
ABSTRACT Background: Elevated blood eosinophils have been associated with lower lung function and are believed to be associated with accelerated lung function decline. Method: Blood eosinophils were measured in four cohorts:
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