Acta Paediatr Scand 79: 1225-1 234, 1990
Nitrofurantoin versus Trimethoprim Prophylaxis in Recurrent Urinary Tract Infection in Children A Randomized, Double-blind Study Managing committee: L. BRENDSTRUP, K. HJELT, K. E. PETERSEN, S. PETERSEN, E. A. ANDERSEN, P. S. DAUGBJERG, B. R. STAGEGAARD, 0. H. NIELSEN, R. VEJLSGAARD and G. SCHOU Other participants: A. HANSEN, V. HVORSLEV, V. BRENDHOLT JENSEN, B. PAGH, A. PERREGAARD, H. SARDEMANN, T. S0RENSEN and C. VRANG From the Departments of Paediatrics, Hillerod Hospital, Roskilde Hospital, Sundby Hospital, Nestved Hospital, Rigshospitalet, Gentojie Hospital, Glostrup Hospital and the Department of Clinical Microbiology, Herlev Hospital, University of Copenhagen, Denmark
ABSTRAm. Copenhagen study group of urinary tract infections in children (Departments of Paediatrics, H i l l e d Hospital, Roskilde Hospital, Sundby Hospital, Nastved Hospital, Rigshospitalet, Gentofte Hospital, Glostrup Hospital and Department of Clinical Microbiology, Herlev Hospital, University of Copenhagen, Denmark.) Nitrofurantoin versus trimethoprim prophylaxis in recurrent urinary tract infection in children. A randomized, double-blind study. Acta Paediatr Scand 79: 1225,1990. The efficiency of nitrofurantoin and trimethoprim prophylaxis in preventing recurrent urinary tract infections (UTI) was compared by means of actuarial percentage recurrence-free c w e s in a randomized, double blind study in 130 children (126 girls, 4 boys) aged 1 to 14 years (mean 7.5). The children received the antibiotics for 6 months. Nitrofurantoin proved to be the most efficient prophylactic drug in patients with abnormal urography and/or reflux (n=60) as evaluated by actuarial percentage recurrence-free analysis (p= 0.0025). However, no differences was found in patients without urinary tract abnormalities. Nitrofurantoin prophylaxis altered neither the pattern of resistance nor the bacteriological constellation, while patients receiving trimethoprim prophylaxis had 76 % trimethoprim resistant bacteria during prophylaxis, compared with 8 % before (p
Nitrofurantoin versus Trimethoprim Prophylaxis in Recurrent Urinary Tract Infection in Children A Randomized, Double-blind Study Managing committee: L. BRENDSTRUP, K. HJELT, K. E. PETERSEN, S. PETERSEN, E. A. ANDERSEN, P. S. DAUGBJERG, B. R. STAGEGAARD, 0. H. NIELSEN, R. VEJLSGAARD and G. SCHOU Other participants: A. HANSEN, V. HVORSLEV, V. BRENDHOLT JENSEN, B. PAGH, A. PERREGAARD, H. SARDEMANN, T. S0RENSEN and C. VRANG From the Departments of Paediatrics, Hillerod Hospital, Roskilde Hospital, Sundby Hospital, Nestved Hospital, Rigshospitalet, Gentojie Hospital, Glostrup Hospital and the Department of Clinical Microbiology, Herlev Hospital, University of Copenhagen, Denmark
ABSTRAm. Copenhagen study group of urinary tract infections in children (Departments of Paediatrics, H i l l e d Hospital, Roskilde Hospital, Sundby Hospital, Nastved Hospital, Rigshospitalet, Gentofte Hospital, Glostrup Hospital and Department of Clinical Microbiology, Herlev Hospital, University of Copenhagen, Denmark.) Nitrofurantoin versus trimethoprim prophylaxis in recurrent urinary tract infection in children. A randomized, double-blind study. Acta Paediatr Scand 79: 1225,1990. The efficiency of nitrofurantoin and trimethoprim prophylaxis in preventing recurrent urinary tract infections (UTI) was compared by means of actuarial percentage recurrence-free c w e s in a randomized, double blind study in 130 children (126 girls, 4 boys) aged 1 to 14 years (mean 7.5). The children received the antibiotics for 6 months. Nitrofurantoin proved to be the most efficient prophylactic drug in patients with abnormal urography and/or reflux (n=60) as evaluated by actuarial percentage recurrence-free analysis (p= 0.0025). However, no differences was found in patients without urinary tract abnormalities. Nitrofurantoin prophylaxis altered neither the pattern of resistance nor the bacteriological constellation, while patients receiving trimethoprim prophylaxis had 76 % trimethoprim resistant bacteria during prophylaxis, compared with 8 % before (p
