PharmacologyBiochemistry& Behavior, Vol. 39, pp. 781-786. PergamonPress pie, 1991. Printed in the U.S.A.
0091-3057/91 $3.00 + .00
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Nimodipine Improves Spatial Working Memory and Elevates Hippocampal Acetylcholine in Young Rats A H A R O N L E V Y , 1 R O B E R T O M . K O N G , M I C H A E L J. S T I L L M A N , B A R B A R A S H U K 1 T T - H A L E , * T A M A R K A D A R , 1 T E R R Y M . R A U C H 2 A N D H A R R I S R. L I E B E R M A N 3
U.S. Army Research Institute o f Environmental Medicine, Natick, MA 01760 *GEO-Centers, Inc., Newton Centre, MA 02159 R e c e i v e d 28 J a n u a r y 1991 LEVY, A., R. M. KONG, M. J. STILLMAN, B. SHUKrIT-HALE, T. KADAR, T. M. RAUCH AND H. R. LIEBERMAN.
Nimodipine improves spatial working memory and elevates hippocampal acetylcholine in young rats. PHARMACOL BIOCHEM BEHAV 39(3) 781-786, 1991.--The calcium channel blocker nimodipine has been reported to improve cognitive performance in aged and brain-damaged animals. In the present study, the effects of nimodipine and placebo on spatial working memory and hippocampai acetylcholine were studied in young Fischer-344 rats. Nimodipine or placebo was administered via subcutaneously implanted, sustained-release pellets. Each active pellet contained 20 mg of nimodipine and released the drug over approximately 21 days. Two days after the drug or placebo pellets were implanted, training in the 8-arm radial maze started and continued for 12 days. Rats were required to learn a win-shift strategy. Nimodipine-treated animals learned the maze more rapidly than a placebotreated group as indicated by the number of correct choices out of the first eight arms visited (p
0091-3057/91 $3.00 + .00
RAPID COMMUNICATION
Nimodipine Improves Spatial Working Memory and Elevates Hippocampal Acetylcholine in Young Rats A H A R O N L E V Y , 1 R O B E R T O M . K O N G , M I C H A E L J. S T I L L M A N , B A R B A R A S H U K 1 T T - H A L E , * T A M A R K A D A R , 1 T E R R Y M . R A U C H 2 A N D H A R R I S R. L I E B E R M A N 3
U.S. Army Research Institute o f Environmental Medicine, Natick, MA 01760 *GEO-Centers, Inc., Newton Centre, MA 02159 R e c e i v e d 28 J a n u a r y 1991 LEVY, A., R. M. KONG, M. J. STILLMAN, B. SHUKrIT-HALE, T. KADAR, T. M. RAUCH AND H. R. LIEBERMAN.
Nimodipine improves spatial working memory and elevates hippocampal acetylcholine in young rats. PHARMACOL BIOCHEM BEHAV 39(3) 781-786, 1991.--The calcium channel blocker nimodipine has been reported to improve cognitive performance in aged and brain-damaged animals. In the present study, the effects of nimodipine and placebo on spatial working memory and hippocampai acetylcholine were studied in young Fischer-344 rats. Nimodipine or placebo was administered via subcutaneously implanted, sustained-release pellets. Each active pellet contained 20 mg of nimodipine and released the drug over approximately 21 days. Two days after the drug or placebo pellets were implanted, training in the 8-arm radial maze started and continued for 12 days. Rats were required to learn a win-shift strategy. Nimodipine-treated animals learned the maze more rapidly than a placebotreated group as indicated by the number of correct choices out of the first eight arms visited (p
