American Journal of Medical Genetics 42857 (1992)
Letter to the Editor Newly Recognized Congenital Progeroid Disorder To the Editor:
head, a progeroid relatively small face with apparently low-set ears, a thin upper lip and a prominent mandible. She was involved in a lively conversation with her comPetty et al. [ 19901 recently reported the case of a girl panion, who was older than she, and gave the impression with congenital progeroid manifestations whose clinical of being intellectually normal. picture was not suggestive of any previously defined I regret that I did not have the opportunity to obtain disorder. However, she did bear a striking resemblance more detailed information about the girl or to examine to a female patient whose case was described many years her. As she looked exactly like the two patients previago and to whom reference has sometimes been made in ously reported by Petty et al., I have no doubt that I have the literature. Comparison of the two patients showed observed the “third case” of a now well-defined synsuch a striking similarity that it was reasonable to con- drome. sider the disorder a separate entity, a previously unreREFERENCE cognized congenital progeroid syndrome of genetic origin. Petty EM, Laxova R, Wiedemann H-R (1990):Previouslyunrecognized On 4 September 1991, in a street in the centre of congenital progeroid disorder. Am J Med Genet 35: 383-387. Frankfurt (FRG), I observed another girl with the same characteristic phenotype. She was between 18 and 20 Hans-Rudolf Wiedemann years old, of conspicuously small stature and noticeably Department of Pediatrics thin. As her pelvis was relatively large, I believe it can University of Kiel be assumed that her sexual development was normal. Kiel, Germany The girl had noticeably sparse scalp hair, a broad fore-
Received for publication September 30, 1991. Address reprint requests to Hans-Rudolf Wiedemann, M.D., Department of Pediatrics, University of Kiel, Schwanenweg 20, D-2300 Kiel 1, Germany.
0 1992 Wiley-Liss, Inc.
Letter to the Editor Newly Recognized Congenital Progeroid Disorder To the Editor:
head, a progeroid relatively small face with apparently low-set ears, a thin upper lip and a prominent mandible. She was involved in a lively conversation with her comPetty et al. [ 19901 recently reported the case of a girl panion, who was older than she, and gave the impression with congenital progeroid manifestations whose clinical of being intellectually normal. picture was not suggestive of any previously defined I regret that I did not have the opportunity to obtain disorder. However, she did bear a striking resemblance more detailed information about the girl or to examine to a female patient whose case was described many years her. As she looked exactly like the two patients previago and to whom reference has sometimes been made in ously reported by Petty et al., I have no doubt that I have the literature. Comparison of the two patients showed observed the “third case” of a now well-defined synsuch a striking similarity that it was reasonable to con- drome. sider the disorder a separate entity, a previously unreREFERENCE cognized congenital progeroid syndrome of genetic origin. Petty EM, Laxova R, Wiedemann H-R (1990):Previouslyunrecognized On 4 September 1991, in a street in the centre of congenital progeroid disorder. Am J Med Genet 35: 383-387. Frankfurt (FRG), I observed another girl with the same characteristic phenotype. She was between 18 and 20 Hans-Rudolf Wiedemann years old, of conspicuously small stature and noticeably Department of Pediatrics thin. As her pelvis was relatively large, I believe it can University of Kiel be assumed that her sexual development was normal. Kiel, Germany The girl had noticeably sparse scalp hair, a broad fore-
Received for publication September 30, 1991. Address reprint requests to Hans-Rudolf Wiedemann, M.D., Department of Pediatrics, University of Kiel, Schwanenweg 20, D-2300 Kiel 1, Germany.
0 1992 Wiley-Liss, Inc.
