American Journal of Medical Genetics 42:400 (1992)
Letter to the Editor -
New Lethal Acrofacial Dysostosis Syndrome To the Editor: I read with interest the papers by Rodriquez et al. [1990] and F'ryns and Kleckowska [1991] describing a lethal acrofacial dysostosis. These cases are similar to those described in 1987 by Hecht et al. in which two sibs had the same pattern of anomalies and one subsequently died of respiratory insufficiency. This condition is distinct from the Nager syndrome. Our report and that of of Rodriquez et al. [1990] with 3 affected sibs confirm an autosomal recessive pattern of inheritance of this lethal acrofacial dysostosis.
Received for publication June 10, 1991. Address reprint requests to Jacqueline T. Hecht, Department of Pediatrics, University of Texas Medical School at Houston, P.O. Box 20708, Houston, TX 77225.
0 1992 Wiley-Liss, Inc.
REFERENCES Fryns J-P,Kleckowska A (1991):New lethal acrofacial dysostosissyndrome. Am J Med Genet 39:223-224. Hecht JT, Immken LL, Harris LF, Malini S, Scott CI (1987):The Nager Syndrome. Am J Med Genet 27:965-969. Rodriquez JI, PalaciosJ, Urioste M (1990):New acrofacialdysostosisin 3 siblings. Am J Med Genet 35484-489.
Jacqueline T. Hecht Department of Pediatrics University of Texas Medical School at Houston Houston, Texas
Letter to the Editor -
New Lethal Acrofacial Dysostosis Syndrome To the Editor: I read with interest the papers by Rodriquez et al. [1990] and F'ryns and Kleckowska [1991] describing a lethal acrofacial dysostosis. These cases are similar to those described in 1987 by Hecht et al. in which two sibs had the same pattern of anomalies and one subsequently died of respiratory insufficiency. This condition is distinct from the Nager syndrome. Our report and that of of Rodriquez et al. [1990] with 3 affected sibs confirm an autosomal recessive pattern of inheritance of this lethal acrofacial dysostosis.
Received for publication June 10, 1991. Address reprint requests to Jacqueline T. Hecht, Department of Pediatrics, University of Texas Medical School at Houston, P.O. Box 20708, Houston, TX 77225.
0 1992 Wiley-Liss, Inc.
REFERENCES Fryns J-P,Kleckowska A (1991):New lethal acrofacial dysostosissyndrome. Am J Med Genet 39:223-224. Hecht JT, Immken LL, Harris LF, Malini S, Scott CI (1987):The Nager Syndrome. Am J Med Genet 27:965-969. Rodriquez JI, PalaciosJ, Urioste M (1990):New acrofacialdysostosisin 3 siblings. Am J Med Genet 35484-489.
Jacqueline T. Hecht Department of Pediatrics University of Texas Medical School at Houston Houston, Texas
