Clinical Practice
Neuromyelitis Optica Spectrum Disorder Associated with Cervical Spondylosis Yuan Zhou, Lin Zhu, Hui‑Lin Cheng, Yi‑Xing Lin Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu 210002, China
Key words: Anti‑aquaporin‑4 Antibody; Cervical Spondylosis; Magnetic Resonance Imaging; Neuromyelitis Optica Spectrum Disorder
Neuromyelitis optica spectrum disease (NMOSD) refers to a group of related disease, in which potential pathogenesis is similar to neuromyelitis optica (NMO), but clinical involvement does not exactly correspond to the diagnosis of NMO. Owing to varied clinical manifestations, it is apt to be misdiagnosed. We report a case of NMOSD with cervical spondylosis and discuss the experience of diagnosis.
as NMOSD as well as cervical spondylosis. Then, she received methylprednisolone (500 mg) impact therapy and sequential reduction of hormone therapy. Fifteen days later, MRI [Figure 1b] showed cervical and thoracic spinal cord lesions were significantly reduced. Her symptoms of upper limbs pain, numbness of chest, and abdomen had improved markedly and was discharged.
A 44‑year‑old woman was admitted to our hospital with a 10‑day history of ache of double upper limbs and numbness on the trunk below the chest and bilateral thighs. Ten days before, she had an onset of ache of double upper limbs without apparent inducement. At the same time, she developed trembling on hands when writing and numbness between the chest and bilateral knees, which were unable to be alleviated. At admission, she presented with hypoesthesia of superficial sensibility from bilateral costal margins to knees, positive bilateral Hoffman sign, and Babinski sign. Magnetic resonance imaging (MRI) [Figure 1a] of cervical vertebrae showed: (1) Cervical intervertebral disc herniation (C3–C7); (2) Intramedullary lesions with edema (C2–T2); (3) Cervical spondylolisthesis (C3–C5). She was admitted to our hospital with a presumptive diagnosis of cervical spondylosis and intramedullary lesions with edema (C2–T2). After admission, she was given dehydration, anti‑inflammatory, nerve nutrition, and symptomatic treatment immediately. Subsequent lumbar puncture showed results of cerebrospinal fluid routine were normal with normal protein, glucose, and chloride levels. Serum aquaporin‑4 (AQP‑4) antibody was tested by enzyme‑linked immunosorbent assay and showed positive. Also, visual evoked potential, brainstem auditory evoked potential, and somatosensory evoked potential were normal. All told that she was diagnosed
After discharge, oral prednisone tablets in sequential treatment had been given, and drug dosage had been reduced to 1 tablet/day gradually. Three months later, the patient developed upper limbs and armpit pain, and lightning like feeling on bilateral thighs when she dipped her head. Serum AQP‑4 antibody showed strongly positive. Cervical MRI [Figure 1c] showed cervical and thoracic spinal cord lesions like last time. NMOSD recurrence was considered. Methylprednisolone impact therapy and sequential reduction of hormone therapy were given. And after treatment, review of MRI [Figure 1d] showed the lesions significantly reduced. The symptoms of the patient partly alleviated and she was discharged. Followed up to date, the patient had taken drugs all the time and showed no recurrence [Figure 1e].
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Address for correspondence: Dr. Yi‑Xing Lin, Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing, Jiangsu 210002, China E‑Mail: [email protected] This is an open access article distributed under the terms of the Creative Commons Attribution‑NonCommercial‑ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non‑commercially, as long as the author is credited and the new creations are licensed under the identical terms. For reprints contact: [email protected]
Website: www.cmj.org
DOI: 10.4103/0366-6999.169110
3112
NMOSD is a kind of autoimmune disease with single or recurrent course, which causes selective, invasive injury of optic nerve and/or spinal cord. It is characterized by
© 2015 Chinese Medical Journal ¦ Produced by Wolters Kluwer ‑ Medknow
Received: 08‑06‑2015 Edited by: Yi Cui How to cite this article: Zhou Y, Zhu L, Cheng HL, Lin YX. Neuromyelitis Optica Spectrum Disorder Associated with Cervical Spondylosis. Chin Med J 2015;128:3112-3. Chinese Medical Journal ¦ November 20, 2015 ¦ Volume 128 ¦ Issue 22
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Figure 1: Sagittal T2‑weighted magnetic resonance imaging of neuromyelitis optica spectrum disease. (a) Scan on first admission demonstrating cervical interver tebral disc herniation (C3–C7), intramedullary lesions with edema (C2–T2). (b) Fifteen days post first admission demonstrating significant reduced intramedullary lesions. (c) Second admission demonstrating recurrent intramedullary lesions. (d) Ten days post second admission demonstrating reduced recurrent intramedullary lesions. (e) Half a year post second discharge demonstrating near complete resolution of intramedullary lesions.
inflammation and necrosis in pathology. It is more common in women and young adults. Because of its diverse clinical manifestations, it is easy to misdiagnose.[1] The definition of NMOSD was proposed by Wingerchuk et al. in 2007.[2] According to the criteria, this case showed lesions with longitudinally extensive transverse myelitis (more than three vertebrae) mainly located in the cervical and thoracic spinal cord. The lesions involving most of the gray matter and white matter located in the central spinal cord. Originally, the patient was diagnosed as cervical spondylosis owing to the clinical manifestations and MRI findings. As the relevant examination including AQP‑4 antibody had been gradually improved, the final diagnosis of NMOSD was achieved. In 2004, Lennon found a specific NMO‑IgG antibody in the serum of patients with NMO and used it as a marker of biological, immunological diagnosis for NMO. Its sensitivity and specificity were 73% and 91%, respectively.
In 2005, Lennon et al.[3] confirmed the specific target antigen of NMO‑IgG was AQP‑4 by double indirect immunofluorescence. In 2006, Wingerchunk et al.[4] bringed positive serum AQP‑4 antibody into the main support standard included in the NMO diagnostic criteria revised. The guide for diagnosis and therapy of NMO by European Union on neurology in 2010 not only defined the NMOSD, but also put forward positive serum or cerebrospinal fluid AQP‑4 antibody as the main support standard in the path for NMOSD diagnosis. This NMOSD patient was accompanied by cervical spondylosis. As clinical manifestations and MRI findings of this patient are very similar to cervical spondylosis with spinal cord degeneration simply, it is easy to be misdiagnosed. Positive serum AQP‑4 antibody is very helpful for diagnosis. Although NMOSD has a severe disability rate, it often shows spontaneous remission and relapse.[5] In acute exacerbation, hormone therapy can achieve good relieve rate. Because it is easy to relapse, immunosuppression drugs are recommended to prevent its recurrence. Symptoms of this case improved obviously after hormone therapy. And one recurrence had appeared in this case until now. In conclusion, NMOSD is easily misdiagnosed as cervical spondylosis when the lesions are confined to the cervical and thoracic spinal cord. It will result in a severe outcome without timely diagnosis. Thus, early diagnosis is very important. In addition to typical clinical manifestations and imaging, detection of serum AQP‑4 antibody is significant for a diagnosis.
Financial support and sponsorship Nil.
Conflicts of interest
There are no conflicts of interest.
References 1. Buch D, Dehais C, Savatovsky J, Mokhtari K, Gout O, Marignier R, et al. Spinal cord tumour misdiagnosed as seropositive neuromyelitis optica spectrum disorder. Pract Neurol 2015;15:228‑9. 2. Ringelstein M, Metz I, Ruprecht K, Koch A, Rappold J, Ingwersen J, et al. Contribution of spinal cord biopsy to diagnosis of aquaporin‑4 antibody positive neuromyelitis optica spectrum disorder. Mult Scler 2013;20:882-8. 3. Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med 2005;202:473-7. 4. Wingerchuk DM, Lennon VA, Lucchinetti CF, Pittock SJ, Weinshenker BG. The spectrum of neuromyelitis optica. Lancet Neurol 2007;6:805-15. 5. Elsone L, Kitley J, Luppe S, Lythgoe D, Mutch K, Jacob S, et al. Long‑term efficacy, tolerability and retention rate of azathioprine in 103 aquaporin‑4 antibody‑positive neuromyelitis optica spectrum disorder patients: A multicentre retrospective observational study from the UK. Mult Scler 2014;20:1533‑40.
Chinese Medical Journal ¦ November 20, 2015 ¦ Volume 128 ¦ Issue 22
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Neuromyelitis Optica Spectrum Disorder Associated with Cervical Spondylosis Yuan Zhou, Lin Zhu, Hui‑Lin Cheng, Yi‑Xing Lin Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, Nanjing, Jiangsu 210002, China
Key words: Anti‑aquaporin‑4 Antibody; Cervical Spondylosis; Magnetic Resonance Imaging; Neuromyelitis Optica Spectrum Disorder
Neuromyelitis optica spectrum disease (NMOSD) refers to a group of related disease, in which potential pathogenesis is similar to neuromyelitis optica (NMO), but clinical involvement does not exactly correspond to the diagnosis of NMO. Owing to varied clinical manifestations, it is apt to be misdiagnosed. We report a case of NMOSD with cervical spondylosis and discuss the experience of diagnosis.
as NMOSD as well as cervical spondylosis. Then, she received methylprednisolone (500 mg) impact therapy and sequential reduction of hormone therapy. Fifteen days later, MRI [Figure 1b] showed cervical and thoracic spinal cord lesions were significantly reduced. Her symptoms of upper limbs pain, numbness of chest, and abdomen had improved markedly and was discharged.
A 44‑year‑old woman was admitted to our hospital with a 10‑day history of ache of double upper limbs and numbness on the trunk below the chest and bilateral thighs. Ten days before, she had an onset of ache of double upper limbs without apparent inducement. At the same time, she developed trembling on hands when writing and numbness between the chest and bilateral knees, which were unable to be alleviated. At admission, she presented with hypoesthesia of superficial sensibility from bilateral costal margins to knees, positive bilateral Hoffman sign, and Babinski sign. Magnetic resonance imaging (MRI) [Figure 1a] of cervical vertebrae showed: (1) Cervical intervertebral disc herniation (C3–C7); (2) Intramedullary lesions with edema (C2–T2); (3) Cervical spondylolisthesis (C3–C5). She was admitted to our hospital with a presumptive diagnosis of cervical spondylosis and intramedullary lesions with edema (C2–T2). After admission, she was given dehydration, anti‑inflammatory, nerve nutrition, and symptomatic treatment immediately. Subsequent lumbar puncture showed results of cerebrospinal fluid routine were normal with normal protein, glucose, and chloride levels. Serum aquaporin‑4 (AQP‑4) antibody was tested by enzyme‑linked immunosorbent assay and showed positive. Also, visual evoked potential, brainstem auditory evoked potential, and somatosensory evoked potential were normal. All told that she was diagnosed
After discharge, oral prednisone tablets in sequential treatment had been given, and drug dosage had been reduced to 1 tablet/day gradually. Three months later, the patient developed upper limbs and armpit pain, and lightning like feeling on bilateral thighs when she dipped her head. Serum AQP‑4 antibody showed strongly positive. Cervical MRI [Figure 1c] showed cervical and thoracic spinal cord lesions like last time. NMOSD recurrence was considered. Methylprednisolone impact therapy and sequential reduction of hormone therapy were given. And after treatment, review of MRI [Figure 1d] showed the lesions significantly reduced. The symptoms of the patient partly alleviated and she was discharged. Followed up to date, the patient had taken drugs all the time and showed no recurrence [Figure 1e].
Access this article online Quick Response Code:
Address for correspondence: Dr. Yi‑Xing Lin, Department of Neurosurgery, Jinling Hospital, School of Medicine, Nanjing University, 305 East Zhongshan Road, Nanjing, Jiangsu 210002, China E‑Mail: [email protected] This is an open access article distributed under the terms of the Creative Commons Attribution‑NonCommercial‑ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non‑commercially, as long as the author is credited and the new creations are licensed under the identical terms. For reprints contact: [email protected]
Website: www.cmj.org
DOI: 10.4103/0366-6999.169110
3112
NMOSD is a kind of autoimmune disease with single or recurrent course, which causes selective, invasive injury of optic nerve and/or spinal cord. It is characterized by
© 2015 Chinese Medical Journal ¦ Produced by Wolters Kluwer ‑ Medknow
Received: 08‑06‑2015 Edited by: Yi Cui How to cite this article: Zhou Y, Zhu L, Cheng HL, Lin YX. Neuromyelitis Optica Spectrum Disorder Associated with Cervical Spondylosis. Chin Med J 2015;128:3112-3. Chinese Medical Journal ¦ November 20, 2015 ¦ Volume 128 ¦ Issue 22
a
b
c
d
e
Figure 1: Sagittal T2‑weighted magnetic resonance imaging of neuromyelitis optica spectrum disease. (a) Scan on first admission demonstrating cervical interver tebral disc herniation (C3–C7), intramedullary lesions with edema (C2–T2). (b) Fifteen days post first admission demonstrating significant reduced intramedullary lesions. (c) Second admission demonstrating recurrent intramedullary lesions. (d) Ten days post second admission demonstrating reduced recurrent intramedullary lesions. (e) Half a year post second discharge demonstrating near complete resolution of intramedullary lesions.
inflammation and necrosis in pathology. It is more common in women and young adults. Because of its diverse clinical manifestations, it is easy to misdiagnose.[1] The definition of NMOSD was proposed by Wingerchuk et al. in 2007.[2] According to the criteria, this case showed lesions with longitudinally extensive transverse myelitis (more than three vertebrae) mainly located in the cervical and thoracic spinal cord. The lesions involving most of the gray matter and white matter located in the central spinal cord. Originally, the patient was diagnosed as cervical spondylosis owing to the clinical manifestations and MRI findings. As the relevant examination including AQP‑4 antibody had been gradually improved, the final diagnosis of NMOSD was achieved. In 2004, Lennon found a specific NMO‑IgG antibody in the serum of patients with NMO and used it as a marker of biological, immunological diagnosis for NMO. Its sensitivity and specificity were 73% and 91%, respectively.
In 2005, Lennon et al.[3] confirmed the specific target antigen of NMO‑IgG was AQP‑4 by double indirect immunofluorescence. In 2006, Wingerchunk et al.[4] bringed positive serum AQP‑4 antibody into the main support standard included in the NMO diagnostic criteria revised. The guide for diagnosis and therapy of NMO by European Union on neurology in 2010 not only defined the NMOSD, but also put forward positive serum or cerebrospinal fluid AQP‑4 antibody as the main support standard in the path for NMOSD diagnosis. This NMOSD patient was accompanied by cervical spondylosis. As clinical manifestations and MRI findings of this patient are very similar to cervical spondylosis with spinal cord degeneration simply, it is easy to be misdiagnosed. Positive serum AQP‑4 antibody is very helpful for diagnosis. Although NMOSD has a severe disability rate, it often shows spontaneous remission and relapse.[5] In acute exacerbation, hormone therapy can achieve good relieve rate. Because it is easy to relapse, immunosuppression drugs are recommended to prevent its recurrence. Symptoms of this case improved obviously after hormone therapy. And one recurrence had appeared in this case until now. In conclusion, NMOSD is easily misdiagnosed as cervical spondylosis when the lesions are confined to the cervical and thoracic spinal cord. It will result in a severe outcome without timely diagnosis. Thus, early diagnosis is very important. In addition to typical clinical manifestations and imaging, detection of serum AQP‑4 antibody is significant for a diagnosis.
Financial support and sponsorship Nil.
Conflicts of interest
There are no conflicts of interest.
References 1. Buch D, Dehais C, Savatovsky J, Mokhtari K, Gout O, Marignier R, et al. Spinal cord tumour misdiagnosed as seropositive neuromyelitis optica spectrum disorder. Pract Neurol 2015;15:228‑9. 2. Ringelstein M, Metz I, Ruprecht K, Koch A, Rappold J, Ingwersen J, et al. Contribution of spinal cord biopsy to diagnosis of aquaporin‑4 antibody positive neuromyelitis optica spectrum disorder. Mult Scler 2013;20:882-8. 3. Lennon VA, Kryzer TJ, Pittock SJ, Verkman AS, Hinson SR. IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel. J Exp Med 2005;202:473-7. 4. Wingerchuk DM, Lennon VA, Lucchinetti CF, Pittock SJ, Weinshenker BG. The spectrum of neuromyelitis optica. Lancet Neurol 2007;6:805-15. 5. Elsone L, Kitley J, Luppe S, Lythgoe D, Mutch K, Jacob S, et al. Long‑term efficacy, tolerability and retention rate of azathioprine in 103 aquaporin‑4 antibody‑positive neuromyelitis optica spectrum disorder patients: A multicentre retrospective observational study from the UK. Mult Scler 2014;20:1533‑40.
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