Accepted Manuscript Neurodevelopmental Outcomes in Very Low Birth Weight Infants Using Aminophylline for the Treatment of Apnea Shu-Leei Tey, Wei-Te Lee, Pei-Lun Lee, Chu-Chong Lu, Hsiu-Lin Chen PII:

S1875-9572(15)00087-X

DOI:

10.1016/j.pedneo.2015.03.013

Reference:

PEDN 476

To appear in:

Pediatrics & Neonatology

Received Date: 11 March 2014 Revised Date:

26 February 2015

Accepted Date: 18 March 2015

Please cite this article as: Tey S-L, Lee W-T, Lee P-L, Lu C-C, Chen H-L, Neurodevelopmental Outcomes in Very Low Birth Weight Infants Using Aminophylline for the Treatment of Apnea, Pediatrics and Neonatology (2015), doi: 10.1016/j.pedneo.2015.03.013. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

PEDN-D-14-00070_After Eng Edited_final

ACCEPTED MANUSCRIPT Original article Neurodevelopmental Outcomes in Very Low Birth Weight Infants Using Aminophylline for the Treatment of Apnea

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Running title: AMINOPHYLLINE AND NEURODEVELOPMENTAL OUTCOMES

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Shu-Leei Tey1,3, Wei-Te Lee1, Pei-Lun Lee1, Chu-Chong Lu1, Hsiu-Lin Chen1,2

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Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan [1] Department of Respiratory Therapy, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan [2]

Corresponding author: Hsiu-Lin Chen

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Department of Pediatrics, E-da Hospital, I-Shou University, Kaohsiung, Taiwan [3]

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Division of Neonatology, Department of Pediatrics, Kaohsiung Medical University Hospital No. 100, TzYou 1st road, Kaohsiung City 80756, Taiwan

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Email address: [email protected] (H.L. Chen) Tel: 886-7-3121101 ext 6529

1

ACCEPTED MANUSCRIPT Abstract Background: Aminophylline has been widely used in the treatment of apneic episodes in

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premature infants. Animal models suggest caution in the use of aminophylline as it may increase the cerebral metabolic rate and decrease the rate of anoxic survival in neonates. This study aimed to evaluate the neurological outcomes in very low birth weight (VLBW) infants

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treated with aminophylline for apnea in our neonatal intensive care unit (NICU).

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Methods: All VLBW infants (body birth weight 20 seconds or 20 seconds or

Neurodevelopmental Outcomes in Very Low Birth Weight Infants Using Aminophylline for the Treatment of Apnea.

Aminophylline has been widely used in the treatment of apneic episodes in premature infants. Animal models suggest caution in the use of aminophylline...
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