TERATOLOGY 41:603-610 (1990)
NEUROBEHAVIORAL TERATOLOGY SOClETY FOURTEENTH ANNUAL MEETING JUNE 7-10, 1990 VICTORIA CONFERENCE CENTRE VICTORIA, BRITISH COLUMBIA, CANADA Program and Abstracts NEUROBEHAVIORAL TERATOLOGY SOCIETY OFFICERS 1989-1990 (Expiration of Term) W. PIZZI, President-Elect C. KIMMEL, President T. BURBACHER, Treasurer S. RICE, Secretary J. MARTIN, Council (1990) D. HUTCHINGS, Liaison Council N. LAUGHLIN, Council (1991) C. RANDALL, Council (1992) R. BUTCHER 1977-79 P. RODIER 1979-80 R. HOAR 1980-81 D. HUTCHINGS 1981-82
PAST PRESIDENTS of the SOCIETY E. RILEY 1982-83 J. ADAMS 1986-87 E. ABEL 1983-84 L. MIDDAUGH 1987-88 C. VORHEES 1984-85 J. BUELKE-SAM 1988-89 R. JENSH 1985-86
FINANCE M. Geyer (1991) B. Strupp (1990)
C. VORHEES, Chairperson (1993) C. KIMMEL (1993) J. ADAMS (1993) E. RILEY (1993)
STANDING COMMITTEES (Expiration of Term) MEMBERSHIP C. Driscoll (1990) S. Schantz (1991) A. Temple (1992)
NOMINATIONS R. Holson (1990) E. Lochry (1991) L. Middaugh (1992)
PUBLICATIONS L. MIDDAUGH (1992) S. RICE (1992) E. LOCHRY (1992)
1989-1990 AD HOC COMMITTEES DEVELOPMENTAL NEUROTOXICITY PROTECTION (AD HOC AWARDS N. Laughlin B.K. Nelson SUBCOMMITTEE 1 S. Rice C. Vorhees T. Burbacher J. Adams R. Holson D. Hutchings R. Butcher R. Smith T. Fico 0 1990 WILEY-LISS, INC.
w. PIZZI (1991) N. LAUGHLIN (1991) E. ABEL (1991)
BY-LAWS S. Rice R. Holson R. Smith
604
NEUROBEHAVIORAL TERATOLOGY SOCIETY PROGRAM
The Neurobehavioral Teratology Society would like to acknowledge and thank the following companies for their financial support of the 1990 annual meeting. ABBOTT LABORATORIES ARGUS RESEARCH LABORATORIES BRISTOL-MYERS COMPANY HOFFMANN-LAROCHE, INC. R.W. JOHNSON PHARMACEUTICAL RES. INST.
MARCH OF DIMES PROCTOR & GAMBLE COMPANY SAN DIEGO INSTRUMENTS SMITH KLINE BEECHAM
PROGRAM THURSDAY, JUNE 7 9.00
A M -6:OO P M
REGISTRATION-Plaza
Prefunction
3:OO-4:00
PM
PUBLICATIONS COMMITTEE-Metchosin (HI
4:OO-5:00
PM
DEVELOPMENTAL NEUROTOXICITY PROTECTION COMMITTEEMetchosin (H)
6:30-8:OO
PM
PRESIDENTS RECEPTION-Plaza Prefunction
8:OO-1O:OO
PM
COUNCIL MEETING-Sooke (Dj
FRIDAY, JUNE 8 9:40
WELCOME & ANNOUNCEMENTS: C.A. Kimmel-Esquimalt
(C)
SYMPOSIUM I: LONG-TERM EFFECTS OF PERINATAL AND NEONATAL INSULT Organizer and Moderator: R.M. Booze Esquimalt (C), 9:50-11:50 9:50
INTRODUCTION-R.M.
Booze
9:55
NTS 1 LIFETIME EFFECTS OF PERINATAL EXPOSURE TO DRUGS OF ABUSE IN THE RAT MODEL. J.C. Martin, University of Washington, Seattle, WA
10:20
NTS 2 ENVIRONMENTAL INTERVENTIONS AND INFLUENCES IN AGING. J.A. Joseph and G.S. Roth, National Institute on Aging, Baltimore, MD
10:45
NTS 3 MEMORIES, SYNAPSES AND TOXINS: A LIFESPAN APPROACH. T.L. Petit, University of Toronto, Scarborough, Ontario, Canada
11:lO
NTS 4 LONG-TERM EFFECTS OF NEONATAL BRAIN DAMAGE: CROSSSECTIONAL AND LONGITUDINAL STUDIES OF BRAIN PLASTICITY. R.M. Booze, Bowman Gray School of Medicine, Winston-Salem, NC
11:35
DISCUSSION
11:50
LUNCH
NEUROBEHAVIORAL TERATOLOGY SOCIETY PROGRAM
605
SYMPOSIUM 11: EARLY LEARNING AND MEMORYiANIMAL AND HUMAN MODELS Organizer and Moderator: C.F. Mactutus Esquimalt (C), 1:45-4:15 1:45
INTRODUCTION-C.F.
Mactutus
1:50
NTS 5 THE ORIENTING RESPONSE AS A MEASURE OF INFORMATION PROCESSING. R. Richardson, H. Hayne and B.A Campbell, Princeton University, Princeton, N J
2:15
NTS 6 TASTE AVERSION LEARNING IN THE DEVELOPING RAT. H. Hoffman, Knox College, Galesburg, IL
2:40
NTS 7 ASSOCIATIVE LEARNING IN INFANT RATS AND NEONATAL HUMAN INFANTS. R.M. Sullivan, University of Oklahoma, Norman, OK
3:05
NTS 8 LONG-TERM MEMORY IN HUMAN INFANTS AND ITS RELATION TO INTELLIGENCE-TEST PERFORMANCE IN CHILDHOOD. J.W. Fagen, St. John’s University, Jamaica, NY
3:30
NTS 9 ONTOGENY OF SPATIAL LEARNINGIMEMORY. C.F. Mactutus, Bennett College, Greensboro, NC
355
DISCUSSION
4:15
BREAK
4:30-5:00
NTS 10 INVITED ADDRESS: UPDATE ON THE USEPAS DEVELOPMENTAL NEUROTOXICITY STUDY PROTOCOL. E.Z. Francis, US Environmental Protection Agency, Washington, DC-Esquimalt (C)
SATURDAY, JUNE 9 8:30-9:30
INVITED LECTURE: COCAINE: TERATOGEN EPIDEMIC, T.H. Shepard, University of Washington, Seattle, WA; Discussant: Donald E. Hutchings, New York State Psychiatric Institute, New York, NY. Co-sponsored with the Teratology Society Theatre, 8:30-9:30
9:30-1O:OO
BREAK SYMPOSIUM 111: SOCIAL AND ECONOMIC COSTS OF ALCOHOL EXPOSURE DURING PREGNANCY Co-sponsored with the Public Affairs Committee of the Teratology Society Co-chairs: T.A. Marks and E.P. Riley Theatre, 1O:OO -1 2:OO
1o:oo
INTRODUCTION. T.A. Marks, Upjohn Company, Kalamazoo, MI
10:05
FETAL ALCOHOL SYNDROME AMONG NATIVE AMERICANS. J.M. Aase, University of New Mexico School of Medicine, Albuquerque, NM
10:30
NEW UNDERSTANDINGS OF THE FACE AND BRAIN IN FETAL ALCOHOL SYNDROME. S. Clarren, Children’s Hospital and Medical Center, Seattle, WA
10:55
LONG-TERM NEUROBEHAVIORAL EFFECTS OF PRENATAL ALCOHOL EXPOSURE. A.P. Streissguth, University of Washington, Seattle, WA
11:20
EFFECTS OF PRENATAL ALCOHOL EXPOSURE ON GROWTH AND MORPHOLOGY. N.L. Day, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA
606
NEUROBEHAVIORAL TERATOLOGY SOCIETY PROGRAM
11:45
DISCUSSION
12:oo
LUNCH SYMPOSIUM IV: ISOTRETINOIN: CLINICAL DEMONSTRATION OF THE PRINCIPLES OF BEHAVIORAL TERATOGENESIS Organizers and Moderators: J . Adams and E.J. Lammer Esquimalt (C), 1:30-3:30
1:30
NTS 11 STUDY DESIGN OF PHASE 2 OF THE LONGITUDINAL STUDY OF INFANTS EXPOSED TO ISOTRETINOIN IN UTERO. E.J. Lammer, J . Adams, B. Battaglia and L.B. Holmes, California Birth Defects Monitoring Program, Emeryville, CA, and University of Massachusetts and Massachusetts General Hospital, Boston, MA
2:oo
NTS 12 HIGH INCIDENCE OF INTELLECTUAL DEFICITS IN 5 YEAR OLD CHILDREN EXPOSED TO ISOTRETINOIN “IN UTERO.” J. Adams, University of Massachusetts, Boston, MA
2:30
NTS 13 A COMPARISON OF RETINOID TERATOGENESIS IN ANIMALS AND HUMANS. C.V. Vorhees, Children’s Hospital Research Foundation and University of Cincinnati, Cincinnati, OH
3:OO
DISCUSSION
3:15
BREAK
3:30
BUSINESS MEETING-Esquimalt
4:30-8:00
Free Time
(C)
POSTER SESSION AND DISCUSSION Posters should be set up after 1:00 P.M. Saturday and removed by midnight. Posters Attended: 8:OO-9:30 P.M. Saturday, Saanich (A) Refreshments available from 8:OO-9:30 P M . Poster Discussion: 9:45-10:45 P.M. Saturday, Esquimalt (C) NTS 14 DIFFERENTIAL BEHAVIORAL TERATOLOGY FOLLOWING PRENATAL ADMINISTRATION OF SODIUM PHENYTOIN OR PHENYTOIN ACID. W.J. Pizzi and R. Jersey, Northeastern Illinois University, Chicago, IL NTS 15 WORKING MEMORY AND THE OLTON RADIAL-ARM MAZE: EFFECTS OF MATERNAL PHENYLKETONURIA AND PRENATAL PHENYTOIN IN RATS. W.P. Weisenburger, D.R. Minck, K.D. Acuff and C.V. Vorhees, Children’s Hospital Research Foundation, Cincinnati, OH, and International Research and Development Corporation, Mattawan, MI NTS 16 STRUCTURE-ACTIVITY BEHAVIORAL TERATOGENIC ANALYSIS OF THE HYDANTOIN ANTICONVULSANTS. D.R. Minck, K.D. Acuff and C.V. Vorhees. Children’s Hospital Research Foundation and University of Cincinnati, Cincinnati, OH NTS 17 A NEW METHOD FOR EVALUATING THE AIR-RIGHTING REFLEX IN DEVELOPING RATS. K.D. Acuff, D.R. Minck and C.V. Vorhees. Chidren’s Hospital Research Foundation and University of Cincinnati, Cincinnati, OH NTS 18 EFFECTS O F SUBCUTANEOUS ADMINISTRATION OF COCAINE DURING GESTATION ON MATERNAL AND OFFSPRING BODY WEIGHTS: THREE YEARS WORTH OF DATA. C.J. Heyser and L.P. Spear, SUNY-Binghamton, Binghamton, NY
NEUROBEHAVIORAL TERATOLOGY SOCIETY PROGRAM
607
NTS 19 PRENATAL EXPOSURE OF COCAINE IN RATS PRODUCES SIGNIFICANT ALTERATIONS IN STRIATAL DOPAMINE (D2) RECEPTOR BINDING IN OFFSPRING. S.F. Ali, F.M. Scalzo, N.A. Frambes and L.P. Spear. National Center for Toxicological Research, Jefferson, AR, and SUNY-Binghamton, Binghamton, NY NTS 20 THE ONTOGENY OF BEHAVIORAL SENSITIZATION AND TOLERANCE TO PHENCYCLIDINE (PCP) AND COCAINE. F.M. Scalzo and R.R. Holson. National Center for Toxicological Research, Jefferson, AR NTS 21 PRENATAL COCAINE EXPOSURE IN THE RAT: DEVELOPMENTAL DELAY IN THE BRAINSTEM AUDITORY EVOKED POTENTIAL. M.W. Church and G.W. Overbeck, Wayne State University School of Medicine, Detroit, MI NTS 22 EFFECTS O F PRENATAL ALCOHOL AND COCAINE EXPOSURES ON STRESS ADAPTATION. P. Bilitzke and M.W. Church, Wayne State University School of Medicine, Detroit, MI NTS 23 EXPOSURE TO A SINGLE LARGE ORAL DOSE OF ETHANOL DURING EARLY GESTATION ALTERS SPONTANEOUS ACTIVITY IN WEANLING C57 MICE. R. Dumas, A. Rabe, E.A. Sersen and S. Delia, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY NTS 24 IN UTERO ETHANOL EFFECTS ON GROWTH AND ON FOOD-REINFORCED BEHAVIOR: DEPENDENCE ON GESTATIONAL STAGE OF EXPOSURE. L.D. Middaugh, Medical University of South Carolina, Charleston, SC NTS 25 EFFECT O F PRENATAL ETHANOL EXPOSURE ON NEONATAL BEHAVIOR. G.D. Gentry and L.D. Middaugh, College of Charleston and Medical University of South Carolina, Charleston, SC NTS 26 MEMORY DEFICITS AND LIFE ADJUSTMENT IN ADULTS WITH FETAL ALCOHOL SYNDROME. J.K. Gray and A.P. Streissguth, University of Washington Medical School, Seattle, WA NTS 27 EFFECTS OF CHRONIC AMPHETAMINE ON WEIGHT GAIN AND ACTIVITY OF FEMALE RATS EXPOSED PRENATALLY TO ETHANOL. M.L. Pilati and J.H. Hannigan, SUNYAlbany, Albany, NY NTS 28 STARTLE HYPERREACTIVITY FOLLOWING REPEATED PRENATAL N20 EXPOSURE IN SD RATS. S.A. Rice, A. Carughi and M.T. Serra, Stanford University and VA Medical Center, Palo Alto, CA NTS 29 DEVELOPMENTAL TOXICOLOGY OF THE DOPAMINE AGONIST PERGOLIDE MESYLATE IN CD-1 MICE. J . Buelke-Sam, R.A. Byrd, J.A. Johnson, J.P. Tizzano and N.V. Owen, Eli Lilly & Co., Greenfield, IN NTS 30 DEVELOPMENTAL TOXICOLOGY STUDIES OF PICENADOL ADMINISTERED IN THE DIET TO RATS. J.P. Tizzano, J.A. Hoyt, G.K. Hanasono, D.R. Helton and J . Buelke-Sam, Eli Lilly & Co., Greenfield, IN NTS 31 SELECTIVE NEURODEVELOPMENTAL EFFECTS OF EXCESS DIETARY ALUMINUM (AL) IN MICE. M.S. Golub, C.L. Keen and M.E. Gershwin, University of California, Davis, Davis, CA NTS 32 EFFECTS OF PRENATAL METHYL MERCURY EXPOSURE UPON BEHAVIOR AND NEUROPATHOLOGY. K.J. Robinson and B. Broxup, Bio-Research Laboratories, Ltd., Senneville, Quebec, Canada (Introduced by G.E. Dearlove) NTS 33 CORTICOSTERONE HYPERSECRETION IN PREWEANLING RATS EXPOSED NEONATALLY TO TRIMETHYLTIN (TMT). M.E. Stanton and C.M. Kuhn, U.S. Environmental Protection Agency, Research Triangle Park, and Duke University, Durham, NC (Introduced by C.A. Kimmel) NTS 34 ASSOCIATION OF NEONATAL REFLEX DEVELOPMENT WITH BIRTH WEIGHT DEFICITS. J. Singh, Stillman College, Tuscaloosa, AL
608
NEUROBEHAVIORAL TERATOLOGY SOCIETY PROGRAM
NTS 35 MORPHINE-INDUCED CHANGES IN PREPROENKEPHALIN MRNA IN NEONATAL RAT BRAIN. A. Tempel, Hillside HospitaliLIJMC, Glen Oaks, NY NTS 36 POSTNATAL BEHAVIORAL SEQUELAE OF PRENATAL EXPOSURE TO 13-CIS RETINOIC ACID. R.P. Jensh, D.M. Kochhar, M.K. Till and M.B. Eskesen, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA NTS 37 THE EFFECTS OF CHRONIC IN-UTERO EXPOSURE TO NICOTINE ON BEHAVIOR OF GUINEA PIGS (CAVIA PORCELLUS). J.M. Johns, L.J. Peacock, P.A. Walters and D.Q. Estep, East Carolina University, Greenville, NC, and University of Georgia, Athens, GA (Introduced by B.A. McMillen) NTS 38 QUANTITATION OF AGE-RELATED PERFORMANCE OF CHILDREN IN AN OPERANT TEST BATTERY. J.M. Cranmer, T.M. Forrester, M. Maher and M.G. Paule, University of Arkansas for Medical Sciences and Arkansas Children’s Hospital, Little Rock, AR, and National Center for Toxicological Research, Jefferson, AR NTS 39 ASSESSMENT OF ANOMALOUS COMPLEX BRAIN FUNCTION IN A “CHEMICALLY ABUSED CHILD” USING AN OPERANT TEST BATTERY. T.M. Forrester, M. Maher, J.M. Cranmer and M.G. Paule, National Center for Toxicological Research, Jefferson, AR, and University of Arkansas for Medical Sciences and Arkansas Children’s Hospital, Little Rock, AR NTS 40 REPLICATION OF EXPERIMENTS WITHIN LABORATORIES: EXPERIMENTAL DESIGN AND STATISTICAL ANALYSIS. R.R. Holson and B.A. Pearce, National Center for Toxicological Research, Jefferson, AR NTS 41 A SPATIAL DISCRIMINATED WATERMAZE TASK AS AN EVALUATION OF LEARNING AND RETENTION IN DEVELOPMENTAL NEUROTOXICITY TEST BATTERIES: HISTORICAL CONTROL DATA. E.A. Lochry, J.A. Foss and M.S. Christian, Argus Research Laboratories, Inc., Horsham, PA NTS 42 POSTNATAL EXPOSURE TO NEWCASTLE DISEASE VIRUS ALTERS ENDOCRINE DEVELOPMENT. M.P. O’Grady and N.R.S. Hall, University of South Florida, Tampa, FL (Introduced by R.E. Butcher) 9:45
POSTER DISCUSSION-Esquimalt (C) Co-Chairs: L.P. Spear and E.P. Riley
SUNDAY, JUNE 10 SYMPOSIUM V: DETECTING MORPHOLOGICAL CORRELATES OF DEVELOPMENTAL INJURIES TO THE CNS Organizer and Moderator: P.A. Rodier Esquimalt (C), 8:OO-9:45 8:OO
NTS 43 DETECTING MORPHOLOGICAL CHANGES AFTER PRENATAL EXPOSURE TO ETHANOL. J.R. West and C.R. Goodlett, University of Iowa, Iowa City, IA
8:30
NTS 44 DETECTING CHANGES IN CELL NUMBER, SIZE, AND DENDRITIC EXTENT: MORPHOMETRIC AND ALTERNATIVE QUANTITATIVE METHODS. D.G. Flood and P.C. Coleman, University of Rochester, Rochester, NY
9:oo
NTS 45 DETECTING MORPHOLOGICAL CHANGES BY QUANTIFICATION OF CELL PRODUCTS. J.P. O’Callaghan, US Environmental Protection Agency, Research Triangle Park, NC
9:30
DISCUSSION
9:45
BREAK
NEUROBEHAVIORAL TERATOLOGY SOCIETY PROGRAM
609
PLATFORM SESSION Chair: C.D. Driscoll Esquimalt (C), 1O:OO-12:OO
1o:oo
NTS 46 DETERMINANTS OF RAT BEHAVIOR: ANIMAL HUSBANDRY TECHNIQUES, CAGING CONDITIONS, AND INTER- AND EXTRA APPARATUS ODOR CUES INFLUENCE PERFORMANCE ON COMMON BEHAVIORAL PARADIGMS. R.R. Holson, National Center for Toxicological Research, Jefferson, AR
10:15
NTS 47 A RODENT MODEL OF MENTAL RETARDATION: ACCUMULATED LEARNING. B.J. Strupp, D.A. Levitsky, M. Bunsey and K. Hamberger, Cornell University, Ithaca, NY
10:30
NTS 48 COCAINE EXPOSURE IN UTERO ALTERS RAT DEVELOPMENT AND BEHAVIOR. B.A. McMillen, J.M. Johns, and L.W. Means, East Carolina University, Greenville, NC
10:45
NTS 49 PRENATAL VALPROIC ACID (VPA): NEUROBEHAVIORAL AND PTZ-INDUCED SEIZURE DEVELOPMENT. S.K. Sobrian, N.L. Robinson and L.E. Burton, Howard University College of Medicine, Washington, DC
11:oo
NTS 50 DISREGULATION OF THE HYPOTHALAMIC-PITUITARY-GONADAL (HPG) AXIS IN ADULT MALE AND FEMALE RATS EXPOSED TO LEAD DURING THE LAST WEEK OF GESTATION. R.F. McGivern and R.Z. Sokol, HarboriUCLA Medical Center, Torrance, CA
11:15
NTS 51 PRE- AND POSTSYNAPTIC SEPTOHIPPOCAMPAL CHOLINERGIC BIOCHEMISTRY AFTER EARLY EXPOSURE TO PHENOBARBITAL. J. Yanai, M.E. Newman, C.G. Pick, Y. Rogel-Fuchs, D. Trombka and E.A. Zahalka, Hebrew University, Hadassah Medical School and Jerusalem Mental Health Center, Jerusalem, Israel
11:30
NTS 52 EFFECTS OF MODERATE PRENATAL ALCOHOL EXPOSURE ON TEACHER-RATED CLASSROOM BEHAVIOR AND ACADEMIC PERFORMANCE IN CHILDREN AGED 11 YEARS. H. Carmichael Olson, A.P. Streissguth and H. Barr, University of Washington, Seattle, WA
11:45
NTS 53 THREE AND FOUR YEAR NEUROBEHAVIORAL ASSESSMENT OF CHILDREN EXPOSED PRENATALLY TO CIGARETTES AND MARIHUANA. P.A. Fried and B. Watkinson, Carleton University, Ottawa, Ontario, Canada
12:oo
MEETING ADJOURNED
1990 Neurobehavioral Teratology Society Author Index Acuff, K.D., NTS15, 16, 17 Adams, J., NTS11, 12 Ali, S.F., NTS19 Barr, H., NTS52 Battaglia, B., N T S l l Bilitzke, P., NTS22 Booze, R.M., NTS4 Broxup, B., NTS32 Buelke-Sam, J., NTS29, 30 Burton, L.E., NTS49 Bunsey, M., NTS47 Byrd, R.A., NTS29 Campbell, B.A., NTS5 Carmichael Olson, H., NTS52 Carughi, A,, NTS28 Christian, M.S., NTS41 Church, M.W., NTS21, 22 Coleman, P.C., NTS44 Cranmer, J.M., NTS38, 39 Delia, S., NTS23 Dumas, R., NTS23 Eskesen, M.B., NTS36 Estep, D.Q., NTS37 Fagen, J.W., NTS8 Flood, D.G., NTS44 Forrester, T.M., NTS38, 39 Foss, J.A., NTS41 Francis, E.Z., NTSlO Frambes, N.A., NTS19 Fried, P.A., NTS53 Gentry, G.D., NTS25 Gershwin, M.E., NTS3l Golub, M.S., NTS31 Goodlett, C.R., NTS43 Gray, J.K., NTS26 Hall, N.R.S., NTS42
Hamberger, K., NTS47 Hanasono, G.K., NTS30 Hannigan, J.H., NTS27 Hayne, H., NTS5 Helton, D.R., NTS30 Heyser, C.J., NTS18 Hoffman, H., NTS6 Holmes, L.B., N T S l l Holson, R.R., NTSZO, 40, 46 Holt, J.A., NTS30 Jensh, R.P., NTS36 Jersey, R., NTS14 Johns, J.M., NTS37, 48 Johnson, J.A., NTS29 Joseph, J.A., NTSB Keen, C.L., NTS31 Kochhar, D.M., NTS36 Kuhn, C.M., NTS33 Lammer, E.J., N T S l l Levitsky, D.A., NTS47 Lochry, E.A., NTS41 Mactutus, C.F., NTS9 Maher, M., NTS38, 39 Martin, J.C., NTSl Means, L.W., NTS48 McGivern, R.F., NTS50 McMillen, B.A., NTS48 Middaugh, L.D., NTS24, 25 Minck, D.R., NTS15, 16, 17 Newman, M.E., NTS51 O’Callaghan, J.P., NTS45 O’Grady, M.P., NTS42 Overbeck, G.W., NTS2l Owen, N.V., NTS29 Paule, M.G., NTS38, 39 Peacock, L.J., NTS37
610
Pearce, B.A., NTS40 Petit, T.L., NTS3 Pick, C.G., NTS51 Pilati, M.L., NTS27 Pizzi, W.J., NTS14 Rabe, A,, NTS23 Rice, S.A., NTS28 Richardson, R., NTS5 Robinson, K.J., NTS32 Robinson, N.L., NTS49 Rogel-Fuchs, Y., NTS51 Roth, G.S., NTSB Scalzo, F.M., NTS19, 20 Serra, M.T., NTS28 Sersen, E.A., NTS23 Singh, J., NTS34 Sobrian, S.K., NTS49 Sokol, R.Z., NTS50 Spear, L.P., NTS18, 19 Stanton, M.E., NTS33 Streissguth, A.P., NTS26, 52 Strupp, B.J., NTS47 Sullivan, R.M., NTS7 Tempel, A,, NTS35 Till, M.K., NTS36 Tizzano, J.P., NTS29, 30 Trombka, D., NTS51 Vorhees, C.V., NTS13, 15, 16, 17 Walters, P.A., NTS37 Watkinson, B., NTS53 Weisenburger, W.P., NTS15 West, J.R., NTS43 Yanai, J., NTS51 Zahalka, E.A., NTS51
NEUROBEHAVIORAL TERATOLOGY SOClETY FOURTEENTH ANNUAL MEETING JUNE 7-10, 1990 VICTORIA CONFERENCE CENTRE VICTORIA, BRITISH COLUMBIA, CANADA Program and Abstracts NEUROBEHAVIORAL TERATOLOGY SOCIETY OFFICERS 1989-1990 (Expiration of Term) W. PIZZI, President-Elect C. KIMMEL, President T. BURBACHER, Treasurer S. RICE, Secretary J. MARTIN, Council (1990) D. HUTCHINGS, Liaison Council N. LAUGHLIN, Council (1991) C. RANDALL, Council (1992) R. BUTCHER 1977-79 P. RODIER 1979-80 R. HOAR 1980-81 D. HUTCHINGS 1981-82
PAST PRESIDENTS of the SOCIETY E. RILEY 1982-83 J. ADAMS 1986-87 E. ABEL 1983-84 L. MIDDAUGH 1987-88 C. VORHEES 1984-85 J. BUELKE-SAM 1988-89 R. JENSH 1985-86
FINANCE M. Geyer (1991) B. Strupp (1990)
C. VORHEES, Chairperson (1993) C. KIMMEL (1993) J. ADAMS (1993) E. RILEY (1993)
STANDING COMMITTEES (Expiration of Term) MEMBERSHIP C. Driscoll (1990) S. Schantz (1991) A. Temple (1992)
NOMINATIONS R. Holson (1990) E. Lochry (1991) L. Middaugh (1992)
PUBLICATIONS L. MIDDAUGH (1992) S. RICE (1992) E. LOCHRY (1992)
1989-1990 AD HOC COMMITTEES DEVELOPMENTAL NEUROTOXICITY PROTECTION (AD HOC AWARDS N. Laughlin B.K. Nelson SUBCOMMITTEE 1 S. Rice C. Vorhees T. Burbacher J. Adams R. Holson D. Hutchings R. Butcher R. Smith T. Fico 0 1990 WILEY-LISS, INC.
w. PIZZI (1991) N. LAUGHLIN (1991) E. ABEL (1991)
BY-LAWS S. Rice R. Holson R. Smith
604
NEUROBEHAVIORAL TERATOLOGY SOCIETY PROGRAM
The Neurobehavioral Teratology Society would like to acknowledge and thank the following companies for their financial support of the 1990 annual meeting. ABBOTT LABORATORIES ARGUS RESEARCH LABORATORIES BRISTOL-MYERS COMPANY HOFFMANN-LAROCHE, INC. R.W. JOHNSON PHARMACEUTICAL RES. INST.
MARCH OF DIMES PROCTOR & GAMBLE COMPANY SAN DIEGO INSTRUMENTS SMITH KLINE BEECHAM
PROGRAM THURSDAY, JUNE 7 9.00
A M -6:OO P M
REGISTRATION-Plaza
Prefunction
3:OO-4:00
PM
PUBLICATIONS COMMITTEE-Metchosin (HI
4:OO-5:00
PM
DEVELOPMENTAL NEUROTOXICITY PROTECTION COMMITTEEMetchosin (H)
6:30-8:OO
PM
PRESIDENTS RECEPTION-Plaza Prefunction
8:OO-1O:OO
PM
COUNCIL MEETING-Sooke (Dj
FRIDAY, JUNE 8 9:40
WELCOME & ANNOUNCEMENTS: C.A. Kimmel-Esquimalt
(C)
SYMPOSIUM I: LONG-TERM EFFECTS OF PERINATAL AND NEONATAL INSULT Organizer and Moderator: R.M. Booze Esquimalt (C), 9:50-11:50 9:50
INTRODUCTION-R.M.
Booze
9:55
NTS 1 LIFETIME EFFECTS OF PERINATAL EXPOSURE TO DRUGS OF ABUSE IN THE RAT MODEL. J.C. Martin, University of Washington, Seattle, WA
10:20
NTS 2 ENVIRONMENTAL INTERVENTIONS AND INFLUENCES IN AGING. J.A. Joseph and G.S. Roth, National Institute on Aging, Baltimore, MD
10:45
NTS 3 MEMORIES, SYNAPSES AND TOXINS: A LIFESPAN APPROACH. T.L. Petit, University of Toronto, Scarborough, Ontario, Canada
11:lO
NTS 4 LONG-TERM EFFECTS OF NEONATAL BRAIN DAMAGE: CROSSSECTIONAL AND LONGITUDINAL STUDIES OF BRAIN PLASTICITY. R.M. Booze, Bowman Gray School of Medicine, Winston-Salem, NC
11:35
DISCUSSION
11:50
LUNCH
NEUROBEHAVIORAL TERATOLOGY SOCIETY PROGRAM
605
SYMPOSIUM 11: EARLY LEARNING AND MEMORYiANIMAL AND HUMAN MODELS Organizer and Moderator: C.F. Mactutus Esquimalt (C), 1:45-4:15 1:45
INTRODUCTION-C.F.
Mactutus
1:50
NTS 5 THE ORIENTING RESPONSE AS A MEASURE OF INFORMATION PROCESSING. R. Richardson, H. Hayne and B.A Campbell, Princeton University, Princeton, N J
2:15
NTS 6 TASTE AVERSION LEARNING IN THE DEVELOPING RAT. H. Hoffman, Knox College, Galesburg, IL
2:40
NTS 7 ASSOCIATIVE LEARNING IN INFANT RATS AND NEONATAL HUMAN INFANTS. R.M. Sullivan, University of Oklahoma, Norman, OK
3:05
NTS 8 LONG-TERM MEMORY IN HUMAN INFANTS AND ITS RELATION TO INTELLIGENCE-TEST PERFORMANCE IN CHILDHOOD. J.W. Fagen, St. John’s University, Jamaica, NY
3:30
NTS 9 ONTOGENY OF SPATIAL LEARNINGIMEMORY. C.F. Mactutus, Bennett College, Greensboro, NC
355
DISCUSSION
4:15
BREAK
4:30-5:00
NTS 10 INVITED ADDRESS: UPDATE ON THE USEPAS DEVELOPMENTAL NEUROTOXICITY STUDY PROTOCOL. E.Z. Francis, US Environmental Protection Agency, Washington, DC-Esquimalt (C)
SATURDAY, JUNE 9 8:30-9:30
INVITED LECTURE: COCAINE: TERATOGEN EPIDEMIC, T.H. Shepard, University of Washington, Seattle, WA; Discussant: Donald E. Hutchings, New York State Psychiatric Institute, New York, NY. Co-sponsored with the Teratology Society Theatre, 8:30-9:30
9:30-1O:OO
BREAK SYMPOSIUM 111: SOCIAL AND ECONOMIC COSTS OF ALCOHOL EXPOSURE DURING PREGNANCY Co-sponsored with the Public Affairs Committee of the Teratology Society Co-chairs: T.A. Marks and E.P. Riley Theatre, 1O:OO -1 2:OO
1o:oo
INTRODUCTION. T.A. Marks, Upjohn Company, Kalamazoo, MI
10:05
FETAL ALCOHOL SYNDROME AMONG NATIVE AMERICANS. J.M. Aase, University of New Mexico School of Medicine, Albuquerque, NM
10:30
NEW UNDERSTANDINGS OF THE FACE AND BRAIN IN FETAL ALCOHOL SYNDROME. S. Clarren, Children’s Hospital and Medical Center, Seattle, WA
10:55
LONG-TERM NEUROBEHAVIORAL EFFECTS OF PRENATAL ALCOHOL EXPOSURE. A.P. Streissguth, University of Washington, Seattle, WA
11:20
EFFECTS OF PRENATAL ALCOHOL EXPOSURE ON GROWTH AND MORPHOLOGY. N.L. Day, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, PA
606
NEUROBEHAVIORAL TERATOLOGY SOCIETY PROGRAM
11:45
DISCUSSION
12:oo
LUNCH SYMPOSIUM IV: ISOTRETINOIN: CLINICAL DEMONSTRATION OF THE PRINCIPLES OF BEHAVIORAL TERATOGENESIS Organizers and Moderators: J . Adams and E.J. Lammer Esquimalt (C), 1:30-3:30
1:30
NTS 11 STUDY DESIGN OF PHASE 2 OF THE LONGITUDINAL STUDY OF INFANTS EXPOSED TO ISOTRETINOIN IN UTERO. E.J. Lammer, J . Adams, B. Battaglia and L.B. Holmes, California Birth Defects Monitoring Program, Emeryville, CA, and University of Massachusetts and Massachusetts General Hospital, Boston, MA
2:oo
NTS 12 HIGH INCIDENCE OF INTELLECTUAL DEFICITS IN 5 YEAR OLD CHILDREN EXPOSED TO ISOTRETINOIN “IN UTERO.” J. Adams, University of Massachusetts, Boston, MA
2:30
NTS 13 A COMPARISON OF RETINOID TERATOGENESIS IN ANIMALS AND HUMANS. C.V. Vorhees, Children’s Hospital Research Foundation and University of Cincinnati, Cincinnati, OH
3:OO
DISCUSSION
3:15
BREAK
3:30
BUSINESS MEETING-Esquimalt
4:30-8:00
Free Time
(C)
POSTER SESSION AND DISCUSSION Posters should be set up after 1:00 P.M. Saturday and removed by midnight. Posters Attended: 8:OO-9:30 P.M. Saturday, Saanich (A) Refreshments available from 8:OO-9:30 P M . Poster Discussion: 9:45-10:45 P.M. Saturday, Esquimalt (C) NTS 14 DIFFERENTIAL BEHAVIORAL TERATOLOGY FOLLOWING PRENATAL ADMINISTRATION OF SODIUM PHENYTOIN OR PHENYTOIN ACID. W.J. Pizzi and R. Jersey, Northeastern Illinois University, Chicago, IL NTS 15 WORKING MEMORY AND THE OLTON RADIAL-ARM MAZE: EFFECTS OF MATERNAL PHENYLKETONURIA AND PRENATAL PHENYTOIN IN RATS. W.P. Weisenburger, D.R. Minck, K.D. Acuff and C.V. Vorhees, Children’s Hospital Research Foundation, Cincinnati, OH, and International Research and Development Corporation, Mattawan, MI NTS 16 STRUCTURE-ACTIVITY BEHAVIORAL TERATOGENIC ANALYSIS OF THE HYDANTOIN ANTICONVULSANTS. D.R. Minck, K.D. Acuff and C.V. Vorhees. Children’s Hospital Research Foundation and University of Cincinnati, Cincinnati, OH NTS 17 A NEW METHOD FOR EVALUATING THE AIR-RIGHTING REFLEX IN DEVELOPING RATS. K.D. Acuff, D.R. Minck and C.V. Vorhees. Chidren’s Hospital Research Foundation and University of Cincinnati, Cincinnati, OH NTS 18 EFFECTS O F SUBCUTANEOUS ADMINISTRATION OF COCAINE DURING GESTATION ON MATERNAL AND OFFSPRING BODY WEIGHTS: THREE YEARS WORTH OF DATA. C.J. Heyser and L.P. Spear, SUNY-Binghamton, Binghamton, NY
NEUROBEHAVIORAL TERATOLOGY SOCIETY PROGRAM
607
NTS 19 PRENATAL EXPOSURE OF COCAINE IN RATS PRODUCES SIGNIFICANT ALTERATIONS IN STRIATAL DOPAMINE (D2) RECEPTOR BINDING IN OFFSPRING. S.F. Ali, F.M. Scalzo, N.A. Frambes and L.P. Spear. National Center for Toxicological Research, Jefferson, AR, and SUNY-Binghamton, Binghamton, NY NTS 20 THE ONTOGENY OF BEHAVIORAL SENSITIZATION AND TOLERANCE TO PHENCYCLIDINE (PCP) AND COCAINE. F.M. Scalzo and R.R. Holson. National Center for Toxicological Research, Jefferson, AR NTS 21 PRENATAL COCAINE EXPOSURE IN THE RAT: DEVELOPMENTAL DELAY IN THE BRAINSTEM AUDITORY EVOKED POTENTIAL. M.W. Church and G.W. Overbeck, Wayne State University School of Medicine, Detroit, MI NTS 22 EFFECTS O F PRENATAL ALCOHOL AND COCAINE EXPOSURES ON STRESS ADAPTATION. P. Bilitzke and M.W. Church, Wayne State University School of Medicine, Detroit, MI NTS 23 EXPOSURE TO A SINGLE LARGE ORAL DOSE OF ETHANOL DURING EARLY GESTATION ALTERS SPONTANEOUS ACTIVITY IN WEANLING C57 MICE. R. Dumas, A. Rabe, E.A. Sersen and S. Delia, New York State Institute for Basic Research in Developmental Disabilities, Staten Island, NY NTS 24 IN UTERO ETHANOL EFFECTS ON GROWTH AND ON FOOD-REINFORCED BEHAVIOR: DEPENDENCE ON GESTATIONAL STAGE OF EXPOSURE. L.D. Middaugh, Medical University of South Carolina, Charleston, SC NTS 25 EFFECT O F PRENATAL ETHANOL EXPOSURE ON NEONATAL BEHAVIOR. G.D. Gentry and L.D. Middaugh, College of Charleston and Medical University of South Carolina, Charleston, SC NTS 26 MEMORY DEFICITS AND LIFE ADJUSTMENT IN ADULTS WITH FETAL ALCOHOL SYNDROME. J.K. Gray and A.P. Streissguth, University of Washington Medical School, Seattle, WA NTS 27 EFFECTS OF CHRONIC AMPHETAMINE ON WEIGHT GAIN AND ACTIVITY OF FEMALE RATS EXPOSED PRENATALLY TO ETHANOL. M.L. Pilati and J.H. Hannigan, SUNYAlbany, Albany, NY NTS 28 STARTLE HYPERREACTIVITY FOLLOWING REPEATED PRENATAL N20 EXPOSURE IN SD RATS. S.A. Rice, A. Carughi and M.T. Serra, Stanford University and VA Medical Center, Palo Alto, CA NTS 29 DEVELOPMENTAL TOXICOLOGY OF THE DOPAMINE AGONIST PERGOLIDE MESYLATE IN CD-1 MICE. J . Buelke-Sam, R.A. Byrd, J.A. Johnson, J.P. Tizzano and N.V. Owen, Eli Lilly & Co., Greenfield, IN NTS 30 DEVELOPMENTAL TOXICOLOGY STUDIES OF PICENADOL ADMINISTERED IN THE DIET TO RATS. J.P. Tizzano, J.A. Hoyt, G.K. Hanasono, D.R. Helton and J . Buelke-Sam, Eli Lilly & Co., Greenfield, IN NTS 31 SELECTIVE NEURODEVELOPMENTAL EFFECTS OF EXCESS DIETARY ALUMINUM (AL) IN MICE. M.S. Golub, C.L. Keen and M.E. Gershwin, University of California, Davis, Davis, CA NTS 32 EFFECTS OF PRENATAL METHYL MERCURY EXPOSURE UPON BEHAVIOR AND NEUROPATHOLOGY. K.J. Robinson and B. Broxup, Bio-Research Laboratories, Ltd., Senneville, Quebec, Canada (Introduced by G.E. Dearlove) NTS 33 CORTICOSTERONE HYPERSECRETION IN PREWEANLING RATS EXPOSED NEONATALLY TO TRIMETHYLTIN (TMT). M.E. Stanton and C.M. Kuhn, U.S. Environmental Protection Agency, Research Triangle Park, and Duke University, Durham, NC (Introduced by C.A. Kimmel) NTS 34 ASSOCIATION OF NEONATAL REFLEX DEVELOPMENT WITH BIRTH WEIGHT DEFICITS. J. Singh, Stillman College, Tuscaloosa, AL
608
NEUROBEHAVIORAL TERATOLOGY SOCIETY PROGRAM
NTS 35 MORPHINE-INDUCED CHANGES IN PREPROENKEPHALIN MRNA IN NEONATAL RAT BRAIN. A. Tempel, Hillside HospitaliLIJMC, Glen Oaks, NY NTS 36 POSTNATAL BEHAVIORAL SEQUELAE OF PRENATAL EXPOSURE TO 13-CIS RETINOIC ACID. R.P. Jensh, D.M. Kochhar, M.K. Till and M.B. Eskesen, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA NTS 37 THE EFFECTS OF CHRONIC IN-UTERO EXPOSURE TO NICOTINE ON BEHAVIOR OF GUINEA PIGS (CAVIA PORCELLUS). J.M. Johns, L.J. Peacock, P.A. Walters and D.Q. Estep, East Carolina University, Greenville, NC, and University of Georgia, Athens, GA (Introduced by B.A. McMillen) NTS 38 QUANTITATION OF AGE-RELATED PERFORMANCE OF CHILDREN IN AN OPERANT TEST BATTERY. J.M. Cranmer, T.M. Forrester, M. Maher and M.G. Paule, University of Arkansas for Medical Sciences and Arkansas Children’s Hospital, Little Rock, AR, and National Center for Toxicological Research, Jefferson, AR NTS 39 ASSESSMENT OF ANOMALOUS COMPLEX BRAIN FUNCTION IN A “CHEMICALLY ABUSED CHILD” USING AN OPERANT TEST BATTERY. T.M. Forrester, M. Maher, J.M. Cranmer and M.G. Paule, National Center for Toxicological Research, Jefferson, AR, and University of Arkansas for Medical Sciences and Arkansas Children’s Hospital, Little Rock, AR NTS 40 REPLICATION OF EXPERIMENTS WITHIN LABORATORIES: EXPERIMENTAL DESIGN AND STATISTICAL ANALYSIS. R.R. Holson and B.A. Pearce, National Center for Toxicological Research, Jefferson, AR NTS 41 A SPATIAL DISCRIMINATED WATERMAZE TASK AS AN EVALUATION OF LEARNING AND RETENTION IN DEVELOPMENTAL NEUROTOXICITY TEST BATTERIES: HISTORICAL CONTROL DATA. E.A. Lochry, J.A. Foss and M.S. Christian, Argus Research Laboratories, Inc., Horsham, PA NTS 42 POSTNATAL EXPOSURE TO NEWCASTLE DISEASE VIRUS ALTERS ENDOCRINE DEVELOPMENT. M.P. O’Grady and N.R.S. Hall, University of South Florida, Tampa, FL (Introduced by R.E. Butcher) 9:45
POSTER DISCUSSION-Esquimalt (C) Co-Chairs: L.P. Spear and E.P. Riley
SUNDAY, JUNE 10 SYMPOSIUM V: DETECTING MORPHOLOGICAL CORRELATES OF DEVELOPMENTAL INJURIES TO THE CNS Organizer and Moderator: P.A. Rodier Esquimalt (C), 8:OO-9:45 8:OO
NTS 43 DETECTING MORPHOLOGICAL CHANGES AFTER PRENATAL EXPOSURE TO ETHANOL. J.R. West and C.R. Goodlett, University of Iowa, Iowa City, IA
8:30
NTS 44 DETECTING CHANGES IN CELL NUMBER, SIZE, AND DENDRITIC EXTENT: MORPHOMETRIC AND ALTERNATIVE QUANTITATIVE METHODS. D.G. Flood and P.C. Coleman, University of Rochester, Rochester, NY
9:oo
NTS 45 DETECTING MORPHOLOGICAL CHANGES BY QUANTIFICATION OF CELL PRODUCTS. J.P. O’Callaghan, US Environmental Protection Agency, Research Triangle Park, NC
9:30
DISCUSSION
9:45
BREAK
NEUROBEHAVIORAL TERATOLOGY SOCIETY PROGRAM
609
PLATFORM SESSION Chair: C.D. Driscoll Esquimalt (C), 1O:OO-12:OO
1o:oo
NTS 46 DETERMINANTS OF RAT BEHAVIOR: ANIMAL HUSBANDRY TECHNIQUES, CAGING CONDITIONS, AND INTER- AND EXTRA APPARATUS ODOR CUES INFLUENCE PERFORMANCE ON COMMON BEHAVIORAL PARADIGMS. R.R. Holson, National Center for Toxicological Research, Jefferson, AR
10:15
NTS 47 A RODENT MODEL OF MENTAL RETARDATION: ACCUMULATED LEARNING. B.J. Strupp, D.A. Levitsky, M. Bunsey and K. Hamberger, Cornell University, Ithaca, NY
10:30
NTS 48 COCAINE EXPOSURE IN UTERO ALTERS RAT DEVELOPMENT AND BEHAVIOR. B.A. McMillen, J.M. Johns, and L.W. Means, East Carolina University, Greenville, NC
10:45
NTS 49 PRENATAL VALPROIC ACID (VPA): NEUROBEHAVIORAL AND PTZ-INDUCED SEIZURE DEVELOPMENT. S.K. Sobrian, N.L. Robinson and L.E. Burton, Howard University College of Medicine, Washington, DC
11:oo
NTS 50 DISREGULATION OF THE HYPOTHALAMIC-PITUITARY-GONADAL (HPG) AXIS IN ADULT MALE AND FEMALE RATS EXPOSED TO LEAD DURING THE LAST WEEK OF GESTATION. R.F. McGivern and R.Z. Sokol, HarboriUCLA Medical Center, Torrance, CA
11:15
NTS 51 PRE- AND POSTSYNAPTIC SEPTOHIPPOCAMPAL CHOLINERGIC BIOCHEMISTRY AFTER EARLY EXPOSURE TO PHENOBARBITAL. J. Yanai, M.E. Newman, C.G. Pick, Y. Rogel-Fuchs, D. Trombka and E.A. Zahalka, Hebrew University, Hadassah Medical School and Jerusalem Mental Health Center, Jerusalem, Israel
11:30
NTS 52 EFFECTS OF MODERATE PRENATAL ALCOHOL EXPOSURE ON TEACHER-RATED CLASSROOM BEHAVIOR AND ACADEMIC PERFORMANCE IN CHILDREN AGED 11 YEARS. H. Carmichael Olson, A.P. Streissguth and H. Barr, University of Washington, Seattle, WA
11:45
NTS 53 THREE AND FOUR YEAR NEUROBEHAVIORAL ASSESSMENT OF CHILDREN EXPOSED PRENATALLY TO CIGARETTES AND MARIHUANA. P.A. Fried and B. Watkinson, Carleton University, Ottawa, Ontario, Canada
12:oo
MEETING ADJOURNED
1990 Neurobehavioral Teratology Society Author Index Acuff, K.D., NTS15, 16, 17 Adams, J., NTS11, 12 Ali, S.F., NTS19 Barr, H., NTS52 Battaglia, B., N T S l l Bilitzke, P., NTS22 Booze, R.M., NTS4 Broxup, B., NTS32 Buelke-Sam, J., NTS29, 30 Burton, L.E., NTS49 Bunsey, M., NTS47 Byrd, R.A., NTS29 Campbell, B.A., NTS5 Carmichael Olson, H., NTS52 Carughi, A,, NTS28 Christian, M.S., NTS41 Church, M.W., NTS21, 22 Coleman, P.C., NTS44 Cranmer, J.M., NTS38, 39 Delia, S., NTS23 Dumas, R., NTS23 Eskesen, M.B., NTS36 Estep, D.Q., NTS37 Fagen, J.W., NTS8 Flood, D.G., NTS44 Forrester, T.M., NTS38, 39 Foss, J.A., NTS41 Francis, E.Z., NTSlO Frambes, N.A., NTS19 Fried, P.A., NTS53 Gentry, G.D., NTS25 Gershwin, M.E., NTS3l Golub, M.S., NTS31 Goodlett, C.R., NTS43 Gray, J.K., NTS26 Hall, N.R.S., NTS42
Hamberger, K., NTS47 Hanasono, G.K., NTS30 Hannigan, J.H., NTS27 Hayne, H., NTS5 Helton, D.R., NTS30 Heyser, C.J., NTS18 Hoffman, H., NTS6 Holmes, L.B., N T S l l Holson, R.R., NTSZO, 40, 46 Holt, J.A., NTS30 Jensh, R.P., NTS36 Jersey, R., NTS14 Johns, J.M., NTS37, 48 Johnson, J.A., NTS29 Joseph, J.A., NTSB Keen, C.L., NTS31 Kochhar, D.M., NTS36 Kuhn, C.M., NTS33 Lammer, E.J., N T S l l Levitsky, D.A., NTS47 Lochry, E.A., NTS41 Mactutus, C.F., NTS9 Maher, M., NTS38, 39 Martin, J.C., NTSl Means, L.W., NTS48 McGivern, R.F., NTS50 McMillen, B.A., NTS48 Middaugh, L.D., NTS24, 25 Minck, D.R., NTS15, 16, 17 Newman, M.E., NTS51 O’Callaghan, J.P., NTS45 O’Grady, M.P., NTS42 Overbeck, G.W., NTS2l Owen, N.V., NTS29 Paule, M.G., NTS38, 39 Peacock, L.J., NTS37
610
Pearce, B.A., NTS40 Petit, T.L., NTS3 Pick, C.G., NTS51 Pilati, M.L., NTS27 Pizzi, W.J., NTS14 Rabe, A,, NTS23 Rice, S.A., NTS28 Richardson, R., NTS5 Robinson, K.J., NTS32 Robinson, N.L., NTS49 Rogel-Fuchs, Y., NTS51 Roth, G.S., NTSB Scalzo, F.M., NTS19, 20 Serra, M.T., NTS28 Sersen, E.A., NTS23 Singh, J., NTS34 Sobrian, S.K., NTS49 Sokol, R.Z., NTS50 Spear, L.P., NTS18, 19 Stanton, M.E., NTS33 Streissguth, A.P., NTS26, 52 Strupp, B.J., NTS47 Sullivan, R.M., NTS7 Tempel, A,, NTS35 Till, M.K., NTS36 Tizzano, J.P., NTS29, 30 Trombka, D., NTS51 Vorhees, C.V., NTS13, 15, 16, 17 Walters, P.A., NTS37 Watkinson, B., NTS53 Weisenburger, W.P., NTS15 West, J.R., NTS43 Yanai, J., NTS51 Zahalka, E.A., NTS51
