Biochemical Society Transactions
Multiple histamine receptors: properties and functional characteristics
I22
Stephen J. Hill Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham NG7 ZUH, U.K.
Introduction I Iistamine receptors have been divided into three major subtypes, H I , €I2 and H3, on the basis of quantitative studies in vitro in isolated tissues and brain preparations [ 11. Histamine HI-receptors are coupled to inositol phospholipid hydrolysis and mediate functional responses in many tissues (e.g. smooth muscle contraction. increased vascular permeability, hormone release and cerebral glycogenolysis) as a consequence of intracellular calcium mobilization and calcium influx [ 1 1. I listamine HLreceptors are positively coupled to adenylate cyclase via a
Multiple histamine receptors: properties and functional characteristics
I22
Stephen J. Hill Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham NG7 ZUH, U.K.
Introduction I Iistamine receptors have been divided into three major subtypes, H I , €I2 and H3, on the basis of quantitative studies in vitro in isolated tissues and brain preparations [ 11. Histamine HI-receptors are coupled to inositol phospholipid hydrolysis and mediate functional responses in many tissues (e.g. smooth muscle contraction. increased vascular permeability, hormone release and cerebral glycogenolysis) as a consequence of intracellular calcium mobilization and calcium influx [ 1 1. I listamine HLreceptors are positively coupled to adenylate cyclase via a
