Journal of Chromatography B journal homepage: www.elsevier.com/locate/chromb
Evaluation of plasma microsampling for dried plasma spots (DPS) in quantitative LC-MS/MS bioanalysis using ritonavir as a model compound Wenkui Li ∗ , John Doherty, Sarah Favara, Christopher Breen, Jimmy Flarakos, Francis L.S. Tse Department of Drug Metabolism and Pharmacokinetics, Novartis Institutes for Biomedical Research, One Health Plaza, East Hanover, NJ 07936, USA
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Article history: Received 16 February 2015 Accepted 25 March 2015 Available online 3 April 2015 Keywords: Dried plasma spot (DPS) sampling Plasma microsampling Dried matrix card LC-MS/MS Ritonavir Quantitative bioanalysis
1. Introduction A plasma microsampling technique is currently on the horizon for quantitative bioanalysis in support of drug development [1–3]. Briefly,
MS bioanalysis using ritonavir as a model compound.
Quantitative bioanalysis of dried plasma spots (DPS) is not subject to the impact of hematocrit and sample non-homogeneity that are often encountered ...