RESEARCH ARTICLE

Moxibustion for pain relief in patients with primary dysmenorrhea: A randomized controlled trial Mingxiao Yang1☯, Xiangzhu Chen2☯, Linna Bo3, Lixing Lao4, Jiao Chen1, Siyi Yu1, Zheng Yu2, Hongzhi Tang1, Ling Yi5, Xi Wu1, Jie Yang1*, Fanrong Liang1*

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1 School of Acupuncture and moxibustion, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China, 2 Pixian Hospital of Traditional Chinese Medicine, Chengdu, Sichuan, China, 3 Rentong Clinics of Traditional Chinese Medicine, Chengdu, Sichuan, China, 4 School of Chinese Medicine, The University of Hong Kong, Hong Kong, 5 Medical Center and Hospital of Qionglai, Chengdu, Sichuan, China ☯ These authors contributed equally to this work. * [email protected] (JY); [email protected] (FRL)

Abstract OPEN ACCESS Citation: Yang M, Chen X, Bo L, Lao L, Chen J, Yu S, et al. (2017) Moxibustion for pain relief in patients with primary dysmenorrhea: A randomized controlled trial. PLoS ONE 12(2): e0170952. doi:10.1371/journal.pone.0170952 Editor: Cornelis B Lambalk, VU medisch centrum, NETHERLANDS Received: February 22, 2016 Accepted: January 13, 2017 Published: February 7, 2017 Copyright: © 2017 Yang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data availability statement: All relevant data are within the paper and its Supporting Information files. Funding: This study was financially supported by the National Basic Research Program, China 973 program, No. 2012CB518501 and the “2011 Innovation Center” Program from the Education Department of Sichuan province, grants from the National Natural Science Foundation of China (No. 81590950, 81574089, 81303060) and the Chinese Scholarship Council. The funders had no role in

Background Though moxibustion is frequently used to treat primary dysmenorrhea in China, relevant evidence supporting its effectiveness is still scanty.

Methods This study was a pragmatic randomized, conventional drug controlled, open-labeled clinical trial. After initial screen, 152 eligible participants were averagely randomized to receive two different treatment strategies: Moxibustion and conventional drugs. Participants and practitioners were not blinded in this study. The duration of each treatment was 3 months. The primary outcome was pain relief measured by the Visual Analogue Scale. The menstrual pain severity was recorded in a menstrual pain diary.

Results 152 eligible patients were included but only 133 of them eventually completed the whole treatment course. The results showed that the menstrual pain intensity in experimental group and control group was reduced from 6.38±1.28 and 6.41±1.29, respectively, at baseline, to 2.54±1.41 and 2.47±1.29 after treatment. The pain reduction was not significantly different between these two groups (P = 0.76), however; the pain intensity was significantly reduced relative to baseline for each group (P

Moxibustion for pain relief in patients with primary dysmenorrhea: A randomized controlled trial.

Though moxibustion is frequently used to treat primary dysmenorrhea in China, relevant evidence supporting its effectiveness is still scanty...
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