Diabetologia DOI 10.1007/s00125-014-3271-3

ARTICLE

Molecular and pathological studies in the posterior interosseous nerve of diabetic and non-diabetic patients with carpal tunnel syndrome Moaz A. Mojaddidi & Mohammed S. Ahmed & Razwan Ali & Maria Jeziorska & Ahmed Al-Sunni & Niels O. B. Thomsen & Lars B. Dahlin & Rayaz A. Malik

Received: 13 February 2014 / Accepted: 22 April 2014 # Springer-Verlag Berlin Heidelberg 2014

Abstract Aims/hypothesis We sought to establish the molecular and pathological changes predisposing diabetic and non-diabetic patients to the development of carpal tunnel syndrome (CTS). Methods The posterior interosseous nerve (PIN) was biopsied in 25 diabetic and 19 non-diabetic patients undergoing carpal tunnel decompression for CTS. Detailed morphometric and immunohistological analyses were performed in the nerve biopsy. Results In diabetic patients median nerve distal motor latency was prolonged ( p < 0.05 vs non-diabetic patients), PIN myelinated fibre density ( p < 0.05), fibre area ( p

Molecular and pathological studies in the posterior interosseous nerve of diabetic and non-diabetic patients with carpal tunnel syndrome.

We sought to establish the molecular and pathological changes predisposing diabetic and non-diabetic patients to the development of carpal tunnel synd...
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