Modelling the impact and cost-effectiveness of combination prevention amongst HIV serodiscordant couples in Nigeria Kate M. Mitchella, Aure´lia Le´pinea, Fern Terris-Prestholta, Kwasi Torpeyb, Hadiza Khamofub, Morenike O. Folayanc, Jonah Musad, James Anenihe, Atiene S. Sagayd, Emmanuel Alhassane, John Idokoe and Peter Vickermanf Objective: To estimate the impact and cost-effectiveness of treatment as prevention (TasP), pre-exposure prophylaxis (PrEP) and condom promotion for serodiscordant couples in Nigeria. Design: Mathematical and cost modelling. Methods: A deterministic model of HIV-1 transmission within a cohort of serodiscordant couples and to/from external partners was parameterized using data from Nigeria and other African settings. The impact and cost-effectiveness were estimated for condom promotion, PrEP and/or TasP, compared with a baseline where antiretroviral therapy (ART) was offered according to 2010 national guidelines (CD4þ