Mitochondrial DNA Content as Risk Factor for Bladder Cancer and its Association with Mitochondrial DNA Polymorphisms
Stephen B. Williams1,2, Yuanqing Ye1, Maosheng Huang1, David W. Chang1, Ashish M. Kamat2, Xia Pu1, Colin P. Dinney2, Xifeng Wu1
From the Departments of Epidemiology1 and Urology2, The University of Texas MD Anderson Cancer Center, Houston, TX2
Corresponding author: Xifeng Wu, MD Department of Epidemiology, MD Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030 Phone: 713-745-2485 Fax: 713-792-4657 Email: [email protected]
Abstract word count: 246 Manuscript word count: 3676 Running Title: Mitochondrial DNA Content and Risk of Bladder Cancer Keywords: Mitochondria; DNA; Risk; mtDNA content; Polymorphisms; Bladder Cancer Acknowledgement: This work is supported by U01 CA 127615 (X. Wu) P50 CA 91846 (X. Wu and C.P. Dinney), Centre for Translational and Public Health Genomics at MD Anderson Cancer Centre (X. Wu) Conflict of interest: The authors declare no conflicts of interest
ABSTRACT Mitochondrial DNA (mtDNA) content has been shown to be associated with cancer susceptibility. We identified 926 bladder cancer patients and compared these to 926 healthy-controls frequency matched on age, gender, and ethnicity. Patients diagnosed with bladder cancer had significantly decreased mtDNA content when compared to control subjects (median: 0.98 vs. 1.04, p
Stephen B. Williams1,2, Yuanqing Ye1, Maosheng Huang1, David W. Chang1, Ashish M. Kamat2, Xia Pu1, Colin P. Dinney2, Xifeng Wu1
From the Departments of Epidemiology1 and Urology2, The University of Texas MD Anderson Cancer Center, Houston, TX2
Corresponding author: Xifeng Wu, MD Department of Epidemiology, MD Anderson Cancer Center 1515 Holcombe Boulevard Houston, TX 77030 Phone: 713-745-2485 Fax: 713-792-4657 Email: [email protected]
Abstract word count: 246 Manuscript word count: 3676 Running Title: Mitochondrial DNA Content and Risk of Bladder Cancer Keywords: Mitochondria; DNA; Risk; mtDNA content; Polymorphisms; Bladder Cancer Acknowledgement: This work is supported by U01 CA 127615 (X. Wu) P50 CA 91846 (X. Wu and C.P. Dinney), Centre for Translational and Public Health Genomics at MD Anderson Cancer Centre (X. Wu) Conflict of interest: The authors declare no conflicts of interest
ABSTRACT Mitochondrial DNA (mtDNA) content has been shown to be associated with cancer susceptibility. We identified 926 bladder cancer patients and compared these to 926 healthy-controls frequency matched on age, gender, and ethnicity. Patients diagnosed with bladder cancer had significantly decreased mtDNA content when compared to control subjects (median: 0.98 vs. 1.04, p
