INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 34: 1409-1416, 2014
miR‑886‑3p upregulation in clear cell renal cell carcinoma regulates cell migration, proliferation and apoptosis by targeting PITX1 ZUHU YU1-3*, DUQUN CHEN1-3*, ZHENGMING SU1,2, YIFAN LI1-3, WENSHUI YU1,2, QIANG ZHANG1-3, LIHUA YANG2, CAILING LI2, SHANGQI YANG1,2, LIANGCHAO NI1,2, YAOTING GUI2, ZEBIN MAO4 and YONGQING LAI1,2 1
Department of Urology, Peking University Shenzhen Hospital; 2The Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Shenzhen PKU‑HKUST Medical Center, Shenzhen 518036; 3 Anhui Medical University, Anhui, Hefei 230032; 4Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100083, P.R. China Received March 24, 2014; Accepted August 28, 2014 DOI: 10.3892/ijmm.2014.1923
Abstract. miR‑886‑3p has been discovered to be involved in the oncogenesis, progression and metastasis of several types of human cancer. The aim of the present study was to identify the biological function of miR‑886‑3p in clear cell renal cell carcinoma (ccRCC) and to determine its possible molecular mechanisms. miR‑886‑3p was found to be significantly upregulated in ccRCC tissues (P
miR‑886‑3p upregulation in clear cell renal cell carcinoma regulates cell migration, proliferation and apoptosis by targeting PITX1 ZUHU YU1-3*, DUQUN CHEN1-3*, ZHENGMING SU1,2, YIFAN LI1-3, WENSHUI YU1,2, QIANG ZHANG1-3, LIHUA YANG2, CAILING LI2, SHANGQI YANG1,2, LIANGCHAO NI1,2, YAOTING GUI2, ZEBIN MAO4 and YONGQING LAI1,2 1
Department of Urology, Peking University Shenzhen Hospital; 2The Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Shenzhen PKU‑HKUST Medical Center, Shenzhen 518036; 3 Anhui Medical University, Anhui, Hefei 230032; 4Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100083, P.R. China Received March 24, 2014; Accepted August 28, 2014 DOI: 10.3892/ijmm.2014.1923
Abstract. miR‑886‑3p has been discovered to be involved in the oncogenesis, progression and metastasis of several types of human cancer. The aim of the present study was to identify the biological function of miR‑886‑3p in clear cell renal cell carcinoma (ccRCC) and to determine its possible molecular mechanisms. miR‑886‑3p was found to be significantly upregulated in ccRCC tissues (P
