MINI REVIEW published: 23 August 2016 doi: 10.3389/fphar.2016.00271
miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition Siti A. Sulaiman *, Nurul-Syakima Ab Mutalib and Rahman Jamal UKM Medical Molecular Biology Institute, UKM Medical Centre, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
Edited by: Ruggero De Maria, Catholic University of the Sacred Heart, Italy Reviewed by: Debangshu Samanta, Johns Hopkins University, USA Sergio Marchini, Mario Negri Institute for Pharmacological Research, Italy *Correspondence: Siti A. Sulaiman [email protected] Specialty section: This article was submitted to Cancer Molecular Targets and Therapeutics, a section of the journal Frontiers in Pharmacology Received: 24 June 2016 Accepted: 10 August 2016 Published: 23 August 2016 Citation: Sulaiman SA, Ab Mutalib N-S and Jamal R (2016) miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition. Front. Pharmacol. 7:271. doi: 10.3389/fphar.2016.00271
Among the gynecological malignancies, ovarian cancer is the most fatal due to its high mortality rate. Most of the identified cases are epithelial ovarian cancer (EOC) with five distinct subtypes: high-grade serous carcinoma, low-grade serous carcinoma, mucinous carcinoma, endometrioid carcinoma, and clear-cell carcinoma. Lack of an early diagnostic approach, high incidence of tumor relapse and the heterogenous characteristics between each EOC subtypes contribute to the difficulties in developing precise intervention and therapy for the patients. MicroRNAs (miRNAs) are singlestranded RNAs that have been shown to function as tumor suppressors or oncomiRs. The miR-200 family, especially miR-200c, has been shown to be implicated in the metastasis and invasion of ovarian carcinoma due to its functional regulation of epithelialto-mesenchymal transition (EMT). This mini review is aimed to summarize the recent findings of the miR-200c functional role as well as its validated targets in the metastasis cascade of ovarian cancer, with a focus on EMT regulation. The potential of this miRNA in early diagnosis and its dual expression status are also discussed. Keywords: miR-200c, ovarian cancer, metastasis, regulation, EMT
INTRODUCTION Ovarian cancer has the highest prevalence among the gynecological cancers worldwide with more than 238, 700 newly diagnosed cases and 151, 900 reported deaths per year (Ferlay et al., 2015; Siegel et al., 2016). Among the ovarian malignancies, 90% of the cases are epithelial ovarian cancer (EOC) with five identified subtypes namely, high-grade serous carcinoma (70%), low-grade serous carcinoma (
miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition Siti A. Sulaiman *, Nurul-Syakima Ab Mutalib and Rahman Jamal UKM Medical Molecular Biology Institute, UKM Medical Centre, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
Edited by: Ruggero De Maria, Catholic University of the Sacred Heart, Italy Reviewed by: Debangshu Samanta, Johns Hopkins University, USA Sergio Marchini, Mario Negri Institute for Pharmacological Research, Italy *Correspondence: Siti A. Sulaiman [email protected] Specialty section: This article was submitted to Cancer Molecular Targets and Therapeutics, a section of the journal Frontiers in Pharmacology Received: 24 June 2016 Accepted: 10 August 2016 Published: 23 August 2016 Citation: Sulaiman SA, Ab Mutalib N-S and Jamal R (2016) miR-200c Regulation of Metastases in Ovarian Cancer: Potential Role in Epithelial and Mesenchymal Transition. Front. Pharmacol. 7:271. doi: 10.3389/fphar.2016.00271
Among the gynecological malignancies, ovarian cancer is the most fatal due to its high mortality rate. Most of the identified cases are epithelial ovarian cancer (EOC) with five distinct subtypes: high-grade serous carcinoma, low-grade serous carcinoma, mucinous carcinoma, endometrioid carcinoma, and clear-cell carcinoma. Lack of an early diagnostic approach, high incidence of tumor relapse and the heterogenous characteristics between each EOC subtypes contribute to the difficulties in developing precise intervention and therapy for the patients. MicroRNAs (miRNAs) are singlestranded RNAs that have been shown to function as tumor suppressors or oncomiRs. The miR-200 family, especially miR-200c, has been shown to be implicated in the metastasis and invasion of ovarian carcinoma due to its functional regulation of epithelialto-mesenchymal transition (EMT). This mini review is aimed to summarize the recent findings of the miR-200c functional role as well as its validated targets in the metastasis cascade of ovarian cancer, with a focus on EMT regulation. The potential of this miRNA in early diagnosis and its dual expression status are also discussed. Keywords: miR-200c, ovarian cancer, metastasis, regulation, EMT
INTRODUCTION Ovarian cancer has the highest prevalence among the gynecological cancers worldwide with more than 238, 700 newly diagnosed cases and 151, 900 reported deaths per year (Ferlay et al., 2015; Siegel et al., 2016). Among the ovarian malignancies, 90% of the cases are epithelial ovarian cancer (EOC) with five identified subtypes namely, high-grade serous carcinoma (70%), low-grade serous carcinoma (
