ONCOLOGY LETTERS 13: 1655-1659, 2017
MicroRNA profile of hepatic epithelioid hemangioendothelioma: A case report ASAHIRO MORISHITA1, HISAKAZU IWAMA2, HIROHITO YONEYAMA1, TEPPEI SAKAMOTO1, KOJI FUJITA1, TAKAKO NOMURA1, JOJI TANI1, HISAAKI MIYOSHI1, SHINTARO FUJIHARA1, NORIKO NISHIYAMA1, HIDEKI KOBARA1, HIROHITO MORI1, NAOKI YAMAMOTO3, KEIICHI OKANO3, YASUYUKI SUZUKI3, EMI IBUKI4, REIJI HABA4, TAKASHI HIMOTO5 and TSUTOMU MASAKI1 1
Department of Gastroenterology and Neurology; 2Life Science Research Center; Departments of 3Gastroenterological Surgery and 4Diagnostic Pathology, Faculty of Medicine, Kagawa University, Takamatsu, Kagawa 761‑0793; 5 Department of Medical Technology, Kagawa Prefectural University of Health Sciences, Takamatsu, Kagawa 761‑0123, Japan Received July 28, 2015; Accepted September 1, 2016 DOI: 10.3892/ol.2017.5643
Abstract. A 72‑year‑old female was referred for further evaluation of epigastralgia. Abdominal contrast computed tomography revealed numerous tumors in the two lobes of the liver. Liver biopsy and immunohistochemical staining revealed that the tumor cells were positive for factor VIII‑associated antigen, platelet endothelial cell adhesion molecule 1 and human hematopoietic progenitor cell antigen, concordant with a diagnosis of hepatic epithelioid hemangioendothelioma (HEH). To elucidate the etiology of HEH, particularly the microRNA (miRNA) profiles, tissue samples obtained from normal and tumor tissues were analyzed using a miRNA array system. A total of 14 miRNAs were significantly upregulated and 93 miRNAs were downregulated in the tumor tissues (P
MicroRNA profile of hepatic epithelioid hemangioendothelioma: A case report ASAHIRO MORISHITA1, HISAKAZU IWAMA2, HIROHITO YONEYAMA1, TEPPEI SAKAMOTO1, KOJI FUJITA1, TAKAKO NOMURA1, JOJI TANI1, HISAAKI MIYOSHI1, SHINTARO FUJIHARA1, NORIKO NISHIYAMA1, HIDEKI KOBARA1, HIROHITO MORI1, NAOKI YAMAMOTO3, KEIICHI OKANO3, YASUYUKI SUZUKI3, EMI IBUKI4, REIJI HABA4, TAKASHI HIMOTO5 and TSUTOMU MASAKI1 1
Department of Gastroenterology and Neurology; 2Life Science Research Center; Departments of 3Gastroenterological Surgery and 4Diagnostic Pathology, Faculty of Medicine, Kagawa University, Takamatsu, Kagawa 761‑0793; 5 Department of Medical Technology, Kagawa Prefectural University of Health Sciences, Takamatsu, Kagawa 761‑0123, Japan Received July 28, 2015; Accepted September 1, 2016 DOI: 10.3892/ol.2017.5643
Abstract. A 72‑year‑old female was referred for further evaluation of epigastralgia. Abdominal contrast computed tomography revealed numerous tumors in the two lobes of the liver. Liver biopsy and immunohistochemical staining revealed that the tumor cells were positive for factor VIII‑associated antigen, platelet endothelial cell adhesion molecule 1 and human hematopoietic progenitor cell antigen, concordant with a diagnosis of hepatic epithelioid hemangioendothelioma (HEH). To elucidate the etiology of HEH, particularly the microRNA (miRNA) profiles, tissue samples obtained from normal and tumor tissues were analyzed using a miRNA array system. A total of 14 miRNAs were significantly upregulated and 93 miRNAs were downregulated in the tumor tissues (P
