EXPERIMENTAL AND THERAPEUTIC MEDICINE 14: 173-180, 2017
MicroRNA‑30a‑5p inhibits the proliferation and invasion of gastric cancer cells by targeting insulin‑like growth factor 1 receptor YANG LIU1, YU ZHOU2, XUN GONG3 and CHANGJIE ZHANG1 Departments of 1Rehabilitation, 2Neurosurgery and 3Emergency, Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China Received September 20, 2015; Accepted March 31, 2017 DOI: 10.3892/etm.2017.4477 Abstract. MicroRNAs (miRs) are a class of small non‑coding RNAs of 18‑25 nucleotides in length that serve as key regulators in the development and progression of human cancers. Recently, miR‑30b‑5p, as a member of the miR‑30 family, has been reported to act as a tumor suppressor in gastric cancer. However, the expression and function of miR‑30a‑5p in gastric cancer, as well as the corresponding underlying mechanism, remain unknown. In the present study, it was demonstrated that the expression of miR‑30a‑5p was significantly reduced in gastric cancer tissues (n=43) compared with normal gastric tissues (n=10; P55 Sex Male Female
Number of patients with T1 (from 13 patients)
Number of patients with T2‑T4 (from 30 patients)
4 9
11 19
8 5
17 13
statistical analysis. Differences were analyzed by one‑way analysis of variance and Tukey's post hoc test was performed. The relevance analysis between miR‑30a‑5p expression and IGF‑1R expression was conducted through the Spearman's Correlation Coefficient. P
MicroRNA‑30a‑5p inhibits the proliferation and invasion of gastric cancer cells by targeting insulin‑like growth factor 1 receptor YANG LIU1, YU ZHOU2, XUN GONG3 and CHANGJIE ZHANG1 Departments of 1Rehabilitation, 2Neurosurgery and 3Emergency, Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China Received September 20, 2015; Accepted March 31, 2017 DOI: 10.3892/etm.2017.4477 Abstract. MicroRNAs (miRs) are a class of small non‑coding RNAs of 18‑25 nucleotides in length that serve as key regulators in the development and progression of human cancers. Recently, miR‑30b‑5p, as a member of the miR‑30 family, has been reported to act as a tumor suppressor in gastric cancer. However, the expression and function of miR‑30a‑5p in gastric cancer, as well as the corresponding underlying mechanism, remain unknown. In the present study, it was demonstrated that the expression of miR‑30a‑5p was significantly reduced in gastric cancer tissues (n=43) compared with normal gastric tissues (n=10; P55 Sex Male Female
Number of patients with T1 (from 13 patients)
Number of patients with T2‑T4 (from 30 patients)
4 9
11 19
8 5
17 13
statistical analysis. Differences were analyzed by one‑way analysis of variance and Tukey's post hoc test was performed. The relevance analysis between miR‑30a‑5p expression and IGF‑1R expression was conducted through the Spearman's Correlation Coefficient. P
