Pathol. Oncol. Res. (2015) 21:187–193 DOI 10.1007/s12253-014-9805-7
RESEARCH
Metallothionein 3 Expression in Normal Skin and Malignant Skin Lesions Bartosz Pula & Tadeusz Tazbierski & Aleksandra Zamirska & Bozena Werynska & Andrzej Bieniek & Jacek Szepietowski & Janusz Rys & Piotr Dziegiel & Marzena Podhorska-Okolow
Received: 2 December 2013 / Accepted: 28 May 2014 / Published online: 13 July 2014 # The Author(s) 2014. This article is published with open access at Springerlink.com
Abstract Metallothionein-3 (MT-3) has been shown to be expressed in several malignancies and to have an impact on patients’ survival in breast and urinary bladder cancer cases. However, its expression has not been determined in normal skin or in its malignant lesions. MT-3 expression was studied using immunohistochemistry in 17 cases of normal skin, 18 of actinic keratosis (AK), 39 of squamous cell carcinoma (SCC), and 23 of basal cell carcinoma (BCC). Low MT-3 expression was observed in normal skin epidermis with faint or no expression in the epidermis basal layer. Significantly higher MT-3 expression was noted in AK (P=0.007) and SCC (P
RESEARCH
Metallothionein 3 Expression in Normal Skin and Malignant Skin Lesions Bartosz Pula & Tadeusz Tazbierski & Aleksandra Zamirska & Bozena Werynska & Andrzej Bieniek & Jacek Szepietowski & Janusz Rys & Piotr Dziegiel & Marzena Podhorska-Okolow
Received: 2 December 2013 / Accepted: 28 May 2014 / Published online: 13 July 2014 # The Author(s) 2014. This article is published with open access at Springerlink.com
Abstract Metallothionein-3 (MT-3) has been shown to be expressed in several malignancies and to have an impact on patients’ survival in breast and urinary bladder cancer cases. However, its expression has not been determined in normal skin or in its malignant lesions. MT-3 expression was studied using immunohistochemistry in 17 cases of normal skin, 18 of actinic keratosis (AK), 39 of squamous cell carcinoma (SCC), and 23 of basal cell carcinoma (BCC). Low MT-3 expression was observed in normal skin epidermis with faint or no expression in the epidermis basal layer. Significantly higher MT-3 expression was noted in AK (P=0.007) and SCC (P
