of malarial fever which do not yield readily either to quinine or to arsenic. In such cases he recommends the use of phenocoll. The drug was used by Dr. Cerna in 28 cases, and in 21 the results were good. This result is not ascribed only To the antipyretic qualities of phenocoll but to its antiseptic qualities. It apparently kills the form of Plasmodium malarica which is present in these cases. Phenocoll has many of the theraeffects of phenacetin to which it is closely peutic It is obtained by the interaction of related. phenetidin (para-amido-phenotol) and glycocoll (amido-aceti c acid). The hydrochlorate of phenocoll occur s in the form of a white crystalline powder soluble in water at a temperature of 62?F. (16'6?C.) in the proportion of one to sixsoluble in hot water and teen parts, readily alcohol. It is given in the same doses as phenacetin and has no poisonous properties. Some of Dr. Cerna's patients took as much as 50 grains a day for four or five days without experiencing There are, it apany disagreeable after-effects. pears, cases on which the drug has no effect; seven such cases reported yielded to quinine or arsenic. Antidote to Hydrocyanic Acid.?Druggist's Circular and Chemical Gazette.?" Since hydrocyanic acid is oxidised to oxamide by hydrogen peroxide, experiments were made by P. K'rolil to see if the latter substance ^could be employed as an antidote in the case of hydrocyanic acid poisoning. These experiments are reported as successful, the acid, in larger quantity than the fatal dose, having been administered to dogs and cats, and its effects stayed by means of hydrogen peroxide." cases

Preliminary

Repokt

upon

investiga-

CoNTAGIUM YlVUM of Small-pox.?By the late Stephen C. Martin, m.d.? Boston Medical and Surgical Journal, Dec. 14, 1893.?As the result of careful and prolonged experiments Dr. Martin came to the following conclusions concerning the contagium vivum of small-pox:?(1) That the germ of cow-pox is a bacterium ; (2) that it can be grown upon certain kinds of blood serum; (3) that after an indefinite number of generations of such growth it retains unimpaired its pathogenic tions CONCERNING

THE

properties.

After repeated trials all media for cultivation abandoned except the hardened sterilized serum of bullock's blood. With this at a constant temperature of 37'5?C. experiments were conducted and cultures obtained. These cultures" were not always pure at first. From a colony upon the surface of the blood serum in a tube inoculated with heifer-transmitted cow-pox Dr. Martin started a series of cultures. From both the surface growth and the condensation water of each of these cultures inoculations were made upon calves, and iu every instance a were

Eminent Jfteilicat Sitcrattnje. MEDICINE. The Therapeutic WITH

SPECIAL

uses

REFERENCE

of TO

Phenocoll ITS

EMPLOY-

Malaria.?By David Cerna, pli.D.? Therapeutic Guzctte, December 15, MENT

in

?Dr. Cerna

points

out

that

there

are

M.D.,

1893. certain

INDIAN MEDICAL GAZETTE.

150

vesicle of cow-pox was produced. From these vesicles children were vaccinated and vaccinia of the most perfect type ensued; the areola not commencing until the beginning of the ninth day, with marked febrile reaction; the crusts fell off on the twenty-fifth day. A second series of cultures started from another specimen of vaccine lymph presented the same features. After three days in the thermostat numerous small white colonies are seen on the surface of the medium and a cloud appears in the lower part of the condensation water. Each colony occupies a little depression which it has formed by liquifying the medium about it. Later, the liquified blood serum flows down from the colonies carrying the growth with it. When a culture is seven days old another tube i3 iuocu lated aud the old tube removed from the thermostat. The bacterium varies in form according to the various conditions of its nutritive environment and the consequent rate of its development. The most constant and prevalent form is a short, fine bacillus with rounded or nearly square ends. When the nutrient medium is fresh the bacterium divides more rapidly and forms very short bacilli and often even a pure micrococcus form. Cover-glass specimens of the growth stain well after a few seconds' exposure to Ziehl's carbolic acid fuchsin solution.

perfect

Clemen's Solution.?Some little time ago I drew attention to the use of Clemen's solution Messrs. in the treatment of diabetes mellitus. Smith, Stanistreet and Company have kindly furnished me with directions for its preparation :? 60 grains. Carbonate of Potash ...

...

Arsenious Acid Distilled Water

Boil until

a

???

...

...

...

60 ? 10 ounces.

; when cold add? 11 q. b. to 12 ounces. 120 grains.

solution is formed

Distilled "Water Bromine ...

...

...

Set aside until it decolorises. The dose of this " Liquor Arsenici Bromatus" is, as before stated, 1 to 3 to 5 drops once or twice a day. Surg.-Capt. J. H. Tull-Walsh.

[April

1894.

Medicine: Therapeutic Uses of Phenocoll-Antidote to Hydrocyanic Acid, &c.

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