PROSTAGLANDINS
MEASUREMENT OF PROSTAGLAEDIN F2uLEVELS IN CEFEBROSPINAL FLUID OF FEBRILE AED AFEBRILE PATIENTS WITH ADVANCED CANCER
I. S. Landaw and C. W. Young* Department of Medicine Memorial Sloan-Kettering Cancer Center New York, N. Y. 10021
ABSTRACT
Prostaglandin F2e levels were measured by radioiuanunoassay in 95 samples of unextracted human cerebrospinal fluid obtained from 73 patients with advanced cancer. Concentrations of PGE were too low to be reliably determined by this method using the commercially available kits. Forty-six of the samples assayed contained 900
Figure 5. Relationship between PGF2~ levels and protein concentration in cerebrospinal fluid.
25
:
I,.: , •
330 330
Z
O
PROSTAGLANDINS
References
1.
and S. Wendlandt. A possible role A.S. prostaglandln El as a modulator for temperature tlo,. o,, the central ner~ious system of the cat, Fhyslol. x:76, 1970.
2.
A.S. and S. Wendlandt. Effects on body temperaMilton, ture of prostaglandlns of the A, I: and F series on ln,ectuxn into the third ventricle of unanaesthetlzed .,. Physlol. =:121, 1971. cats and rabbits,
3.
w. and P.N. ~asena. FEI.CT produced I" rabbits reldberg, and cats by prostaglandln El In,ected into the cerebral J. Phys'c'l. x:23, 1971. w2ntr1c1es.
4.
MLlton, A.S. and S. iuendlandt. The effects of 4-acetam~dophenol (paracetamol) on the temperature response of the CO,,SCIOUS rat to the lntracerebral rn,ectlon of and pyrogen, J. Physrol. prostaglandln El, adrenalin E:33P, 1971.
5
.
6.
Milton,
for regulaJ.
of prostaglandln synthesis as a vane. J.R. Inhlbltlon mcchan~sm of actlo" for asprrln-lxke drugs, Nature ,New "101.) =:231, 1971. P.J. and J.R. Vane. Inhlbltlon of prustaqlandln Flower, synthctase 1" brain explains the anti-pyretlc actl\lt> of paracetamol il-acetamldophenol), 1972.
Nature2_zo:JlO,
I,, Advanced I" Neurochemistry, Editors, Plenum M.H. Apr~son, Nei York ,975, p. 21.
I'ul. 1 (B.W. Publlshlng
7.
Wolfe, L.S., Aqranoff and COlpOrat10".
8.
,'eldberg, W. and h.F. glandln-{Ike actlvlty 3:41. 1973.
9.
rcldberg, I\., Gupta, K.P., Milton, A.S. and S. Wendlandt. Effect of pyrogen and antlpyretlcs on prostaglandl" actlvlty 1" clsternal c.s.f. of unanaesthetlzed cats, J. Fhyslol. =:279, 1971.
10.
ProstaHarirey, C.A., Mlltc'n. A.S. and ".W. Stranghan. glandx C levels I,, cerebrosp~nal fluid of rabbits nnd the effects of bacterial pyrogen and antlpjretlc drugs, J. Fhyslol. 2_1e:?7. 1975.
11.
and thr Cocronl, r., Prvstaglandrns Arch. Inter". MCil. =:11", system,
12.
Hendricks. C.,,., iIre""er, ii‘.,., iI-l,i.,dh,ii., nrutanrk, V. and .,.I. Flshburne, Jr. i‘fflcncy and tc'lrrancc uf I"tra"enc'us prostn4landnE I‘, an-l I:', all. J. (Ibstct. 2,~"CCUl. g:v2, 1971.
Gupta. ~yrogen in cerebrospnal
fever and prostafluid, J. Phys~ol.
crntrol IUii.
ncr""us
13.
14.
1 7,.
I(..
AUGUST 1977 VOL. 14 NO. 2
353
MEASUREMENT OF PROSTAGLAEDIN F2uLEVELS IN CEFEBROSPINAL FLUID OF FEBRILE AED AFEBRILE PATIENTS WITH ADVANCED CANCER
I. S. Landaw and C. W. Young* Department of Medicine Memorial Sloan-Kettering Cancer Center New York, N. Y. 10021
ABSTRACT
Prostaglandin F2e levels were measured by radioiuanunoassay in 95 samples of unextracted human cerebrospinal fluid obtained from 73 patients with advanced cancer. Concentrations of PGE were too low to be reliably determined by this method using the commercially available kits. Forty-six of the samples assayed contained 900
Figure 5. Relationship between PGF2~ levels and protein concentration in cerebrospinal fluid.
25
:
I,.: , •
330 330
Z
O
PROSTAGLANDINS
References
1.
and S. Wendlandt. A possible role A.S. prostaglandln El as a modulator for temperature tlo,. o,, the central ner~ious system of the cat, Fhyslol. x:76, 1970.
2.
A.S. and S. Wendlandt. Effects on body temperaMilton, ture of prostaglandlns of the A, I: and F series on ln,ectuxn into the third ventricle of unanaesthetlzed .,. Physlol. =:121, 1971. cats and rabbits,
3.
w. and P.N. ~asena. FEI.CT produced I" rabbits reldberg, and cats by prostaglandln El In,ected into the cerebral J. Phys'c'l. x:23, 1971. w2ntr1c1es.
4.
MLlton, A.S. and S. iuendlandt. The effects of 4-acetam~dophenol (paracetamol) on the temperature response of the CO,,SCIOUS rat to the lntracerebral rn,ectlon of and pyrogen, J. Physrol. prostaglandln El, adrenalin E:33P, 1971.
5
.
6.
Milton,
for regulaJ.
of prostaglandln synthesis as a vane. J.R. Inhlbltlon mcchan~sm of actlo" for asprrln-lxke drugs, Nature ,New "101.) =:231, 1971. P.J. and J.R. Vane. Inhlbltlon of prustaqlandln Flower, synthctase 1" brain explains the anti-pyretlc actl\lt> of paracetamol il-acetamldophenol), 1972.
Nature2_zo:JlO,
I,, Advanced I" Neurochemistry, Editors, Plenum M.H. Apr~son, Nei York ,975, p. 21.
I'ul. 1 (B.W. Publlshlng
7.
Wolfe, L.S., Aqranoff and COlpOrat10".
8.
,'eldberg, W. and h.F. glandln-{Ike actlvlty 3:41. 1973.
9.
rcldberg, I\., Gupta, K.P., Milton, A.S. and S. Wendlandt. Effect of pyrogen and antlpyretlcs on prostaglandl" actlvlty 1" clsternal c.s.f. of unanaesthetlzed cats, J. Fhyslol. =:279, 1971.
10.
ProstaHarirey, C.A., Mlltc'n. A.S. and ".W. Stranghan. glandx C levels I,, cerebrosp~nal fluid of rabbits nnd the effects of bacterial pyrogen and antlpjretlc drugs, J. Fhyslol. 2_1e:?7. 1975.
11.
and thr Cocronl, r., Prvstaglandrns Arch. Inter". MCil. =:11", system,
12.
Hendricks. C.,,., iIre""er, ii‘.,., iI-l,i.,dh,ii., nrutanrk, V. and .,.I. Flshburne, Jr. i‘fflcncy and tc'lrrancc uf I"tra"enc'us prostn4landnE I‘, an-l I:', all. J. (Ibstct. 2,~"CCUl. g:v2, 1971.
Gupta. ~yrogen in cerebrospnal
fever and prostafluid, J. Phys~ol.
crntrol IUii.
ncr""us
13.
14.
1 7,.
I(..
AUGUST 1977 VOL. 14 NO. 2
353
