20 Endocrine Care

Maternal Thyroid Function and Autoimmunity in 3 Trimesters of Pregnancy and their Offspring’s Thyroid Function

Authors

P. Sarkhail1, L. Mehran1, S. Askari1, Z. Tahmasebinejad1, M. Tohidi2, F. Azizi1

Affiliations

1

Key words ▶ thyroid hormones ● ▶ antibodies ● ▶ pregnancy ● ▶ cord blood ● ▶ neonates ● ▶ infants ●

received 08.11.2014 accepted 23.06.2015 Bibliography DOI http://dx.doi.org/ 10.1055/s-0035-1555878 Published online: November 13, 2015 Horm Metab Res 2016; 48: 20–26 © Georg Thieme Verlag KG Stuttgart · New York ISSN 0018-5043 Correspondence F. Azizi, MD Professor of Internal Medicine & Endocrinology Endocrine Research Center Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences P. O. Box: 19395-4763 Tehran I. R. Iran Tel.:  + 98/21/22409 309 Fax:  + 98/21/22402 463 [email protected]

Abstract

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This study was performed to evaluate maternal thyroid dysfunction and autoimmunity during pregnancy and its correlation with thyroid function of offspring. In this cohort study, Serum TT4, TT3, T3U, TSH, TPOAb, and TgAb were measured. Serum samples of 120 pregnant women were collected during 3 trimesters as well as in 57 cord bloods, 69 neonates, 34, 37, and 36 infants aged 2, 4, and 6 months. Repeated measure and Pearson correlation test were used to compare ­thyroid hormone values and to assess the correlations, respectively. Main outcomes were correlations between thyroid hormones and antibodies in mothers and offspring. An increasing trend for TT3 (p for trend