Accepted Manuscript Maternal marijuana use and neonatal morbidity Shayna N. Conner, MD, MSCI, Ebony B. Carter, MD, MPH, Methodius G. Tuuli, MD, MPH, George A. Macones, MD, MSCE, Alison G. Cahill, MD, MSCI PII:

S0002-9378(15)00527-X

DOI:

10.1016/j.ajog.2015.05.050

Reference:

YMOB 10433

To appear in:

American Journal of Obstetrics and Gynecology

Received Date: 6 March 2015 Revised Date:

22 April 2015

Accepted Date: 26 May 2015

Please cite this article as: Conner SN, Carter EB, Tuuli MG, Macones GA, Cahill AG, Maternal marijuana use and neonatal morbidity, American Journal of Obstetrics and Gynecology (2015), doi: 10.1016/j.ajog.2015.05.050. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

ACCEPTED MANUSCRIPT Conner SN

Maternal marijuana use and neonatal morbidity

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Shayna N. CONNER, MD, MSCI1

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Ebony B. CARTER, MD, MPH1

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Methodius G. TUULI, MD, MPH1

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George A. MACONES, MD, MSCE1

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Alison G. CAHILL, MD, MSCI1

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The authors report no conflicts of interest

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Presentation: This abstract was a poster presentation at the annual meeting of the Society of

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Department of Obstetrics and Gynecology, Washington University in St. Louis

Maternal Fetal Medicine, February 2-7, 2015, San Diego, California.

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Funding: Dr. Cahill was a Robert Wood Johnson Foundation Physician Faculty Scholar, which

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partially supported this work

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Reprints will not be available

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Corresponding Author:

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Shayna N. Conner, M.D.

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Department of Obstetrics and Gynecology, Washington University School of Medicine

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4911 Barnes Jewish Hospital Plaza, Campus Box 8064, St. Louis, MO 63110

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Phone 314 362 7300; Fax 314 747 1720

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Email: [email protected]

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Word count: Abstract=240, Main text=2162

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Condensation: Marijuana use is common in pregnancy, but is not an independent risk factor for

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poor neonatal outcomes in term pregnancies.

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Short version of title: Marijuana use and neonatal morbidity

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Marijuana use and neonatal morbidity 2

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Abstract:

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OBJECTIVE: Marijuana use is becoming increasingly common in the obstetric population,

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however it is unknown whether it is associated with poor neonatal outcomes. We sought to

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determine the prevalence and risk factors for marijuana use in pregnancy, and to evaluate

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whether marijuana use is independently associated with poor neonatal outcomes.

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STUDY DESIGN: This was a retrospective cohort study of all consecutive, non-anomalous,

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term deliveries at one institution over a 4 year study period. Women with marijuana use during

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pregnancy, either by self-report or positive urine drug screen, were compared with women who

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did not use marijuana. The primary outcome was a composite neonatal morbidity including:

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birth-weight less than 2500g, NICU admission, 5 minute APGAR score less than 7, and

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umbilical artery pH